Decoquinate oral micro-capsule preparation and preparation process thereof

A decoquinate and decoquinate technology are applied in the field of decoquinate oral microcapsule preparations and preparation thereof, and can solve the problems of poor stability, low drug load, influence on administration concentration and the like, and achieve good results. Film and formability, good biocompatibility, and the effect of improving drug loading

Inactive Publication Date: 2013-04-03
QINGDAO AGRI UNIV
View PDF3 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From a clinical point of view, the premix is ​​inconvenient to use, and it is easy to mix unevenly, thereby affecting the absorption of the drug and reducing the anti-insect effect; the solution is prepared from an organic solvent with low content and high production cost, and the organic solvent is not Easy to metabolize, easy to residue, easy to produce irritation and toxicity
In the domestic market, dosage forms such as decoquinate soluble powder and solution have been reported one afte

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Decoquinate oral micro-capsule preparation and preparation process thereof
  • Decoquinate oral micro-capsule preparation and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Add 0.08g of decoquinate raw material to 0.3ml of absolute ethanol and grind evenly, then add 10ml of 2% sodium alginate aqueous solution, grind thoroughly to obtain a stable suspension, add 0.36ml of Span-80 to 6ml of castor oil, Stir at a low speed to mix evenly, adjust the rotation speed to 1000r / min, take 2ml of the prepared drug suspension and slowly drop it into the oil phase, emulsify for 80min. Drop into the calcium chloride aqueous solution in the ratio of 1:4, stir for 50min, let it stand, and drop the lower water layer into an appropriate amount of external water phase (0.2% chitosan aqueous solution) in the ratio of 1:3, stir fully , 1.2ml glutaraldehyde for crosslinking and curing. Suction filtration, repeated washing and dehydration with petroleum ether and isopropanol, and drying at room temperature. Sodium alginate-chitosan microcapsule dry powder coated with decoquinate drug was prepared.

Embodiment 2

[0023] Add 0.04g of decoquinate raw material to 0.3ml of absolute ethanol and grind evenly, then add 10ml of 1% sodium alginate aqueous solution, grind thoroughly to obtain a stable suspension, add 0.36ml of Span-80 to 6ml of castor oil , stir at low speed to mix evenly, adjust the rotating speed to 1000r / min, take 2ml of the prepared drug suspension and slowly drop it into the oil phase, emulsify for 60min. Drop into the calcium chloride aqueous solution in the ratio of 1:4, stir for 50min, let it stand, the lower layer of water layer is dropped into the outer water phase (0.1% chitosan aqueous solution) in the ratio of 1:3, fully stir, 1.2 ml glutaraldehyde for cross-linking and curing. Suction filtration, repeated washing and dehydration with petroleum ether and isopropanol, and drying at room temperature. Sodium alginate-chitosan microcapsule dry powder coated with decoquinate drug was prepared.

Embodiment 3

[0025] Add 0.08g of decoquinate raw material to 0.3ml of absolute ethanol and grind evenly, then add 10ml of 2% sodium alginate aqueous solution, grind thoroughly to obtain a stable suspension, add 0.48ml of Span-80 to 6ml of castor, Stir at a low speed to mix evenly, adjust the rotation speed to 600r / min, take 2ml of the prepared drug suspension and slowly drop it into the oil phase, and emulsify for 80min. Drop into the calcium chloride aqueous solution in the ratio of 1:4, stir for 50min, let it stand, the lower layer of water layer is dropped into the outer water phase (0.2% chitosan aqueous solution) in the ratio of 1:3, fully stir, 1.2 ml formaldehyde for cross-linking and curing. Suction filtration, repeated washing and dehydration with petroleum ether and isopropanol, and drying at room temperature. Sodium alginate-chitosan microcapsule dry powder coated with decoquinate drug was prepared.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses a decoquinate oral micro-capsule preparation and a preparation process thereof, and in particular relates to a micro-capsule preparation, a preparation method of a novel coccidian chemical preparation for birds using decoquinate as a core material and sodium alga acid-chitosan as a composite capsule wall material, and a product, wherein the content of the alginate is 60-70 percent, the content of the chitosan is 10-20 percent, and the micro-capsule preparation is spherical or ellipsoidal and has a particle diameter of 40-80mu m. According to the invention, by coating decoquinate with sodium alga acid-chitosan, decoquinate hydrophilia is improved; and the prepared micro-capsule has a remarkable slow release function and is higher in chemical loading capacity.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and relates to a decoquinate oral microcapsule preparation and a preparation process thereof. Background technique [0002] Chicken coccidiosis is parasitic in chicken intestinal epithelial cells by one or more single-celled parasites of the genus Eimeria. Chicken coccidiosis is a parasitic disease that is extremely harmful to the chicken industry . The incidence of the disease is quite high, reaching 50% to 70%, and the mortality rate is 20% to 30%, up to 80% in severe cases. Aiming at this disease, although some coccidiosis vaccines have been successfully researched at present, they are still mainly controlled by drugs. So far, more than 40 kinds of drugs have been used to prevent and control coccidiosis. However, with the long-term and unreasonable use of coccidiostats, the occurrence of coccidian drug resistance is becoming more and more serious. The emergence of cocci...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/50A61K31/47A61K47/36A61P33/02
Inventor 邹明鄂伟刘焕奇张启迪张灿李玲
Owner QINGDAO AGRI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap