Doxycycline hydrochloride for livestock compound injection and preparation method thereof

A doxycycline hydrochloride injection technology, applied in the field of veterinary drugs, can solve the problems of reducing the solubility, toxicity and tissue irritation of doxycycline hydrochloride, enhancing stability, and prolonging the action time, so as to achieve enhanced long-term effect Antibacterial effect, stable quality, long-term therapeutic effect

Inactive Publication Date: 2013-01-02
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of the long-acting doxycycline hydrochloride injections on the market are single preparations, often complexed with metal ions, which have a certain impact on the absorption rate, thus reducing the quick-acting properties of the drug
A kind of veterinary doxycycline hydrochloride injection disclosed by Chinese patent on November 12, 2008 (publication number: CN 101301268A) is composed of a main drug, a solvent, a complexing agent and an antioxidant, and the main drug doxycycline hydrochloride with Mg 2+ Ion complexation reduces the solubility, toxicity and tissue irritation of doxycycline hydrochloride, and enhances its stability. At the same time, α-pyrrolidone, propylene glycol, and dimethylacetamide are selected as solvents to increase the stability of the injection , which prolongs the action time of the drug and achieves the purpose of long-acting effect, but it is difficult to achieve the quick-acting effect of the drug

Method used

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  • Doxycycline hydrochloride for livestock compound injection and preparation method thereof
  • Doxycycline hydrochloride for livestock compound injection and preparation method thereof
  • Doxycycline hydrochloride for livestock compound injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The weight of each component in every 100mL injection is as follows: doxycycline hydrochloride 10g, azithromycin 5g, propylene glycol 20g, α-pyrrolidone 20g, absolute ethanol 10g, PVP K30 2g, magnesium oxide 6g, sodium formaldehyde sulfoxylate 0.3g , ethanolamine 3.2g, and the balance is water for injection.

[0019] The preparation steps are as follows:

[0020] (1) Take a small amount of water for injection, add sodium formaldehyde sulfoxylate, stir until dissolved, then add propylene glycol and α-pyrrolidone in turn, after stirring evenly, add PVP K30 and stir until dissolved;

[0021] (2) Heat the solution prepared in step (1) to 40°C, and keep the temperature at 40°C, add doxycycline hydrochloride and stir evenly, slowly add magnesium oxide, stir while adding until the addition is complete, stir for 10 minutes, Then add ethanolamine to adjust the pH value of the solution, and continue to stir until the solute is completely dissolved;

[0022] (3) Add absolute eth...

Embodiment 2

[0024] The weight of each component in every 100mL injection is as follows: doxycycline hydrochloride 5g, azithromycin 3g, propylene glycol 25g, α-pyrrolidone 15g, absolute ethanol 8g, PVP K30 1g, magnesium oxide 5g, sodium formaldehyde sulfoxylate 0.4g , ethanolamine 3.4g, and the balance is water for injection.

[0025] The preparation steps are as follows:

[0026] (1) Take a small amount of water for injection, add sodium formaldehyde sulfoxylate, stir until dissolved, then add propylene glycol and α-pyrrolidone in turn, after stirring evenly, add PVP K30 and stir until dissolved;

[0027] (2) Heat the solution prepared in step (1) to 40°C, and keep the temperature at 45°C, add doxycycline hydrochloride and stir evenly, slowly add magnesium oxide, stir until the addition is complete, and stir for 10 minutes, Then add ethanolamine to adjust the pH value of the solution, and continue to stir until the solute is completely dissolved;

[0028] (3) Add absolute ethanol to the...

Embodiment 3

[0030] The weight of each component in every 100mL injection is as follows: doxycycline hydrochloride 7g, azithromycin 4g, propylene glycol 30g, α-pyrrolidone 25g, absolute ethanol 9g, PVP K30 1.5g, magnesium oxide 5.5g, sodium formaldehyde sulfoxylate 0.5g, ethanolamine 3.5g, and the balance is water for injection.

[0031] The preparation steps are as follows:

[0032] (1) Take a small amount of water for injection, add sodium formaldehyde sulfoxylate, stir until dissolved, then add propylene glycol and α-pyrrolidone in turn, after stirring evenly, add PVP K30 and stir until dissolved;

[0033] (2) Heat the solution prepared in step (1) to 40°C, and keep the temperature at 45°C, add doxycycline hydrochloride and stir evenly, slowly add magnesium oxide, stir until the addition is complete, and stir for 10 minutes, Then add ethanolamine to adjust the pH value of the solution, and continue to stir until the solute is completely dissolved;

[0034] (3) Add absolute ethanol to ...

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Abstract

The invention discloses a doxycycline hydrochloride compound injection for livestock and a preparation method thereof, and belongs to the field of drugs for livestock. Per 100mL of the injection mainly comprises the following components, by weight: 5-10 g of doxycycline hydrochloride, 3-5 g of azithromycin, 20-30 g of propylene glycol, 15-25 g of alpha-pyrrolidone, 8-10 g of anhydrous ethanol, 1-2 g of PVP K30, 5-6 g of magnesium oxide, 0.3-0.5 g of sodium formaldehyde sulfoxylate, 3.2-3.5 g of ethanol amine, and the balance of water for injection. According to the invention, doxycycline hydrochloride and azithromycin are compounded to fully play quick-acting antibacterial activity of azithromycin on the basis of realizing long-acting antibacterial effect of doxycycline hydrochloride; drug concentration in body is effectively maintained during the application period, so as to realize efficient, quick-acting and long-acting treatment effect of the drug, and to avoid the inconvenience caused by repeated dosing by veterinary; and the prepared injection has stable quality, and has accurate and fast curative effect on livestock diseases caused by acute moderate and severe infection.

Description

technical field [0001] The invention relates to a veterinary injection, in particular to a veterinary doxycycline hydrochloride compound preparation and a preparation method thereof, belonging to the field of veterinary medicines. Background technique [0002] Doxycycline Hydrochloride (Doxycycline Hydrochloride), also known as deoxyoxytetracycline hydrochloride, is a semi-synthetic spectrum antibiotic. It is a tetracycline antibiotic obtained by transforming its molecular structure from oxycycline. Significantly enhanced, the antibacterial spectrum is the same as that of tetracycline, but its in vivo and in vitro activities are stronger than oxytetracycline and tetracycline. It is absorbed rapidly when taken orally, has high bioavailability, maintains effective blood concentration for a long time, has strong penetration into tissues, and is widely distributed. It is used to treat the infection caused by Mycoplasma, Escherichia coli, Salmonella, Pasteurella, etc. in livestoc...

Claims

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Application Information

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IPC IPC(8): A61K31/7052A61K9/08A61K47/32A61P31/04A61K31/65
Inventor 吴红云董晓盈郭俊清吴宁鹏
Owner ZHENGZHOU HOUYI PHARMA
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