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A kind of manufacturing method of microfluidic chip mold

A technology of microfluidic chip and manufacturing method, which is applied in the direction of replication/marking method, microstructure technology, microstructure device, etc., which can solve the problems of expensive equipment processing accuracy, low structure surface flatness, long mold production cycle, etc., to achieve The effect of good flatness, shortened processing flow and time, and convenient mass production

Active Publication Date: 2016-06-08
CAPITALBIO CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the photolithography positive mold method, including the electroplating method based on photolithography, needs to be completed with professional equipment in the micro-processing workshop. The processing process is cumbersome and the cost is high, and the mold production cycle is long.
However, the equipment for micromachining is relatively expensive and due to the limitation of machining accuracy, the surface flatness of the processed structure is low
In addition, some other processing methods also have similar problems, such as 3D printing, the surface of the mold produced by it is relatively rough, and special equipment is required to complete it.
In short, the current microfluidic chip mold manufacturing method has many shortcomings such as complex processing and high cost, which limit its practical application. Therefore, it is necessary to invent an economical, simple and fast microfluidic chip mold processing method

Method used

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  • A kind of manufacturing method of microfluidic chip mold
  • A kind of manufacturing method of microfluidic chip mold
  • A kind of manufacturing method of microfluidic chip mold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1. Use a laser printer to print coated paper, and use the glycerin soaking method to make a microfluidic chip mold

[0030] Such as figure 1 As shown, the chip pattern is first printed on the coated paper using a laser printer. The area with ink on the coated paper will exhibit hydrophobic properties, while the blank area without ink (that is, the chip pattern) will exhibit hydrophilic properties. Cut the coated paper into a suitable size and immerse it in glycerin, then pick it up slowly to realize the separation of glycerin and coated paper, and then the glycerin will remain in the chip pattern area without ink, (for the convenience of observation, blue dye is added to the glycerin ). The glycerol adhered to the chip pattern will shrink due to surface tension to form a smooth arc-shaped convex structure, that is, the microfluidic chip mold is obtained.

Embodiment 2

[0031] Example 2, using a laser printer to print coated paper, using glycerin to smear and then centrifuging or gas blowing to make a microfluidic chip mold

[0032] The printing of pattern is the same as embodiment 1. Such as figure 2 As shown, a layer of glycerin will be formed by spraying or smearing on the printed coated paper, and then it will be centrifuged in a centrifuge or blown with nitrogen. If the force is small, the glycerin will be thrown away, and the glycerin will be attached to the place where there is no ink, forming the convex structure required for the mold of the microfluidic chip.

Embodiment 3

[0033] Embodiment 3, use the method of the present invention to make the PDMS chip layer that contains dimple and pipeline structure

[0034] Such as image 3 As shown, the mold made is glued to the bottom of the petri dish with double-sided adhesive, poured with PDMS prepolymer, baked in an oven at 75°C for 1 hour, and then peeled off the formed PDMS to obtain PDMS with structure chip layer. Such as Figure 4 , according to the different mask patterns, you can make patterns including pipes, micro pits and their combinations. The generated pipes and dimples have curved and smooth cross-sections, such as Figure 5 shown.

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Abstract

The invention discloses a manufacturing method of a micro-fluidic chip mold. The method comprises the following steps of: (1) printing a pattern of a prefabricated micro-fluidic chip on a paper sheet so as to form the pattern of the micro-fluidic chip on the paper sheet by ink; and (2) contacting the paper sheet treated by the step (1) with a solvent, and then separating the paper sheet from the solvent to form a convex structure on the pattern by the solvent so as to obtain the micro-fluidic chip mold of the convex structure formed by the solvent with the paper sheet as a substrate. The paper sheet and the ink have reverse hydrophilic and hydrophobic characteristics; and the solvent and the ink have reverse hydrophilic and hydrophobic characteristics. The paper sheet printing is applied to manufacturing the micro-fluidic chip mold; and batch production of the micro-fluidic chip is facilitated. The convex structure of the mold is formed by liquid; and the formed structure has a smooth surface and good flatness. The processing cost is extremely low, no special processing equipment is required, and the manufacturing method is convenient to popularize.

Description

technical field [0001] The invention relates to a method for manufacturing a microfluidic chip mold, and belongs to the technical field of microfluidic chip manufacturing. Background technique [0002] Microfluidic chip technology is based on micro-processing technology, forming a network structure such as micro-pipelines on the chip, so as to realize the controllable flow path to complete the process of material transportation, mixing and subsequent analysis, and finally realize the control of various biological A technique for the analysis of chemical and chemical processes. Microfluidic chips have attracted widespread attention due to their small sample consumption, high-efficiency and rapid biological reactions, and highly integrated and automated analysis processes. They are currently a hot research field and are widely used in biomedical research, drug screening, Clinical diagnosis, biochemical detection, forensic identification and other fields. [0003] The materia...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B81C99/00B41M5/00
Inventor 徐友春朱修锐苏世圣邢婉丽程京
Owner CAPITALBIO CORP
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