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Plasma coupling structure microsphere for surface-enhanced Raman scattering (SERS) and manufacturing method thereof

A surface-enhanced Raman and plasma coupling technology, used in Raman scattering, material excitation analysis, etc., can solve the problems of insufficient silver, influence application, no biocompatibility of gold particles, and achieve special controllable structure and equipment. The effect of low energy consumption and novel process

Inactive Publication Date: 2014-07-23
EAST CHINA UNIV OF SCI & TECH
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the spectral region of a single gold structural material is limited from 600 nm to far infrared, which is not wide enough compared to silver (450 nm), and the single silver particles do not have the excellent biocompatibility of gold particles. Impact on the application of Raman detection in biomedicine

Method used

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  • Plasma coupling structure microsphere for surface-enhanced Raman scattering (SERS) and manufacturing method thereof
  • Plasma coupling structure microsphere for surface-enhanced Raman scattering (SERS) and manufacturing method thereof
  • Plasma coupling structure microsphere for surface-enhanced Raman scattering (SERS) and manufacturing method thereof

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Embodiment

[0025] A method for preparing surface-enhanced Raman plasmon-coupled structural microspheres, comprising the following steps:

[0026] (a) Solvent hydrothermal method to prepare Fe 3 o 4 Magnetic Microspheres

[0027] Sequentially weigh 0.650 g of ferric chloride, 1.000 g of sodium acetate in water, and 0.250 g of trisodium citrate, and take 20 mL

[0028] Ethylene glycol, stirred until the solution is uniform. The solution was transferred to a 50 mL hydrothermal kettle and heated at 200 °C for 10 h. Naturally cooled to room temperature, washed with ethanol and water to obtain Fe 3 o 4 The average size of the magnetic microspheres is 330 nm.

[0029] (b) Coating of Ag layer

[0030] Weigh 0.200g Fe 3 o 4 , 0.100g AgNO 3 and 2.500g PVP-K30, measure 24 mL ethylene glycol,

[0031] The reaction was carried out at 100° C. for 12 hours. Wash with ethanol and deionized water, and dry the product to obtain Fe 3 o 4 Ag composite microspheres. The thickness of the Ag lay...

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Abstract

The invention relates to a plasma coupling structure microsphere for surface-enhanced Raman. The plasma coupling structure microsphere uses a magnetic microsphere as the inner core, and forms a metal coating layer I, a non-metallic isolation layer and a metal coating layer outside the inner core layer by layer. Coating layer II; the thickness of the metal coating layer I or metal coating layer II is 0-50 nm, and the thickness of the non-metallic isolation layer is 0-100 nm; the particle size of the plasma-coupling structure microsphere is 300 nm ~1000nm, the specific saturation magnetization is 10~50emu / g. The preparation method of the plasma-coupled structure microsphere is simple, and the product structure is controllable. The obtained microsphere can be applied to bioseparation detection, and the detection can reach 10-9mol / L when used to detect Raman enhancement effect; it is also suitable for photochemical catalysis , disease detection and food safety and other fields, and at the same time, it can realize the application prospect of the integration of separation and SERS detection of biomedical molecules.

Description

technical field [0001] The invention relates to a material in the technical field of separation and detection of biomedicine and fine chemicals and a preparation method thereof, in particular to a magnetic microsphere with an Ag-Au long-range plasma coupling structure for surface-enhanced Raman and a preparation method thereof. Background technique [0002] Surface-enhanced Raman spectroscopy (SERS) overcomes the shortcomings of low sensitivity of ordinary Raman techniques, can improve Raman signals, and can realize single-molecule detection, and is widely used in chemical and biomedical detection. At present, there are many methods to prepare substrates with SERS effect. For example, the most common rough noble metal surface by electrochemical deposition, nanoscale metal film formed by sputtering, prepared metal sol, etc. Among the above methods, the preparation method of metal sol is the simplest and has a high enhancement effect, so it is widely used in SERS detection. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F1/02B22F1/00G01N21/65
Inventor 朱以华沈建华杨晓玲范开才钟华
Owner EAST CHINA UNIV OF SCI & TECH
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