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Medical degradable Fe-Mg-X alloy material and preparation method thereof

An alloy material, fe-mg-x technology, used in medical science, surgery, etc., can solve problems such as slow degradation rate, and achieve the effect of improving corrosion rate, avoiding pain and trouble, and good biocompatibility

Active Publication Date: 2014-08-27
SHANGHAI INNOVATON MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the defects in the prior art, the purpose of the present invention is to solve the problem that the current iron-based alloy as a degradable implant material degrades too slowly in the human body, and uses the modern powder metallurgy method-spark plasma sintering method to prepare a Medical degradable Fe-Mg-X (X = one or more of Sr, Ag, Si, Ca) alloy material, the material has high mechanical strength, suitable degradation rate and good biocompatibility, in It has important application value in the field of degradable implant materials such as bone implants and vascular stents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] This embodiment relates to a medical degradable Fe-Mg-X alloy material, which includes the following components in weight percentage: Mg is 4%, Sr is 1%, and the rest is iron.

[0040] This embodiment also relates to the preparation method of the aforementioned medical degradable Fe-Mg-X alloy material, the preparation method comprising the following steps:

[0041] The Fe-Mg-Sr ternary alloy material was prepared by SPS powder sintering. The purity of the iron powder in the original alloy material is ≥99.99%, the purity of the magnesium powder is ≥99.99%, and the strontium is added as the powder of the Mg-20Sr master alloy. Mix iron powder, magnesium powder, and Mg-Sr alloy powder according to the above weight ratio, and put them into a planetary ball mill for ball milling at a speed of 450 rpm. The ball milling method is to stop for 12 minutes every 48 minutes of ball milling, and continue ball milling for 48 hours. The alloy powder collected after ball milling was p...

Embodiment 2

[0044] This embodiment relates to a medical degradable Fe-Mg-X alloy material, which includes the following components in weight percentage: Mg is 5%, Ag is 1%, and the rest is iron.

[0045] This embodiment also relates to the preparation method of the aforementioned medical degradable Fe-Mg-X alloy material, the preparation method comprising the following steps:

[0046]The Fe-Mg-Ag alloy material was prepared by SPS powder sintering. The purity of the iron powder in the original alloy material is ≥99.99%, the purity of the magnesium powder is ≥99.99%, and the purity of the silver powder is ≥99.99%. Mix iron powder, magnesium powder and silver powder in the above weight ratio, put them into a planetary ball mill for ball milling at a speed of 450 rpm, and the ball milling method is to stop for 12 minutes every 48 minutes of ball milling, and continue ball milling for 48 hours. The alloy powder collected after ball milling was pre-pressed at 10 MPa and then placed in a spark...

Embodiment 3

[0049] This embodiment relates to a medical degradable Fe-Mg-X alloy material, which includes the following components in weight percentage: Mg is 8%, Si is 1%, and the rest is iron.

[0050] This embodiment also relates to the preparation method of the aforementioned medical degradable Fe-Mg-X alloy material, the preparation method comprising the following steps:

[0051] The Fe-Mg-Si ternary alloy material was prepared by SPS powder sintering. The purity of the iron powder in the original alloy material is ≥99.99%, the purity of the magnesium powder is ≥99.99%, and the purity of the silicon powder is ≥99.99%. Mix iron powder, magnesium powder, and silicon powder in the above weight ratio, put them into a planetary ball mill for ball milling at a speed of 450 rpm, and the ball milling method is to stop for 12 minutes every 48 minutes of ball milling, and continue ball milling for 72 hours. The alloy powder collected after ball milling was pre-pressed at 10 MPa and then place...

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Abstract

The invention discloses a medical degradable Fe-Mg-X alloy material and a preparation method thereof. The alloy material comprises the following components by weight percentage: Mg (greater than or equal to 2% and less than or equal to 10%), X (greater than 0% and less than 2%), and the balance of Fe. The invention further relates to the preparation method of the alloy material. As the alloy element Mg having a larger electrode potential difference from the matrix Fe is added, the kinetics of electrochemical corrosion of an Fe-Mg alloy matrix is improved significantly; the corrosion degradation rate of the Fe-Mg alloy matrix in an organism environment is increased greatly; and the component X having biological effects of promoting bone tissue repair, diminishing inflammation, sterilizing and the like is further added. The medical degradable Fe-Mg-X alloy material is a multielement degradable iron-base alloy material consisting of the complete-biosafety human nutrient elements Fe, Mg and X, has good biocompatibility, higher mechanical property and appropriate corrosion rate, has an important application potential in the field of medical degradable implantation materials, and has a better application prospect.

Description

technical field [0001] The invention relates to an iron-based alloy in the field of biomedical materials that can be completely degraded in vivo, specifically, a medical degradable Fe-Mg-X alloy material and a preparation method thereof. Background technique [0002] Biodegradable absorbent materials in vivo are an important direction for the development of biomaterials. Currently, biodegradable absorbent materials in clinical applications are mainly polymers and certain ceramic materials, such as polylactic acid and calcium phosphate. However, due to the low strength of polymer materials and poor plasticity and toughness of ceramic materials, their wide application is limited. In recent years, the research on a new generation of medical metal materials with biodegradable properties, mainly represented by iron-based and magnesium-based alloys, has received special attention. This new type of medical metal material has changed the traditional idea that people usually use met...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/02C22C38/00C22C38/02C22C33/02
Inventor 袁广银牛佳林
Owner SHANGHAI INNOVATON MEDICAL TECH CO LTD
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