Antradiacomphora oral liquid and preparation method thereof

An Antrodia camphorata oral liquid and filtrate technology, applied in pharmaceutical formulations, antidote, drug delivery, etc., can solve the problems of reduced active ingredient content, high energy consumption, alcohol consumption, long drying cycle, etc. Appropriate consistency and the effect of reducing energy consumption

Active Publication Date: 2014-02-19
JIANGSU SHENHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional treatment method is to concentrate the filtrate through double-effect concentration, ball pot concentration, low-temperature vacuum drying into a dry product, and mix it with the dry material of Antrodia camphorata mycelium after crushing. Hours, in the long-term drying process, the content of active ingredients in the filtrate is greatly reduced, especially the content of Antrodia camphorata polysaccharides, the yield after drying is only about 0.5g / L, and the extraction process consumes a lot of energy and alcohol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of Antrodia camphorata fermented liquid: After activating the Antrodia camphorata strain according to a conventional method, antrodia camphorata seed liquid is prepared, wherein the medium composition of Antrodia camphorata seed liquid is 6% of glucose, 2% of yeast powder, 4% of peptone, potassium dihydrogen phosphate 0.3%, magnesium sulfate 0.03%, defoamer 0.1%, prepared with water, and dilute sulfuric acid to adjust the pH value to 4.5. Specifically, use an inoculation loop to inoculate 2 to 3 loops of the activated Antrodia camphorata strain into the above-mentioned seed medium shake flask, The capacity of a 5L shake flask seed medium is 2L, cultivated at a temperature of 26-28°C for about 7 days, and the rotation speed of the shaker is 120r / min; The culture medium consists of 4% glucose, 3% yeast powder, 8% peptone, 0.3% potassium dihydrogen phosphate, 0.03% magnesium sulfate, and 0.1% defoamer, prepared with water, and adjusted to pH 4.5 with dilute sulf...

Embodiment 2

[0032] Preparation of Antrodia camphorata filtrate concentrate: The Antrodia camphorata fermented liquor prepared according to the method in Example 1 was centrifuged in a decanter centrifuge (3000 rpm) for 30 minutes, and the supernatant was taken, concentrated in a double-effect concentrator, and the concentration temperature was 60 ~75°C, the vacuum degree is not lower than -0.08Mpa, and concentrate until the specific gravity of the filtrate is 1.1 (heat measurement at 50°C) to obtain the concentrated solution of Antrodia camphorata filtrate.

[0033] Proportion of Antrodia camphorata oral liquid: Take 95kg of the above concentrate, add 4kg of sugar, 3kg of fructose syrup, 3kg of honey, 0.06kg of malic acid, and 0.08kg of xanthan gum, and mix evenly.

[0034] Sterilization and filling of oral liquid: the above-mentioned mixed liquid with good ratio was pasteurized at 100°C for 10 minutes, cooled, filled into bottles, and after passing the inspection, it was Antrodia camphora...

Embodiment 3

[0037] Preparation of Antrodia camphorata filtrate concentrate: The Antrodia camphorata fermented liquor prepared according to the method in Example 1 was centrifuged in a decanter centrifuge (3000 rpm) for 20 minutes, and the supernatant was taken, concentrated by a double-effect concentrator, and the concentration temperature was 60 ~75°C, the vacuum degree is not lower than -0.08Mpa, and concentrate until the specific gravity of the filtrate is 1.3 (heat measurement at 50°C) to obtain the concentrated solution of Antrodia camphorata filtrate.

[0038] Proportion of Antrodia camphorata oral liquid: Take 90kg of the above concentrate, add 2kg of sugar, 2kg of fructose syrup, 1kg of honey, 0.08kg of malic acid, and 1kg of xanthan gum, and mix evenly.

[0039] Sterilization and filling of oral liquid: the above-mentioned mixed liquid with good ratio was pasteurized at 100°C for 10 minutes, cooled, filled into bottles, and after passing the inspection, it was Antrodia camphorata ...

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PUM

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Abstract

The invention discloses antradiacomphora oral liquid and a preparation method thereof, wherein, the antradiacomphora oral liquid comprises the following ingredients by weight portion: 90 to 100 parts of antradiacomphora filtrate concentrated solution, 2 to 5 parts of white suga, 2 to 4 parts of high fructose corn syrup, 1 to 3 parts of honey, 0.04 to 0.1 part of hydroxy butanedioic acid, and 0.05 to 0.1 part of xanthan gum. The antradiacomphora oral liquid can greatly reserve active ingredients in antradiacomphora filtrate, achieves appropriate viscosity, good stability, long shelf life and good taste, and is suitable for being taken by large groups of people; in addition, the preparation method is simple, and is suitable for being popularized and applied.

Description

technical field [0001] The invention belongs to the technical field of medicinal fungi, and in particular relates to an antrodia camphorata oral liquid and a preparation method thereof. Background technique [0002] Antrodia camphorata is also known as camphor mushroom, camphor mushroom, antrodia cinnamomea, red camphor, camphor mushroom, camphor mushroom, camphor mushroom, red camphor. It is a unique species in Taiwan. It only grows on the inner wall of the rotten heartwood of the trunk of the unique camphor tree at an altitude of 450-2000 meters in the mountains of Taiwan, or on the dark and damp surface of the dead and fallen camphor wood. It is really not easy to find. Antrodia camphorata contains a variety of physiologically active ingredients, such as polysaccharides, triterpenoids, superoxide dismutase (SOD) adenosine, proteins (including immune proteins), multivitamins, trace elements (calcium, phosphorus), nucleic acids, agglutination Proteins, amino acids, cholest...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K36/06A61P1/16A61P3/06A61P3/10A61P31/14A61P31/20A61P35/00A61P37/04A61P39/06
Inventor 张瑞华赵禹丞徐国华袁兵兵王金恒王英燕
Owner JIANGSU SHENHUA PHARMA
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