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Aliphatic polyester double-layered asymmetric guided tissue regeneration membrane and preparation method thereof

A technology that guides tissue regeneration and aliphatic polyester, applied in medical science, surgery, etc., can solve the problems of complicated post-processing measures, difficult control of membrane pore size, and low spinning efficiency, so as to achieve easy industrialization, The effect of good interlayer bonding and simple preparation method

Active Publication Date: 2014-05-14
北京市意华健科贸有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The disadvantages of the currently disclosed method for preparing a guided tissue regeneration membrane by electrospinning are that the spinning efficiency is low, the pore size of the membrane is difficult to control, and the mechanical strength of the membrane is poor. The post-processing measures are complicated, and at the same time, the thickness of the film will be increased and its flexibility will be reduced.

Method used

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  • Aliphatic polyester double-layered asymmetric guided tissue regeneration membrane and preparation method thereof
  • Aliphatic polyester double-layered asymmetric guided tissue regeneration membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Dissolve 1.411g of racemic polylactic acid (PDLLA) with a viscosity-average molecular weight of 200,000 in a mixed solvent of 9ml of chloroform and 1ml of N,N-dimethylformamide, stir magnetically at room temperature for 12h, and obtain a concentration of 9%. (w / w) polylactic acid electrospinning solution, stand at room temperature for defoaming; 2.000g polylactic acid glycolic acid copolymer (PLGA, molar ratio 50:50) with a viscosity average molecular weight of 130,000 was dissolved in 8ml tetrahydrofuran and 2mlN , in a mixed solvent of N-dimethylformamide, magnetically stirred at room temperature for 12 hours to obtain a poly(lactic-co-glycolic acid) electrospinning solution with a concentration of 0.2 g / ml, and left to stand at room temperature for defoaming;

[0025] 2. Add the polylactic acid electrospinning solution prepared in step 1 into the liquid reservoir for electrospinning. The initial voltage is 15KV, the receiving distance is 15cm, the liquid output rat...

Embodiment 2

[0032] 1. Dissolve 1.074g of racemic polylactic acid (PDLLA) with a viscosity-average molecular weight of 406,000 in a mixed solvent of 9ml of chloroform and 1ml of N,N-dimethylformamide, stir magnetically at room temperature for 12h, and obtain a concentration of 7%. (w / w) polylactic acid electrospinning solution, left standing at room temperature for defoaming;

[0033] 2. Take 5ml of the polylactic acid electrospinning solution prepared in step 1 and add it to the liquid reservoir for electrospinning. The spinning conditions are: voltage 15KV, receiving distance 20cm, liquid output rate 7ml / h, and the receiving device is tinfoil attached to the surface A rotating stainless steel disk (diameter 100mm), the disk rotating speed is 300rpm, and the obtained diameter is 100mm, and the polylactic acid electrospun membrane that thickness is 0.2mm;

[0034] 3. Place the polylactic acid electrospun membrane obtained in step 2 between two flat plates with fine patterns on the inner su...

Embodiment 3

[0040] 1. Dissolve 1.074g of racemic polylactic acid (PDLLA) with a viscosity-average molecular weight of 406,000 in a mixed solvent of 9ml of chloroform and 1ml of N,N-dimethylformamide, stir magnetically at room temperature for 12h, and obtain a concentration of 7%. (w / w) polylactic acid electrospinning solution, let it stand at room temperature for defoaming; dissolve 1.411g of racemic polylactic acid (PDLLA) with a viscosity average molecular weight of 200,000 in 9ml of chloroform and 1ml of N,N-dimethylformaldehyde In the mixed solvent of amide, stir magnetically at room temperature for 12 hours to obtain a polylactic acid electrospinning solution with a concentration of 9% (w / w), and let it stand at room temperature for defoaming;

[0041] 2. Add the polylactic acid electrospinning solution with a concentration of 7% (w / w) prepared in step 1 into the liquid reservoir for electrospinning. The initial voltage is 15KV, the receiving distance is 20cm, and the liquid output ra...

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Abstract

The invention discloses an aliphatic polyester double-layered asymmetric guided tissue regeneration membrane and a preparation method thereof. The aliphatic polyester double-layered asymmetric guided tissue regeneration membrane consists of a compact aliphatic polyester layer and a loose aliphatic polyester layer. The preparation method comprises the following steps: preparing an electrospinning liquid A and an electrospinning liquid B through aliphatic polyester; achieving electrostatic spinning film-forming through the electrospinning liquid A and obtaining the compact layer through hot-pressing; achieving electrostatic spinning film-forming on the electrospinning membrane A through the electrospinning liquid B to obtain the loose layer; achieving vacuum drying, solvent removal and freeze drying of a double-layered asymmetric electrospinning membrane; and finally achieving Co<60> radiation or ethylene epoxide sterilization of the double-layered asymmetric electrospinning membrane to obtain the double-layered asymmetric guided tissue regeneration membrane. The invention has the advantages that the preparation method is simple, the preparation efficiency is high, and the prepared membrane has favorable biocompatibility and mechanical property, appropriate degradation rate and excellent attachment property, can well satisfy the clinical requirements for guided tissue regeneration and repair, and is an ideal guided tissue regeneration membrane material.

Description

technical field [0001] The invention relates to an aliphatic polyester double-layer asymmetric guide tissue regeneration membrane and a preparation method thereof, belonging to the field of periodontal tissue repair biomedical materials and medical equipment. Background technique [0002] In the field of stomatology, periodontal tissue is generally difficult to regenerate after destruction. At present, the reconstruction and regeneration of periodontal tissue is mainly treated by guided tissue regeneration (GTR), the basic principle of which is to prevent the rapid growth of gingival epithelial cells and connective tissue by placing a physical septum between the root surface and the gingival flap. The root of the tissue grows invasively, selectively protects and promotes the periodontal specific cells to preferentially occupy the root surface, and forms a new periodontal tissue attachment device. An ideal guided tissue regeneration membrane should have good biocompatibility...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06
Inventor 肖阳范丽娟姚芳莲张二帅高志忠
Owner 北京市意华健科贸有限责任公司
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