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Detection method of medicament for treating epilepsia hyperspasmia, infantile convulsions and prosopospasm

A technology for pediatric convulsion and detection method, which is applied in the fields of hemifacial spasm capsules, Xianyu capsule detection, pediatric convulsion, and treatment of epilepsy and convulsions, can solve the problem of not formulating the identification method of salvia miltiorrhiza thin layer chromatography, etc. Curative effect, bioavailability, stable and controllable effect of quality

Inactive Publication Date: 2013-04-10
XIAN CHIHO PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the existing detection method of Xianyu Capsules, only astragaloside IV in Astragalus medicinal material was identified by thin-layer chromatography (TLC), and no thin-layer chromatography (TLC) identification method for Danshen was established

Method used

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  • Detection method of medicament for treating epilepsia hyperspasmia, infantile convulsions and prosopospasm
  • Detection method of medicament for treating epilepsia hyperspasmia, infantile convulsions and prosopospasm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Prescription and preparation method of Xianyu Capsule

[0033] 1. Prescription: Epilepsy Capsules are composed of 140g Astragalus, 140g Codonopsis, 140g Salvia, 70g Bupleurum, 105g Semen Jujube, 70g Polygala, 105g Tianma, 105g Uncaria, 105g Shichangpu, 70g Dannanxing, 140g Angelica, 105g Bombyx mori, 70g of Liushenqu, 70g of turmeric, 70g of licorice, and 35g of white aconite.

[0034] 2. Preparation method: The above sixteen flavors, silkworm, and Liu Shenqu are crushed into fine powder, sieved, and set aside; the other fourteen flavors such as astragalus are boiled in water for three times, the first time for 2 hours, the second time for 1.5 hours, and the third time After 1 hour, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a thick paste with a relative density of 1.36 (60°C), add the above-mentioned fine powder, mix well, dry in vacuum, crush into a fine powder, and prepare it with 80% ethanol Granules, dried at ...

Embodiment 2

[0035] Example 2 TLC Identification of Salvia Miltiorrhiza in Xianyu Capsules

[0036] 1. Test conditions: double-slot expansion cylinder (Shanghai Xinyi); silica gel G (for thin-layer chromatography, Qingdao Ocean Chemical Factory); sodium carboxymethyl cellulose (Sinopharm Chemical Reagent Co., Ltd.); self-made thin-layer plate, thickness 0.3mm. The rest of the reagents were analytically pure.

[0037] 2. Test steps:

[0038] Take the epilepsy capsules with batch numbers 20110202, 20110203, 20110304 and 20110305 (purchased from Xi'an Qianhe Pharmaceutical Co., Ltd., whose composition, proportioning and preparation method are as shown in Example 1) content 3g, add ether 15ml , shake, stand for 1 hour, filter, evaporate the filtrate to dryness, add 1ml of ethyl acetate to the residue to dissolve, and use it as the test solution;

[0039] Take another 1 g of Salvia miltiorrhiza as reference medicinal material, and prepare the reference medicinal material solution in the sa...

Embodiment 3

[0043] Example 3 TLC Identification of Salvia Miltiorrhiza in Xianyu Capsules

[0044] 1. Test conditions: double-slot expansion cylinder (Shanghai Xinyi); silica gel G (for thin-layer chromatography, Qingdao Ocean Chemical Factory); sodium carboxymethyl cellulose (Sinopharm Chemical Reagent Co., Ltd.); self-made thin-layer plate, thickness 0.3mm. The rest of the reagents were analytically pure.

[0045] 2. Test steps:

[0046] Take 3 g of the content of Xianyu Capsules (purchased from Xi’an Qianhe Pharmaceutical Co., Ltd.), add 15 ml of ether, shake, let stand for 1 hour, filter, evaporate the filtrate to dryness, add 1 ml of ethyl acetate to the residue to dissolve, and use it as a sample for testing. product solution;

[0047] Take another 1 g of Salvia miltiorrhiza as reference medicinal material, and prepare the reference medicinal material solution in the same way;

[0048] According to the thin-layer chromatography (see "Chinese Pharmacopoeia" 2010 Edition, Append...

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Abstract

The invention provides a detection method of a medicament for treating epilepsia hyperspasmia, infantile convulsions and prosopospasm. The detection method comprises the step of identifying red-rooted salvia root in the medicament by adopting a thin layer chromatography, wherein the conditions of the thin layer chromatography are that the mixed solution of a solution A and a solution B which are in a volume ratio of (2-6):(0.5-2), preferably 4:1, is used as a developing agent, wherein the solution A is selected from petroleum ether with a boiling range of 60-90 DEG C, petroleum ether with a boiling range of 30-60 DEG C, diethyl ether, cyclohexane, methylbenzene and benzene, preferably the solution A is the petroleum ether with a boiling range of 60-90 DEG C; and the solution B is selected from ethyl acetate, ethyl formate, acetone, chloroform and methyl alcohol, preferably ethyl acetate. The detection method has the advantages of high sensitivity, good repeatability, no interference from negative control, and strong maneuverability in the whole testing process, and can be used as one index for controlling the inherent quality.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a detection method for medicines for treating epileptic convulsions, infantile convulsions and hemifacial spasm, in particular to a capsule for treating epileptic convulsions, infantile convulsions and hemifacial spasm Agents, such as the detection method of Xianyu Capsules. Background technique [0002] Epilepsy capsules are composed of astragalus, codonopsis, salvia, bupleurum, jujube seed, polygala, gastrodia elata, uncaria, shichangpu, Dannanxing, angelica, silkworm, Liushenqu, turmeric, licorice, and aconite (made) sixteen flavors The composition of Chinese medicinal materials has synergistic effect, conforms to the principle of traditional Chinese medicine prescription, and can achieve the purpose of treating both symptoms and root causes. The preparation absorbs the essence of classic ancient prescriptions, has the effects of dispelling phlegm and resuscitati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90A61K36/9066A61K9/48A61P25/08A61P21/02
CPCA61P21/02A61P25/08G01N30/90
Inventor 胡小虎张琼吕慧锋
Owner XIAN CHIHO PHARMA
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