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Method for preparing polymeric micron/nanometer spherical particle

A technology of micro-nano spheres and polymers, which is applied in the field of preparing micro-nano spheres, can solve the problems of wide distribution of micellar particle size and complicated process, and achieves the effects of low cost, simple steps and good prospects for large-scale production.

Active Publication Date: 2012-08-22
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to overcome the defects of complex process and wide micelle particle size distribution in the prior art, and provide a method for preparing polymer micro-nano spheres

Method used

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  • Method for preparing polymeric micron/nanometer spherical particle
  • Method for preparing polymeric micron/nanometer spherical particle
  • Method for preparing polymeric micron/nanometer spherical particle

Examples

Experimental program
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Effect test

Embodiment 1

[0027] (1) get the block copolymer of 5g polystyrene and polybutadiene (polybutadiene volume ratio is 30%) and dissolve in 45g toluene, obtain the solution that polymer weight ratio is 10%;

[0028] (2) Add 1 mol of formic acid and hydrogen peroxide in a three-necked flask, and react for half an hour at 70° C. to make peroxyformic acid; Add 2mol formic acid to continue the reaction for 3h after the end of the reaction;

[0029] (3) Add methanol to the obtained hydroxylated product for precipitation, then filter, and repeat the operation 3 times. Take out the final polymer and dry it in a vacuum oven at 70°C for 12 hours;

[0030] (4) Take 0.05 g of the dried hydroxylated product in a hydrothermal reaction kettle, and add 9.95 g of acetic acid, so that the polymer mass ratio is 0.5%;

[0031] (5) The obtained sample was heat-treated at 150° C. for 15 hours to obtain polymer micro-nano spheres with narrow particle size distribution. The scanning electron micrographs of the ob...

Embodiment 2

[0033] (1) get the block copolymer of 5g polystyrene and polybutadiene (polybutadiene volume ratio is 30%) and dissolve in 45g toluene, obtain the solution that polymer weight ratio is 10%;

[0034] (2) Add 1 mol of formic acid and hydrogen peroxide in a three-necked flask, and react for half an hour at 70° C. to make peroxyformic acid; Add 2mol formic acid to continue the reaction for 3h after the end of the reaction;

[0035] (3) Add methanol to the obtained hydroxylated product for precipitation, then filter, and repeat the operation 3 times. Take out the final polymer and dry it in a vacuum oven at 70°C for 12 hours;

[0036] (4) Take 0.05 g of the dried hydroxylated product in a hydrothermal reaction kettle, and add 9.95 g of acetic acid, so that the polymer mass ratio is 0.5%;

[0037] (5) Heat the obtained sample at 100° C. for 15 hours to obtain polymer micro-nano spheres with narrow particle size distribution. The scanning electron micrographs of the obtained spher...

Embodiment 3

[0039] (1) get 5g polystyrene-butadiene-styrene triblock copolymer (polybutadiene volume is 35%) and dissolve in 25g tetrahydrofuran, obtain the solution that polymer weight ratio is 16.7%;

[0040] (2) Add 10g potassium permanganate and 20g polymer solution to react for 4h in a three-necked flask;

[0041] (3) Add ethanol to the obtained hydroxylated product for precipitation, then filter, and repeat the operation 3 times. Remove the final polymer and dry it in a vacuum oven at 60°C for 15 hours;

[0042] (4) Take 0.1 g of the dried hydroxylated product in a hydrothermal reaction kettle, and add 29.9 g of formic acid, so that the weight ratio of the polymer is 0.33%;

[0043] (5) Heat the obtained sample at 100° C. for 4 hours to obtain polymer micro-nano spheres with narrow particle size distribution.

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Abstract

The invention discloses a method for preparing a polymeric micron / nanometer spherical particle. The micron / nanometer spherical particle prepared by the method is narrow in particle size distribution, and the obtained polymeric micron / nanometer spherical particle can be used in the aspects of a drug carrier, a permeable blood-brain barrier, gene inheritance, a developer carrier and the like. The method for preparing the polymeric micrometer / nanometer spherical particle, which is provided by the invention, comprises the following steps of: 1), dissolving a segmented copolymer into an organic solvent to prepare a segmented copolymer solution; 2), carrying out hydroxylation processing on the prepared segmented copolymer solution; 3), carrying out precipitation processing on an obtained hydroxylated product through a precipitant; 4), carrying out vacuum drying processing on the hydroxylated product obtained through precipitation; and 5), adding the dried hydroxylated product into a polar solvent to be subjected to micellization, so as to obtain the polymeric micrometer / nanometer spherical particle which is narrow in particle size distribution.

Description

technical field [0001] The invention relates to a method for preparing micro-nano spheres, in particular to a method for preparing polymer micro-nano spheres. Background technique [0002] Polymer micro-nanoparticles are a kind of solid drug-loaded colloidal particles with natural or synthetic polymer materials as the carrier, and the general particle size is 10-1000nm. Nanoparticles are the general term for nanospheres and nanocapsules. Compared with microspheres, nanoparticles have better physical stability and are convenient for heat sterilization and storage; because they belong to a colloidal system, they are easier to administer clinically than suspension microsphere preparations; due to their small particle size and large surface energy It is beneficial to stay in the mucous membrane, cornea, etc., which is beneficial to the absorption of the drug and improves the bioavailability of the drug; it can be made into a skeleton-type sustained-release preparation; after be...

Claims

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Application Information

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IPC IPC(8): C08J3/12C08J3/14C08L53/00C08L53/02C08F297/04C08F8/06
Inventor 汪勇廖行知
Owner NANJING UNIV OF TECH
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