Preparation method of compound bismuth aluminate tablet

A technology of compound bismuth aluminate tablet and bismuth aluminate, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, active ingredients of aluminum/calcium/magnesium, etc. The daily production capacity cannot be met and other problems, so as to achieve the effect of solving poor safety, reducing fluctuations in the content of finished products, and avoiding hidden dangers in safe production.

Inactive Publication Date: 2013-03-13
哈药集团人民同泰医药股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the production process, even though the whole production line adopts explosion-proof equipment, the use of flammable and explosive high-concentration ethanol solution greatly reduces the safety of the production of compound bismuth aluminate tablets, which brings hidden dangers to the safe production of enterprises
However, even if a high-concentration ethanol solution preparation process is used, due to the limitations of the preparation process, the defects of the prepared particles lead to large

Method used

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  • Preparation method of compound bismuth aluminate tablet

Examples

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Comparison scheme
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Embodiment 1

[0022] A preparation method of compound bismuth aluminate sheet, comprising the following steps:

[0023] (1) Take bismuth aluminate and pass through a 120-mesh sieve, and set aside; take heavy magnesium carbonate, sodium bicarbonate, licorice extract powder, frangipani bark powder, and fennel powder, pass through a 100-mesh sieve, and set aside; take filling and diluting Agents, disintegrants and lubricants passed through a 100-mesh sieve for later use.

[0024] (2) Weigh 200g of bismuth aluminate, 400g of heavy magnesium carbonate, 200g of sodium bicarbonate, 300g of licorice extract powder, 25g of buckthorn bark powder, 20g of dextrin, and 50g of starch and mix them uniformly to obtain mixture A.

[0025] (3) Spray 45g of purified water into the mixture A in an atomized state and in a fan shape of 65 degrees, wet granulate, granulate through 16 mesh, dry the granules to a water content of 1%-7%, and granulate through 14 mesh to obtain Particle A.

[0026] (4) Mix granule ...

Embodiment 2

[0030] A preparation method of compound bismuth aluminate sheet, comprising the following steps:

[0031] (1) Take bismuth aluminate and pass through a 120-mesh sieve, and set aside; take heavy magnesium carbonate, sodium bicarbonate, licorice extract powder, frangipani bark powder, and fennel powder, pass through a 100-mesh sieve, and set aside; take filling and diluting Agents, disintegrants and lubricants passed through a 100-mesh sieve for later use.

[0032] (2) Weigh 200g bismuth aluminate, 420g heavy magnesium carbonate, 280g sodium bicarbonate, 300g licorice extract powder, 28g buckthorn bark powder, 30g dextrin, 80g lactose, 85g starch and mix evenly to obtain a mixture a.

[0033] (3) Spray 52g of purified water into the mixture A in an atomized state in a solid conical shape of 61 degrees and a fan shape of 73 degrees, and wet granulate, pass through 16 mesh for granulation, and dry the granules to a water content of 1%-7%. Granule A was obtained through 14-mesh s...

Embodiment 3

[0038] A preparation method of compound bismuth aluminate sheet, comprising the following steps:

[0039] (1) Take bismuth aluminate and pass through a 120-mesh sieve, and set aside; take heavy magnesium carbonate, sodium bicarbonate, licorice extract powder, frangipani bark powder, and fennel powder, pass through a 100-mesh sieve, and set aside; take filling and diluting Agents, disintegrants and lubricants passed through a 100-mesh sieve for later use.

[0040] (2) Weigh 150g of bismuth aluminate, 370g of heavy magnesium carbonate, 180g of sodium bicarbonate, 150g of licorice extract powder, 35g of buckthorn bark powder, 430g of lactose, and 40g of crospovidone and mix them evenly to obtain a mixture a.

[0041] (3) Spray 100g of purified water into the mixture A in an atomized state and in the form of a 60-degree hollow cone, wet granulate, pass through 20 mesh for granulation, dry the granules to a water content of 1%-7%, pass through 18 mesh for granulation Granule A wa...

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Abstract

The invention discloses a preparation method of a compound bismuth aluminate tablet. The preparation method comprises the steps of: weighing and mixing 100-300g of bismuth aluminate, 350-600g of heavy magnesium carbonate, 50-400g of sodium bicarbonate, 150-450g of licorice extract powders, 10-40g of buckthorn bark powders, 10-500g of filling diluent and 10-100g of disintegrating agent to obtain a mixture A; spraying 10-300g of adhesive in an atomization state and in a specific shape into the mixture A; pelletizing by a wet method; sifting with a sieve of 10-24 meshes; straightening particles; drying the particles till the water content is 1-7%; sifting with a sieve of 10-24 meshes; straightening particles to obtain particles A, wherein the specific shape of the adhesive in the atomization state is a sector of 0-180 degrees, a hollow cone, a solid cone or a solid square; uniformly mixing particles A, 1-30g of fennel powders and 5-25g of lubricants; tabletting; and packaging a product to obtain a finished product. According to the preparation method of the compound bismuth aluminate tablet, the safety is good, the productivity is high, the quality is stable and controllable and the effectiveness and the safety of the compound bismuth aluminate tablet can be guaranteed effectively.

Description

technical field [0001] The invention relates to a preparation method of a pharmaceutical preparation, in particular to a preparation method of compound bismuth aluminate tablets. Background technique [0002] The main ingredients of compound bismuth aluminate tablets are bismuth aluminate, heavy magnesium carbonate, sodium bicarbonate, licorice extract powder, buckthorn bark powder and fennel powder, etc. Burning sensation (heartburn), acid reflux, and also for chronic gastritis. Compound bismuth aluminate tablet is a compound preparation, and the bismuth aluminate contained in it can form a protective film on the gastric and duodenal mucosa. Sodium bicarbonate and heavy magnesium carbonate have obvious antacid effects. Cascara bark and fennel are compounded to neutralize gastric acid, eliminate flatulence and constipation, strengthen the gastric and duodenal mucosal barrier, regenerate the mucosa, and promote the healing of ulcers. Through years of clinical use, it has be...

Claims

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Application Information

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IPC IPC(8): A61K36/72A61K9/20A61P1/04A61K33/00A61K33/10A61K33/24
Inventor 刘占滨刘春凤曹林闫梅王玮
Owner 哈药集团人民同泰医药股份有限公司
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