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Preparation method of water-soluble N-acetyl-L-cysteic acid-modified CdTe quantum dot

A cysteine ​​and water-soluble technology, applied in chemical instruments and methods, luminescent materials, etc., can solve the problems of limiting the application of CdTe quantum dots, poor biocompatibility, and instability of small molecules, and achieve low cost and biophase Good capacity, simple and convenient operation

Inactive Publication Date: 2012-10-10
GUANGXI TEACHERS EDUCATION UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Such small molecules are unstable, volatile, odorous, highly toxic, carcinogenic, and poor in biocompatibility, which greatly limits the application of CdTe quantum dots in the fields of biochemical analysis and biomedicine

Method used

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  • Preparation method of water-soluble N-acetyl-L-cysteic acid-modified CdTe quantum dot

Examples

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Embodiment 1

[0022] A preparation method of water-soluble N-acetyl-L-cysteine ​​modified CdTe quantum dots, the steps are as follows:

[0023] (1) Preparation of sodium telluride hydride NaHTe solution

[0024] 0.2mmol Te powder and 0.4mmol NaBH 4 Put it into a two-necked flask, add 5mL of distilled water, protect it with nitrogen, and react at 70°C for 1h to obtain a sodium telluride hydride NaHTe solution for later use;

[0025] (2) Preparation of CdTe quantum dots

[0026] 0.02mmol CdCl 2 Dissolve 0.02mmol N-acetyl-L-cysteine ​​in 40mL distilled water, adjust the pH value to 8.0 with 1mol / L NaOH solution, add 50μL sodium telluride hydride NaHTe solution, protect with nitrogen, and heat to reflux at 70°C for 5min , 40 mL of water-soluble CdTe quantum dot solution with adjustable fluorescence emission wavelength and high fluorescence quantum yield can be obtained.

Embodiment 2

[0028] A preparation method of water-soluble N-acetyl-L-cysteine ​​modified CdTe quantum dots, the steps are as follows:

[0029] 1. Preparation of potassium hydride telluride KHTe solution

[0030] 0.4mmol Te powder and 2.0mmol KBH 4 Put it into a two-necked flask, add 4mL of distilled water, protect it with nitrogen, and react at 90°C for 12h to obtain potassium telluride hydride KHTe solution for later use;

[0031] 2. Preparation of CdTe quantum dots

[0032] 0.4mmol CdBr 2 Dissolve 0.8mmol N-acetyl-L-cysteine ​​in 20mL distilled water, adjust the pH value to 10.0 with 1mol / L NaOH solution, add 2mL potassium telluride hydride KHTe solution, protect with nitrogen, and heat at reflux at 90°C for 35min , 20 mL of water-soluble CdTe quantum dot solution a with adjustable fluorescence emission wavelength and high fluorescence quantum yield can be obtained.

Embodiment 3

[0034] A preparation method of water-soluble N-acetyl-L-cysteine ​​modified CdTe quantum dots, the steps are as follows:

[0035] 1. The preparation of potassium hydride telluride KHTe solution is the same as step 1 of embodiment 2. The preparation of potassium hydride telluride KHTe solution.

[0036] 2. Preparation of CdTe quantum dots The rest of the conditions are the same as step 2. Preparation of CdTe quantum dots in Example 2, only the reaction time is changed to 42min, then 20mL of quantum dot solution b is obtained.

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Abstract

The invention discloses a preparation method of a water-soluble N-acetyl-L-cysteic acid-modified CdTe quantum dot. The preparation method comprises the following operating step of: under the protection of nitrogen gas, injecting a prepared sodium hydrogen telluride NaHTe or potassium hydrogen telluride KHTe solution into a prepared mixed solution of a cadmium salt and water-soluble N-acetyl-L-cysteic acid to obtain a water-soluble CdTe quantum dot with an adjustable fluorescence emission wavelength and high fluorescence quantum yield. The invention has the advantages: the method has the advantages of readily-available raw materials, low cost, easiness and safety for operating, environment friendliness and the like; and the prepared water-soluble CdTe quantum dot has the advantages of high water solubility, adjustable fluorescence emission wavelength, high fluorescence quantum yield, high biocompatibility and the like, and can be taken as a novel fluorescence nano-probe for wide application to the fields of biochemical analysis and biomedicine.

Description

technical field [0001] The invention belongs to the technical field of biochemical analysis and detection technology and nanometer material preparation, and in particular relates to a preparation method of water-soluble N-acetyl-L-cysteine ​​modified CdTe quantum dots. Background technique [0002] With the in-depth research and wide application of quantum dots in the fields of chemistry, biology, medicine and medical diagnosis, the synthesis of high-quality, multifunctional fluorescent quantum dots has attracted great attention. At present, different quantum dots such as CdS, CdSe, and CdTe have been prepared by organic phase synthesis, and the fluorescence quantum yield is as high as 40-85%. However, the quantum dots obtained by the organic phase synthesis method can only be dispersed in non-polar or weakly polar organic solvents and cannot be dispersed in aqueous solutions, which has poor biocompatibility, which greatly limits the application of such quantum dots in bioch...

Claims

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Application Information

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IPC IPC(8): C09K11/88
Inventor 肖琦黄珊苏炜
Owner GUANGXI TEACHERS EDUCATION UNIV
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