Application of tungsten oxide matrix nanometer materials in preparation of near-infrared light heat treatment drugs

A technology of nanomaterials and tungsten oxides, which is applied in the direction of drug combination, wave energy or particle radiation treatment materials, anti-tumor drugs, etc., can solve the problems of complex preparation process, inconsistent experimental results, and high cost, and achieve huge application value and strong Effect of near-infrared light absorption ability

Inactive Publication Date: 2013-02-13
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But gold nanostructured materials have many inherent drawbacks
For example, the near-infrared absorption of gold mainly comes from the surface plasmon resonance effect of the nanostructure, and the surface plasmon resonance effect is greatly affected by the shape and size of the nanostructure and the dielectric constant of the surrounding medium, leading to this kind of near-infrared photothermal Conversion materials are not only complicated to prepare, but also the in vivo and in vitro experimental results are inconsistent, and the treatment conditions have become quite complicated; at the same time, gold is a very expensive metal, which is not conducive to popularization and application

Method used

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  • Application of tungsten oxide matrix nanometer materials in preparation of near-infrared light heat treatment drugs
  • Application of tungsten oxide matrix nanometer materials in preparation of near-infrared light heat treatment drugs
  • Application of tungsten oxide matrix nanometer materials in preparation of near-infrared light heat treatment drugs

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Experimental program
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Effect test

Embodiment 1

[0029] Weigh 0.35g WCl 6 , into the lining of the autoclave with a solvent of 100mL, add 24mL of absolute ethanol under stirring conditions, then add 56mL of PEG400 under stirring conditions, and continue stirring for half an hour. Transfer to an autoclave and react at 180°C for 24 hours. After the reaction, centrifuge to obtain WO 2.72 (W 18 o 49 ) nanowires (see figure 1 with figure 2 ). The nanowires can be well dispersed in water and exhibit strong near-infrared light absorption properties ( image 3 a). At low power (0.72W / cm 2 ) under 980nm laser excitation, WO 2.72 Nanowires (0.25-3mg / mL) can absorb 980nm laser and generate heat effectively, and the temperature rises 12.2-41.2°C within 5min ( image 3 b). The nanomaterials were injected into the tumors of tumor-bearing mice, and then the mice's tumors were irradiated with laser light. After 10 min of laser irradiation, the mice were sacrificed by injection of anesthesia, and the tumors were removed by disse...

Embodiment 2

[0031] WO prepared with reference to the literature (Tunable Localized Surface Plasmon Resonances in Tungsten Oxide Nanocrystals, J.Am.Chem.Soc.2012,134,3995-3998) 2.83 Nanowires, the material can be well dispersed in water, showing strong near-infrared light absorption properties. At low power (0.5W / cm 2 ) under 808nm laser excitation, the WO 2.83 Nanomaterials can absorb 980nm laser and generate heat effectively, making the ambient temperature rise by 10°C within 6 minutes (see Figure 4). In particular, the nanomaterials were injected into the tumors of tumor-bearing mice, and then the mice's tumors were irradiated with laser light. After 20 min of laser irradiation, the mice were sacrificed by injecting anesthesia, and then the tumors were removed by dissection and sealed in paraffin. Cut into 4μm thin slices with a microtome, then stain the mouse tumor sections with hematoxylin-eosin staining solution, and observe with an inverted fluorescent microscope to find that t...

Embodiment 3

[0033] WO prepared with reference to the literature (Tunable Localized Surface Plasmon Resonances in Tungsten Oxide Nanocrystals, J.Am.Chem.Soc.2012,134,3995-3998) 2.8 Nanowires, the material can be well dispersed in water, showing strong near-infrared light absorption properties. At low power (0.4W / cm 2 ) under 980nm laser excitation, the WO 2.8 Nanomaterials can absorb 980nm laser light and generate heat effectively, raising the ambient temperature by 7°C within 7 minutes (see Figure 5 ). In particular, the nanomaterials were injected into the tumors of tumor-bearing mice, and then the mice's tumors were irradiated with laser light. After 20 min of laser irradiation, the mice were sacrificed by injecting anesthesia, and then the tumors were removed by dissection and sealed in paraffin. Cut into 4μm thin slices with a microtome, then stain the mouse tumor sections with hematoxylin-eosin staining solution, and observe with an inverted fluorescent microscope to find that t...

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Abstract

The invention relates to application of tungsten oxide nanometer materials in preparation of near-infrared light heat treatment drugs. The tungsten oxide matrix nanometer materials are WO3-X or MXWO3 nanometer photothermal conversion materials, wherein the WO3-X is WO 2.72 (W18O49), WO2.8 (W5O14), WO2.9 (W20O58) or WO3; and M in the MXWO3 represents chemical element of sodium (Na), potassium (K) or caesium (Cs), and X is a numerical value in the range of 0.001 to 0.5. The WO3-X and MXWO3 nanometer materials shows quite strong near-infrared light absorption ability, and is capable of effectively converting the near-infrared light into heat energy; and under the excitation of near-infrared laser, the nanometer materials can absorb the laser and effectively produce the heat energy, enables ambient temperature to rise 1-100 DEG C within 1to 60 minutes, and shows great application value in the treatment of cancer.

Description

technical field [0001] The invention belongs to the application field of tungsten oxide-based nanometer materials, and particularly relates to the application of a tungsten oxide-based nanometer material in the preparation of near-infrared photothermal diagnosis and treatment drugs. Background technique [0002] Hyperthermia has been widely used due to its minimal invasiveness, small radiation and easy operation. Among the many hyperthermia technologies, near-infrared hyperthermia has attracted more attention. Near-infrared hyperthermia is a technology that converts near-infrared light into heat energy for treatment by using the near-infrared light's deep tissue penetration ability and small tissue damage. [0003] At present, the most studied near-infrared photothermal conversion materials are mainly gold nanostructure materials, such as gold nanorods, nanospheres, nanocages, and nanohollow structures. But gold nanostructured materials have many inherent drawbacks. For e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00
Inventor 陈志钢王焕丽张丽莎胡俊青
Owner DONGHUA UNIV
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