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Preparation method for crosslinked gelatin antimicrobial film material

A technology of cross-linked gelatin and antibacterial film, applied in the direction of flexible coverings, packaging, wrapping paper, etc., to achieve the effect of improving mechanical properties, good film-forming properties, and low price

Inactive Publication Date: 2012-11-14
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Foreign scholars' research on antibacterial membranes is limited to the antibacterial properties of membranes and the characterization of antibacterial agent release kinetics, while the regulation of antibacterial agent diffusion behavior and related mechanisms are rarely involved.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The first step is to prepare a 5% (w / w) gelatin aqueous solution, adjust the pH of the solution to 6.5 after fully hydrating, add 40% (w / w gelatin) glycerin, and stir well;

[0028] The second step is to add lysozyme to the solution obtained in step one, and the addition amount is 50mg / 100mL (solution);

[0029] Step 3 Add proanthocyanidins to the solution obtained in step 2 in an amount of 2.0% (w / w gelatin). After the material was vacuum degassed (0.8 MPa, 3 min), 45 mL of film-forming solution was poured into a plexiglass box, and placed in a constant temperature and humidity box at 25 °C and 40% RH to dry for 36 h to form a film.

[0030] This embodiment tests the performance of composite membrane materials with different concentrations of lysozyme, including mechanical properties such as tensile strength and elongation at break, swelling rate of the membrane material, and antibacterial activity. The concentrations of lysozyme in this embodiment are respectively 40...

Embodiment 2

[0035] The first step is to prepare a 5% (w / w) gelatin aqueous solution, adjust the pH of the solution to 5.5 after fully hydrating, add 40% (w / w gelatin) glycerin, and stir well;

[0036] The second step is to add nisin into the solution obtained in step one, and the concentration is 50mg / 100mL;

[0037] Step 3 Add cross-linking agent-proanthocyanidin to the solution obtained in step 2, the concentration is 2.0% (w / w gelatin). After vacuum degassing the material (0.8MPa, 3min), measure 45mL of film-forming solution, pour it into a plexiglass box, and place it in a constant temperature and humidity box at 25°C and 40%RH to dry for 36h to form a film.

[0038] In this example, performance tests were performed on composite membrane materials with different concentrations of nisin, including mechanical properties such as tensile strength, elongation at break, swelling rate, and antibacterial activity. The concentrations of nisin in this example were respectively The test results...

Embodiment 3

[0043] The first step is to prepare a 5% (w / w) gelatin aqueous solution, adjust the pH of the solution to 6.5 after fully hydrating, add 40% (w / w gelatin) glycerin, and stir well;

[0044] The second step is to add lysozyme into the solution obtained in step one, and the concentration is respectively 50mg / 100mL;

[0045] Step 3 Add the cross-linking agent-Genipin to the solution obtained in Step 2 at a concentration of 2.0%. After the material is vacuum degassed (0.8MPa, 3min), measure 45mL of film-forming solution into a plexiglass box, place it in a constant temperature and humidity box at 25°C, 40%RH, and dry for 36h to form a film;

[0046] In this example, performance tests were performed on the composite membrane material of Genipin (Genipin) with different concentrations of cross-linking agent, including mechanical properties such as tensile strength, elongation at break, swelling rate, and antibacterial activity. In this example, Genipin The concentrations were 0.25%, 0...

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Abstract

The invention discloses a preparation method for a crosslinked gelatin antimicrobial film material. The method comprises the following steps of: (1) adding glycerol into gelatin aqueous solution; (2) adding an antimicrobial agent into the solution obtained in the step (1) and dissolving with stirring; (3) adding a crosslinking agent and reacting at the temperature of 45 to 55 DEG C for 20 to 40 minutes under the condition of magnetic stirring; and (4) performing vacuum degassing on the material obtained in the step (3) to obtain the film, wherein the antimicrobial agent is nisin or lysozyme. By the method, the release speed of the antimicrobial agent in the film material can be scientifically adjusted and the purpose of controlled release is realized. The crosslinked gelatin antimicrobial film material can be applied to an inner packaging material for food and aims to solve the food safety problem caused by that the microorganisms grow on the surface in the storage process of the food. The protein-lysozyme / nisin composite antimicrobial film material prepared by the method has great application potency of improving food quality and prolonging the shelf life of the food.

Description

technical field [0001] The invention relates to a preparation method of an antibacterial film material, in particular to a preparation method of a cross-linked gelatin antibacterial film material. Background technique [0002] Protecting the environment and saving resources has become a basic strategy for countries all over the world to achieve sustainable development. Environmental pollution and energy consumption caused by plastic products that once brought great convenience to human beings have attracted more and more attention. Due to my country's huge population base and rapid economic growth, the production and consumption of non-degradable plastics have grown explosively, which has caused serious environmental pollution and a large amount of energy consumption. Biomacromolecules such as proteins, polysaccharides and oils have good film-forming properties, biocompatibility and biodegradability, and are good substitutes for polyethylene films made of petroleum by-produ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08J3/24C08L89/00C08K5/20C08K5/1545B65D65/46
Inventor 尹寿伟马雯唐传核杨晓泉
Owner SOUTH CHINA UNIV OF TECH
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