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Method for preparing lycoypene microcapsule

A technology of lycopene and microcapsules, which is applied in the field of preparation of lycopene microcapsules, can solve the problems that it is difficult to ensure the long-term stability of the content of water-soluble active ingredients in lycopene microcapsules, and achieve improved water solubility and stability , the effect of preventing oxidation

Active Publication Date: 2013-01-09
NANJING ZHONGKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing lycopene microencapsulation process is difficult to ensure the water solubility of lycopene microcapsules and the long-term stability of the active ingredient content

Method used

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  • Method for preparing lycoypene microcapsule
  • Method for preparing lycoypene microcapsule
  • Method for preparing lycoypene microcapsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. Core material preparation: Add 8.5g lycopene to 12.5ml salad oil, add 0.7g sucrose ester as emulsifier, stir evenly, this is oil phase A.

[0018] 2. Wall material preparation: take gelatin, broken ganoderma lucidum spore powder, sucrose, and skimmed milk powder (that is, the wall material raw material) with a weight ratio of 1:1:1:1.4, add distilled water 4 times the amount of the wall material raw material, and heat to 45 °C, stir to make it into a uniform suspension, which is oil phase B.

[0019] 3. Homogeneous emulsification: Slowly add the mixture of oil phase A and oil phase B into the water while stirring. The weight ratio of water to oil phase (that is, the sum of oil phase A and oil phase B) is 3:5, and then Place in a colloid mill and grind at 6000 rpm for 30 minutes to disperse lycopene evenly in the wall material to obtain a homogeneous emulsion.

[0020] The homogenized emulsion is spray-dried to obtain powdery lycopene microcapsules. The control cond...

Embodiment 2

[0029] 1. Core material preparation: Add 8g lycopene to 12.5ml salad oil, add 0.7g sucrose ester as emulsifier, stir well, this is oil phase A.

[0030] 2. Wall material preparation: Take gelatin, broken ganoderma lucidum spore powder, sucrose, and skimmed milk powder (that is, the wall material raw material) with a weight ratio of 1:1:1:1.2, add distilled water that is 3 times the amount of the wall material raw material, and heat to 45 °C, stir to make it into a uniform suspension, which is oil phase B.

[0031] 3. Homogeneous emulsification: Slowly add the mixture of oil phase A and oil phase B while stirring in the water. The weight ratio of water and oil phase is 3:5, and then put it in the colloid mill, under the condition of 8000 rpm Down grinding, the grinding time is 25min, that is, the lycopene is evenly dispersed in the wall material to obtain a homogeneous emulsion.

[0032] The homogenized emulsion is spray-dried to obtain a powdered lycopene product. The contro...

Embodiment 3

[0038] 1. Core material preparation: Add 9g lycopene to 12.5ml salad oil, add 0.7g sucrose ester as emulsifier, stir well, this is oil phase A.

[0039] 2. Wall material preparation: Take gelatin, broken ganoderma lucidum spore powder, sucrose, and skimmed milk powder (that is, the wall material raw material) with a weight ratio of 1:1:1:1.6, add 5 times the amount of distilled water to the wall material raw material, and heat to 40 °C, stir to make it into a uniform suspension, which is oil phase B.

[0040]3. Homogeneous emulsification: Slowly add the mixture of oil phase A and oil phase B while stirring in water. The weight ratio of water and oil phase is 3.5:5, and then put it in a colloid mill, at 5000 rpm Grinding at the bottom, the grinding time is 35min, and the lycopene is evenly dispersed in the wall material to obtain a homogeneous emulsion.

[0041] The homogenized emulsion is spray-dried to obtain a powdery lycopene product. The control conditions of spray dryin...

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Abstract

The invention discloses a method for preparing a lycoypene microcapsule. The method includes that lycoypene is prepared to be core materials and the core materials and wall materials are subjected to homogeneous emulsifying and spray drying. The wall materials are prepared by gelatins, sporoderm-broken ganoderma lucidum spore powders, cane sugars and skim milk powders, the weight ratio of the gelatins, the sporoderm-broken ganoderma lucidum spore powders, the cane sugars and the skim milk powders is 1:1:1:(1.2-1.6), and the core materials are prepared by the lycopene, salad oil and sucrose esters. According to the method for preparing the lycoypene microcapsule, a specific microcapsule technology is utilized to embed the lycoypene, the stability of the lycoypene microcapsule is improved, simultaneously the water solubility is improved, and the application field is widened.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of lycopene microcapsules. Background technique [0002] Lycopene (Lycopene) is a kind of carotenoid, which is widely found in tomatoes, watermelons, grapes, carrots and other plants. Because lycopene does not have the physiological activity of vitamin A, its role has not been taken seriously. However, studies in recent years have shown that lycopene has superior properties than other carotene, such as the ability to scavenge singlet oxygen is 100 times that of vitamin E and more than twice that of β-carotene. Lycopene can improve the body's immunity, inhibit the proliferation of cancer cells, reduce DNA loss, prevent low-density lipoprotein oxidation, and reduce blood cholesterol levels, so it can reduce the incidence of various diseases. [0003] Lycopene is usually dark red powder or oily liquid. The pure product is need...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/01A61P3/06A61P35/00A61P37/04
Inventor 冯鹏沈建钱一帆刘诚冯敏王连安
Owner NANJING ZHONGKE PHARMA
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