Heteroaryl imidazolone derivatives as JAK inhibitors

A technology of heterocyclic group and solvate is applied in the field of heteroarylimidazolone derivatives as JAK inhibitors, which can solve the problems of abnormal lymphoid tissue proliferation and reduction of thymus gland size.
CN102933583AInactive Publication Date: 2013-02-13ALMIRALL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ALMIRALL
Publication Date
2013-02-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

New heteroaryl imidazolone derivatives having the chemical structure of formula (I) disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
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Description

Background technique

[0001] Cytokines play a pivotal role in regulating many aspects of immunity and inflammation, which can range from the development and differentiation of immune cells to the suppression of immune responses. Type I and type II cytokine receptors lack intrinsic enzymatic activity to mediate signal transduction and, therefore, require association with tyrosine kinases for this purpose. The JAK family of kinases includes four distinct members, namely JAK1, JAK2, JAK3 and TYK2, which control signal transduction by binding type I and type II cytokine receptors (Murray PJ, (2007). The JAK-STAT signaling pathway: input and output integration. J Immunol, 178:2623). Each JAK kinase is selective for a particular cytokine receptor. In this regard, JAK-deficient cell lines and mice have demonstrated the following important roles for each JAK protein in the receptor pathway: JAK1 binds type II cytokine receptors (IFN and IL-10 families), which share the gp130 chain (...

Claims

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