Biocompatible water-soluble composition and use thereof

An aqueous composition and biocompatible technology, applied in the field of penetrants for medical or contraceptive rubber film products, can solve the problems of incompatibility, difficult cleaning, and difficult to remove residues, etc.

Active Publication Date: 2013-03-27
GUANGZHOU GONGHE MEDICINE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of oily lubricants has the following defects: 1) it is not compatible with the human body; 2) it is not easy to remove the residue; 3) it will leave oil stains after contacting with the skin or fabric, which is difficult to clean; 4) if it is on the skin, mucous membrane 1. Wound residues will cause various inflammations. For various medical protective sleeves, cavity inspection protective films, medical catheters, etc., lubricating oil should not be brought into the wound or body; 5) High viscosity and poor permeability, under natural infiltratio

Method used

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  • Biocompatible water-soluble composition and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Weigh 0.15g of hydroxyethyl cellulose, add 52.05g of water, continue to stir until the hydroxyethyl cellulose is completely dissolved, add 4g of L-proline, 4g of glycine, 12g of lysine, 2.5g of urea, and 0.3g of sodium benzoate , stirring and dissolving, then adding 15 g of D-panthenol, 5 g of glycerin, and 5 g of propylene glycol, stirring and dissolving, and adjusting the pH value to 5.0 with hydrochloric acid to obtain the aqueous composition of the present invention.

Embodiment 2

[0043] Weigh 0.2g of carbomer, add 52.5g of water, keep stirring until the carbomer is completely dissolved, add 15g of L-proline, 2g of urea, 0.3g of sodium benzoate, stir to dissolve, then add 20g of D-panthenol, glycerin 5g and 5g of propylene glycol were stirred and dissolved, and the pH value was adjusted to 5.5 with hydrochloric acid to obtain the aqueous composition of the present invention.

Embodiment 3

[0045] Add 5g of propylene glycol to 0.18g of methylparaben and 0.02g of propylparaben, stir until dissolved, then add 5g of glycerin, 0.15g of hydroxyethyl cellulose, and 49.15g of water, and continue stirring until the hydroxyethyl cellulose is completely dissolved , add 8g of L-proline, 10g of trimethylglycine, 2.5g of trehalose, stir to dissolve, then add 20g of D-panthenol, stir to dissolve, adjust the pH value to 6.0 with hydrochloric acid, and obtain the aqueous composition of the present invention.

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PUM

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Abstract

The invention relates to a biocompatible water-soluble composition which is prepared from the following ingredients in mass percentage: 0-60% of water-soluble amino acid, 2.5%-60% of D-panthenol, 0%-5% of a moisturizing-conditioning agent, 2.5%-20% of a polyalcohol moisturizing agent and 30%-80% of water, wherein in the case that water-soluble amino acid is contained, the total content of water-soluble amino acid and D-panthenol is not less than 5%; and in the case that water-soluble amino acid is not contained, the content of D-panthenol is not less than 5%. The invention further relates to the use of the composition as a penetrating lubricant for medical or contraceptive rubber film products. The composition disclosed by the invention is excellent in penetrating and wetting properties, lubricating and moisturizing properties, and biocompatibility, so that the rubber films present transparent and moist appearances, and can be integrally wetted in the surrounding in a forming-curling state; the whitening and the mechanical performance degradation of rubber due to long-time contact are avoided; and the advantages of wettability, lubrication, no crystallization and the like can still be kept in a drying environment.

Description

technical field [0001] The present invention relates to biocompatible aqueous compositions and uses thereof. The present invention particularly relates to an aqueous composition containing D-panthenol, or a mixture of D-panthenol and water-soluble amino acids, and a polyol humectant, and its use as a penetrating agent for medical or contraceptive rubber membrane products. Background technique [0002] Rubber medical products, such as medical catheters, medical liquid storage bags, medical membranes, covers (such as medical cavity examination finger cots, gloves, etc.), rubber surgical instruments; most of the various contraceptive products used in the lives of men and women are made of natural Natural or synthetic rubber materials, especially natural or synthetic rubber membranes. Such rubber products (especially rubber film products) are not only required to effectively block oil, germs, toxic reagents, etc. from invading and corroding the human body, but also have no harm...

Claims

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Application Information

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IPC IPC(8): A61L31/14A61L31/16A61L29/14A61L29/16A61K31/401A61K31/198A61K31/164A61P17/02A61P29/00C10M173/02C10N40/00
Inventor 梁忠品
Owner GUANGZHOU GONGHE MEDICINE TECH
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