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Cyclodextrin derivative transdermal composite film agent and preparation method thereof

A technology of composite film agent and derivatives, which is applied in the direction of non-active ingredients of polymer compounds and sheet-like delivery, can solve problems such as the limitation of solubility and sustained release effects, and achieve good research and development application prospects, wide applicability, good The effect of translucency

Inactive Publication Date: 2013-08-07
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of its non-toxic, harmless to human body, good biocompatibility, biodegradable and other advantages, it has been widely used in the preparation of slow-release film carrier, but due to the solubility of chitosan, the slow-release effect of the drug is limited to a certain extent.

Method used

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  • Cyclodextrin derivative transdermal composite film agent and preparation method thereof
  • Cyclodextrin derivative transdermal composite film agent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] The transdermal composite film of cyclodextrin derivatives in this embodiment is prepared by the following steps: add 1.0 g of carboxymethyl chitosan to 50 ml of deionized water, then add 2 ml of glycerin, stir and dissolve at a speed of 3000 rpm to make carboxymethyl chitosan base chitosan solution; add 2.5g PVA05-88 into 50ml deionized water, then add 2ml azone, fully stir and dissolve to make PVA05-88 solution, add hydroxypropyl-β-cyclodextrin to PVA05-88 solution 2.5g, stir and dissolve to obtain PVA05-88-hydroxypropyl-β-cyclodextrin solution; add 2g of the active substance ranitidine hydrochloride to the PVA05-88-hydroxypropyl-β-cyclodextrin solution, stir to dissolve , to prepare PVA05-88-hydroxypropyl-β-cyclodextrin-loaded active substance solution; slowly add carboxymethyl chitosan solution to PVA05-88-hydroxypropyl-β-cyclodextrin-loaded active substance solution , stir and mix well, let stand to exhaust, wait until the air bubbles are exhausted, planar cast coa...

Embodiment 2

[0027] The transdermal composite film of cyclodextrin derivatives in this embodiment is prepared by the following steps: add 5.0g of chitosan quaternary ammonium salt to 50ml of deionized water, then add 5ml of propylene glycol, stir and dissolve at a speed of 3000rpm, and make chitosan Sugar quaternary ammonium salt solution; add 0.5g of PVA17-88 to 50ml of deionized water, then add 1.5ml of azone, fully stir and dissolve to make a PVA17-88 solution, and add carboxymethyl-β-cyclodextrose to the PVA17-88 solution 0.75g of essence, stir and dissolve to obtain PVA17-88-carboxymethyl-β-cyclodextrin solution; add 0.5g of active substance mercaptopurine to PVA17-88-carboxymethyl-β-cyclodextrin solution, and disperse evenly. Prepare the PVA17-88-carboxymethyl-β-cyclodextrin loaded active substance solution; slowly add the chitosan quaternary ammonium salt solution into the PVA17-88-carboxymethyl-β-cyclodextrin loaded active substance solution, Stir and mix evenly, let stand to exhau...

Embodiment 3

[0029] The transdermal composite film of cyclodextrin derivatives in this embodiment is obtained through the following steps: add 0.5g carboxypropyl chitosan to 50ml deionized water, then add 1ml sorbitol, stir and dissolve at a speed of 3000rpm, and make carboxypropyl chitosan Propyl chitosan solution; add 2.5gPVA17-88 and 2.5gPVA05-88 into 50ml deionized water, then add 4.45g menthol, stir and dissolve fully to make a polyvinyl alcohol solution, add hydroxypropyl chitosan to the polyvinyl alcohol solution 2.5g of polyvinyl-α-cyclodextrin, stirred and dissolved to obtain polyvinyl alcohol-hydroxypropyl-α-cyclodextrin solution; add 1g of active substance insulin to the solution of polyvinyl alcohol-hydroxypropyl-α-cyclodextrin , stirring and dissolving to prepare the polyvinyl alcohol-hydroxypropyl-α-cyclodextrin loaded active substance solution; slowly add the carboxypropyl chitosan solution to the polyvinyl alcohol-hydroxypropyl-α-cyclodextrin loaded active substance In the ...

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Abstract

The invention relates to the technical field of high polymer materials and particularly discloses a cyclodextrin derivative transdermal composite film agent and a preparation method thereof. The preparation method for the cyclodextrin derivative transdermal composite film agent comprises the following steps of: adding a cyclodextrin derivative into a polyvinyl alcohol solution and stirring uniformly to obtain a polyvinyl alcohol-cyclodextrin derivative solution; adding an active substance into the polyvinyl alcohol-cyclodextrin derivative solution to obtain a polyvinyl alcohol-cyclodextrin derivative-loaded active substance solution; and adding a chitosan hydrophilic derivative solution into the polyvinyl alcohol-cyclodextrin derivative-loaded active substance solution, coating or paving in a curtain coating mode and drying to obtain the cyclodextrin derivative transdermal composite film agent, or coating the chitosan hydrophilic derivative solution in a curtain coating mode to form afilm, airing, coating the polyvinyl alcohol-cyclodextrin derivative-loaded active substance solution on the film in a curtain coating mode to form a film and airing to obtain the cyclodextrin derivative transdermal composite film agent.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a cyclodextrin derivative transdermal composite membrane agent and a preparation method thereof. Background technique [0002] Transdermal drug delivery system or transdermal absorption preparation (TTS for short) refers to a type of preparation that is applied through the skin, and the drug is absorbed through the skin into the blood circulation of the whole body and reaches an effective blood concentration to achieve disease treatment or prevention. Since the first TTS scopolamine patch was launched in the United States in 1981, there have been a variety of transdermal preparations, such as nitroglycerin, estradiol, fentanyl, clonidine, testosterone, nitrendipine, timolol, etc. , TTS clinical application is generally welcomed. Chinese medical scientists have long been aware of transdermal drug delivery, and have collected a large number of plaster prescriptions for l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/40
Inventor 周惠云张兆青任云利陈雅维周冬菊李瑞敏
Owner HENAN UNIV OF SCI & TECH
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