Plasma coupling structure microsphere for surface-enhanced Raman scattering (SERS) and manufacturing method thereof

A surface-enhanced Raman, plasma coupling technology, applied in Raman scattering, material excitation analysis, etc., can solve problems such as affecting application, no biocompatibility of gold particles, and insufficient silver, achieving low equipment energy consumption and process Novel, special structure and controllable effect
CN102699321AInactive Publication Date: 2012-10-03EAST CHINA UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
EAST CHINA UNIV OF SCI & TECH
Publication Date
2012-10-03
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to a plasma coupling structure microsphere for surface-enhanced Raman scattering (SERS). By the plasma coupling structure microsphere, a magnetic microsphere serves as a kernel, and a metal cladding I, a nonmetallic isolating layer and a metal cladding II are formed outside the kernel one by one, wherein the metal cladding I or the metal cladding II has the thickness of 0 to 50nm; the nonmetallic isolating layer has the thickness of 0 to 100nm; and the plasma coupling structure microsphere has the particle size of 300 to 1,000nm and the specific saturation magnetization of 10 to 50emu / g. The plasma coupling structure microsphere is simple in manufacturing method and controllable in product structure, the obtained microsphere can be suitable for biological separation and detection, and when the microsphere is used for detecting a Raman-enhanced effect, the detection rate can reach 10<-9> mol / L; and moreover, the plasma coupling structure microsphere is applied to the fields of photochemical catalysis, disease detection, food safety and the like, and the application prospect integrating separation and SERS detection on biological medical molecules and the like can be realized.
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Description

technical field

[0001] The invention relates to a material in the technical field of separation and detection of biomedicine and fine chemicals and a preparation method thereof, in particular to a magnetic microsphere with an Ag-Au long-range plasma coupling structure for surface-enhanced Raman and a preparation method thereof. Background technique

[0002] Surface-enhanced Raman spectroscopy (SERS) overcomes the shortcomings of low sensitivity of ordinary Raman techniques, can improve Raman signals, and can realize single-molecule detection, and is widely used in chemical and biomedical detection. At present, there are many methods to prepare substrates with SERS effect. For example, the most common rough noble metal surface by electrochemical deposition, nanoscale metal film formed by sputtering, prepared metal sol, etc. Among the above methods, the preparation method of metal sol is the simplest and has a high enhancement effect, so it is widely used in SERS detection. ...

Claims

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