Sea urchin-like hydroxyapatite microparticles, preparation method and application thereof

A technology of hydroxyapatite and sea urchin, applied in the field of hydroxyapatite particles and its preparation

Inactive Publication Date: 2012-10-17
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] It is not difficult to find that most of the current studies on the morphology of hydroxyapatite focus on needle-like, spherical and porous shapes, and there are few reports on other special shapes such as sea urchin-like.

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  • Sea urchin-like hydroxyapatite microparticles, preparation method and application thereof
  • Sea urchin-like hydroxyapatite microparticles, preparation method and application thereof

Examples

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Embodiment 1

[0024] Dissolve 2.8170g calcium nitrate tetrahydrate and 1.4286g urea in 12.5ml deionized water; dissolve 0.9430g diammonium hydrogen phosphate in 10ml deionized water; dissolve 0.7143g sorbitol in 10ml deionized water; dissolve diammonium hydrogen phosphate The solution and the sorbitol solution were added dropwise into the mixed solution of calcium nitrate tetrahydrate and urea while stirring respectively, and after stirring for 30 minutes, moved into a 50ml Teflon-lined hydrothermal kettle, and reacted at 110°C for 20 hours, and the reaction was completed After cooling to room temperature, the white product was suction-filtered, and the filter cake was washed with alcohol and water several times until it was detected as neutral by pH test paper, and finally the filter cake was dried. The resulting product is sea urchin-like hydroxyapatite (e.g. figure 1 As shown in the scanning electron microscope photo), the diameter of the sphere is 1-4 μm, the length of the whiskers on t...

Embodiment 2

[0026]Dissolve 3.0337g calcium nitrate tetrahydrate and 1.5385g urea in 15ml of deionized water; dissolve 1.0155g of diammonium hydrogen phosphate in 10ml of deionized water; dissolve 0.7692g of sorbitol in 10ml of deionized water; Add the sorbitol solution dropwise into the mixed solution of calcium nitrate tetrahydrate and urea, stir for 30 minutes, then transfer to a 50ml Teflon-lined hydrothermal kettle, react at 130°C for 20 hours, and cool to room temperature after the reaction , the white product was suction filtered, and the filter cake was washed with alcohol and water several times until it was detected as neutral by pH test paper, and finally the filter cake was dried. The resulting product is sea urchin-like hydroxyapatite (e.g. figure 2 As shown in the scanning electron microscope photo), wherein the diameter of the sphere is 1-4 μm, the length of the whiskers on the sphere is 0.5-1.5 μm, the cross-sections are all regular hexagons, and the cross-sectional diamet...

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Abstract

The present invention relates to sea urchin-like hydroxyapatite microparticles, a preparation method and an application thereof. The morphology of the hydroxyapatite microparticles of the present invention is sea urchin shape, and the structure comprises a sphere and crystal whiskers distributed on the sphere surface, wherein the sphere diameter is 1-4 mum, the crystal whisker length is 0.5-1.5 mum, and the cross-section of the crystal whisker is a regular hexagon with a diameter of 50-100 nm. The preparation method comprises: adopting a hydrolysis homogeneous precipitation method, adopting calcium nitrate tetrahydrate and ammonium dibasic phosphate as calcium and phosphorus sources, and adding urea and sorbitol, wherein a molar ratio of the calcium nitrate tetrahydrate to the urea to the ammonium dibasic phosphate to the sorbitol is (1.67-1.70):3.35:1:0.55. According to the present invention, the preparation process is simple; with establishment of a mild low oversaturation reaction environment, crystal surface energies of various crystal surfaces of the hydroxyapatite are reduced under the effect of the surfactant sorbitol, such that uniform crystallization along crystal nucleus surface active sites toward periphery can be achieved so as to form the special sea urchin shape, wherein the sea urchin-like hydroxyapatite microparticles can be used in the field of medical organic biological materials.

Description

technical field [0001] The invention relates to a hydroxyapatite particle and a preparation method thereof, in particular to a sea urchin-shaped hydroxyapatite particle and its preparation method by a hydrothermal homogeneous precipitation method and its application in medical inorganic biological materials. Background technique [0002] Hydroxyapatite is the main inorganic substance that makes up the hard tissues of living organisms. The content in human bones is about 65%, and the content in tooth enamel is as high as 97%. Since the 1970s, hydroxyapatite has become one of the focuses of research on medical inorganic biomaterials. In the application research of hydroxyapatite, the surface properties, crystallization process and biological activity of hydroxyapatite crystals with different morphologies are different. At present, the morphology of artificially synthesized hydroxyapatite is roughly needle-like, rod-like, flake-like, spherical, porous, etc. Among them, becaus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32
Inventor 李文旭王伟于倩于德珍王福平
Owner HARBIN INST OF TECH
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