Low temperature synthesis method for monodisperse polymer microsphere

A synthesis method and polymer technology, applied in the chemical industry, can solve problems such as denaturation failure
CN102718894AActive Publication Date: 2012-10-10HEBEI ZHISHENG GREEN TECH
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
HEBEI ZHISHENG GREEN TECH
Publication Date
2012-10-10

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Abstract

The invention provides a low temperature synthesis method for a monodisperse polymer microsphere. The method includes the steps of 1) dissolving a free radical polymerization monomer, a stable dispersant, a reversible addition-fragmentation chain transfer agent (RAFT) and a photoinitiator in a reaction medium to obtain a mixture; and 2) feeding nitrogen to deoxidize and subjecting the mixture to a light reaction at a temperature between 0 DEG C to 90 DEG C in a stirring state to obtain the monodisperse polymer microsphere. According to the method, on a basis of light dispersion polymerization, a controllable / 'living' radical polymerization mechanism is introduced, and a control reagent of a free radical polymerization is added, so that a photopolymerization which is overquick previously is slowed down, a highly monodisperse polymer microsphere is obtained, and the problem that denaturation and effectiveness losing of heat labile components such as polypeptide and protein caused by a thermal-initiation polymerization under the long time heating in prior art are prone to occur is solved.
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Description

technical field

[0001] The invention relates to the technical field of chemical industry, in particular to a low-temperature synthesis method of monodisperse polymer microspheres. Background technique

[0002] Polymer functional microspheres are widely used in biomedicine, electronic information, coating ink, chromatographic separation and other fields. In recent years, with the rapid development of the field of biomedicine, higher requirements have been put forward for the preparation technology of polymer microspheres.

[0003] Polymer microspheres can be prepared by methods such as emulsion polymerization, miniemulsion polymerization, microemulsion polymerization, dispersion polymerization, precipitation polymerization, and suspension polymerization. Among them, the dispersion polymerization method is a commonly used microsphere preparation method. Compared with other methods, its main advantage is that microspheres from nanometer to micrometer can be obtained, and the o...

Claims

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