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Method for preparing compound sulfachloropyridazine sodium powder

The technology of sulfachlordazine sodium and chlordazine sodium powder is applied in the field of medicines for preventing and treating Pasteurella infection of livestock and poultry, and can solve the problems of no control and prevention of Pasteurella infection of livestock and poultry, and achieves health care prevention, treatment and use safety, Enhanced drug action, diverse and convenient clinical administration methods

Inactive Publication Date: 2013-01-09
金河牧星(重庆)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Simultaneously, there is no sulfachlordazine sodium powder preparation for preventing and treating Pasteurella infection in livestock and poultry in the prior art

Method used

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  • Method for preparing compound sulfachloropyridazine sodium powder
  • Method for preparing compound sulfachloropyridazine sodium powder
  • Method for preparing compound sulfachloropyridazine sodium powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Formula

[0026] Sulfachlordazine sodium 60g, indomethacin potassium 2g, bentonite 5g, sodium citrate 5g, sodium carboxymethylcellulose 3g, sodium saccharin 2g, soluble starch 23g.

[0027] 2: Preparation method

[0028] The first step: Take bentonite, sodium citrate, and sodium carboxymethylcellulose in the prescribed amount and grind them, pass through an 80-mesh sieve after grinding, and then stir and mix for 15 minutes to obtain A powder without patterns and spots;

[0029] Step 2: Take the prescribed amount of sulfachlordazine sodium, indomethacin potassium and saccharin sodium and pulverize, pass through an 80-mesh sieve after pulverization, and then stir and mix for 15 minutes to obtain B powder without patterns and spots;

[0030] Step 3: Add the above-mentioned B powder to the A powder according to the method of equal addition and stir evenly, then add enough soluble starch and continue to stir and mix for 15 minutes. After checking and confirming that the...

Embodiment 2

[0032] 1. Formula

[0033] Sulfachlordazine sodium 62.5g, indomethacin potassium 3g, bentonite 7.5g, sodium citrate 7.5g, sodium carboxymethylcellulose 4g, sucrose 3g, anhydrous glucose 12.5g.

[0034] 2: Preparation method: the same as the method described in Example 1, only the corrective agent sodium saccharin is replaced with sucrose, and other carrier soluble starch is replaced with anhydrous glucose.

Embodiment 3

[0036] 1. Formula

[0037] Sulfachlordazine sodium 65g, indomethacin potassium 4g, bentonite 10g, sodium citrate 10g, sodium carboxymethylcellulose 5g, sucrose 4g, anhydrous glucose 2g.

[0038] 2: Preparation method: the same as the method described in Example 1, only the corrective agent sodium saccharin is replaced with sucrose, and other carrier soluble starch is replaced with anhydrous glucose.

[0039] Stability test of compound sulfachlorperazine sodium powder

[0040] 1. Materials and methods: get the compound sulfachlordazine sodium powder of embodiment 1-3, carry out high-temperature, high-humidity, and strong-light acceleration experiments according to the drug stability test method in the first appendix of "Chinese Veterinary Pharmacopoeia" 2010 edition, and pack according to commercially available , placed in a drug stability test box (Chongqing Yongsheng Experimental Instrument Factory) with a temperature of 40±2°C, a relative humidity of 75±5%, and an illuminat...

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PUM

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Abstract

The invention relates to compound sulfachloropyridazine sodium powder, and aims to provide a method for preparing compound sulfachloropyridazine sodium powder for preventing and treating livestock pasteurella infection. The method includes dispensing from 60 to 65 parts of sulfachloropyridazine sodium, from 2 to 4 parts of indometacin potassium, from 10 to 25 parts of suspending agents, from 2 to 4 parts of flavoring agents and the balance acceptable carriers; and then respectively mixing and grinding the components and mixing the components together to obtain the compound sulfachloropyridazine sodium powder. The compound sulfachloropyridazine sodium powder has an exact curative effect for various animals with pasteurellosis and is suitable to be popularized and used in animal husbandary. The sulfachloropyridazine sodium and the indometacin potassium are used compatibly, the indometacin potassium is used as an antibacterial synergist while realizing antibacterial and anti-inflammation effects, and drug effects of a main drug can be strengthened under a synergetic effect. The compound sulfachloropyridazine sodium powder can be orally taken, fed in a mixed manner and absorbed with drinking water effectively, is not easy to cause drug resistance, is safe in long-term healthcare and prevention and treatment, and has good palatability, flowability and suspension water-solubility, and various clinical administration modes of the product and convenience in administration of the product are guaranteed.

Description

technical field [0001] The invention relates to a compound sulfachlordazine sodium powder, and also relates to a medicine for preventing and treating Pasteurella infection in livestock and poultry. Background technique [0002] The antibacterial spectrum of sulfachlordazine sodium is similar to that of sulfamethoxine. It is one of the sulfa drugs with the strongest antibacterial effect in the body. It has a strong inhibitory effect on most Gram-positive and negative bacteria. Resistance is slower. The blood concentration is high, the acetylation rate is low, and it is not easy to produce crystalluria. [0003] Pasteurellosis is a septic infectious disease of various animals caused by Pasteurella multocida. When factors such as climate, seasonal changes, long-distance transportation, parasitic infection, and malnutrition lead to a decrease in animal body resistance, the Pasteurella bacteria present in the respiratory tract and tonsils of healthy carrier animals will become ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/635A61P31/04A61K31/405
Inventor 陈益德秦斌胡学全
Owner 金河牧星(重庆)生物科技有限公司
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