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Amorphous calcium phosphate nanoball and preparation method thereof

A technology of amorphous calcium phosphate and nanospheres, applied in nanotechnology, nanotechnology, chemical instruments and methods, etc., can solve the problems of irregular shape of amorphous calcium phosphate, long operation time, difficult size control, etc. Drug loading capacity, good biodegradability, and the effect of improving biological properties

Active Publication Date: 2012-11-28
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example CN100428963C discloses a kind of preparation method of amorphous calcium phosphate powder, and it adopts polymers such as polyethylene glycol, homoacrylic acid as stabilizer, but polymer addition amount is big, causes cost increase and environmental pollution, and its preparation temperature limit is relatively high strict
Another example is CN100445201C discloses a kind of preparation method of nanometer amorphous calcium phosphate powder, and it adopts organic matter such as cyclodextrin as stabilizer, but this method operation time is longer
[0005] In addition, the morphology of artificially synthesized amorphous calcium phosphate is often very irregular and the size is difficult to control
There is no suitable method for preparing amorphous calcium phosphate nanospheres with regular shape, uniform size, controllable diameter and stable existence in aqueous solution for hundreds of hours.

Method used

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  • Amorphous calcium phosphate nanoball and preparation method thereof
  • Amorphous calcium phosphate nanoball and preparation method thereof
  • Amorphous calcium phosphate nanoball and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] At room temperature, 0.1470 g of CaCl 2 2H 2 O was dissolved in 30 ml of deionized water to form solution A, and 0.1102 g of adenosine triphosphate disodium salt hydrate was dissolved in 10 ml of deionized water to form solution B. After adjusting liquid A with 1 mol / L hydrochloric acid to make its pH equal to 5, add liquid B dropwise, and use magnetic stirring during this process to keep the pH at about 5. After the dropwise addition was completed, the mixed clear solution was transferred to a microwave reactor (capacity 60 ml) and reacted at 100 °C for 30 min. After the reaction system was naturally cooled to room temperature, the product was taken out and centrifuged. The separated product was washed three times with deionized water, once with absolute ethanol, and dried in air at 60°C to obtain Figure 4 In the shown calcium phosphate nanosphere powder, the average diameter of the amorphous calcium phosphate nanosphere is 260 nanometers.

Embodiment 2

[0048] At room temperature, 0.1470 g of CaCl 2 2H 2 O was dissolved in 30 ml of deionized water to form solution A, and 0.1102 g of adenosine triphosphate disodium salt hydrate was dissolved in 10 ml of deionized water to form solution B. After adjusting liquid A with 1 mol / L hydrochloric acid to make its pH equal to 5, add liquid B dropwise, and use magnetic stirring during this process to keep the pH at about 5. After the dropwise addition was completed, the mixed clear solution was transferred to a microwave reactor (capacity 60 ml) and reacted at 120 °C for 10 min. After the reaction system was naturally cooled to room temperature, the product was taken out and centrifuged. The separated product was washed three times with deionized water, once with absolute ethanol, and dried in air at 60°C to obtain Figure 5 And attached Figure 6 The shown calcium phosphate nanosphere powder, the average diameter of the amorphous calcium phosphate nanosphere is 238 nanometers, see a...

Embodiment 3

[0050] At room temperature, 0.1470 g of CaCl 2 2H 2 O was dissolved in 30 ml of deionized water to form solution A, and 0.1102 g of adenosine triphosphate disodium salt hydrate was dissolved in 10 ml of deionized water to form solution B. After adjusting liquid A with 1 mol / L hydrochloric acid to make its pH equal to 5, add liquid B dropwise, and use magnetic stirring during this process to keep the pH at about 5. After the dropwise addition was completed, the mixed clear solution was transferred into a microwave reactor (capacity 60 ml) and reacted at 120 °C for 30 min. After the reaction system was naturally cooled to room temperature, the product was taken out and centrifuged. The separated product was washed three times with deionized water, once with absolute ethanol, and dried in air at 60°C to obtain Figure 7 In the shown calcium phosphate nanosphere powder, the average diameter of the amorphous calcium phosphate nanosphere is 257 nanometers.

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Abstract

The invention relates to an amorphous calcium phosphate nanoball and a preparation method thereof. The preparation method comprises the following step of: with water-solubility calcium salt as a carbon source and phosphorus-containing biologic molecules as a phosphorus source, carrying out a hydrothermal reaction under assistance of microwaves to prepare the amorphous calcium phosphate nanoball. The amorphous calcium phosphate nanoball prepared by the method disclosed by the invention can stably exist in an aqueous solution for more than 140 hours, and can improve the biologic performance of the amorphous calcium phosphate and enhance the medicine loading capability of the calcium phosphate.

Description

technical field [0001] The invention relates to a calcium phosphate nanosphere, especially an amorphous calcium phosphate nanosphere and a preparation method thereof. It specifically relates to a preparation method for synthesizing amorphous calcium phosphate nanospheres by using phosphorus-containing biomolecules as a phosphorus source, and belongs to the field of biological material preparation. Background technique [0002] Calcium phosphate is the most important inorganic component of human bones and teeth. Synthetic calcium phosphate has a similar composition and structure to biological calcium phosphate, so it has good biological activity, biocompatibility and biodegradability, and is widely used It is used in biomedical fields such as bone substitute materials, drug delivery carriers, and gene transfection. [0003] As the initial phase of calcium phosphate deposited in aqueous solution, amorphous calcium phosphate has better biological activity and biodegradability ...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y30/00B82Y40/00
Inventor 朱英杰漆超陈峰
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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