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Cefixime tablets and preparation method thereof

A cefixime and tablet technology, applied in the field of cefixime tablets and their preparation, can solve the problems of affecting the speed and effect of drug treatment, slow drug absorption and distribution, low dissolution rate, etc., so as to shorten the production cycle and reduce the The effect of production cost and simple production process

Active Publication Date: 2013-04-17
SUZHOU DAWNRAYS PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cefixime preparations reported in the above literature all have poor stability, low dissolution rate, slow absorption and distribution of the drug in the body, which affects the treatment speed and effect of the drug.

Method used

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  • Cefixime tablets and preparation method thereof
  • Cefixime tablets and preparation method thereof
  • Cefixime tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Dissolve 500g of cefixime and 750g of lecithin in 10L of methanol, add 200g of silicon dioxide, and stir; evaporate the methanol to dryness under reduced pressure below 50°C, take out the evaporated compound, grind it through a 80-100 mesh sieve, and obtain Cefixime phospholipid complex of silicon dioxide; weigh 145g of cefixime phospholipid complex containing silicon dioxide, mix with 55g microcrystalline cellulose, 45g lactose, 30g croscarmellose sodium, 3.5g stearin Magnesium acid is mixed evenly and directly compressed into tablets to obtain cefixime tablets.

Embodiment 2

[0023] Dissolve 500g of cefixime and 1000g of lecithin in 10L of methanol, add 250g of silicon dioxide, and stir; evaporate the methanol to dryness under reduced pressure below 45°C, take out the evaporated compound, crush it through a 80-100 mesh sieve, and obtain Cefixime phospholipid complex of silicon dioxide; weigh 175g of cefixime phospholipid complex containing silicon dioxide, mix evenly with 160g microcrystalline cellulose, 28g crospovidone, 4.0g magnesium stearate and directly press Tablets, get cefixime tablets.

Embodiment 3

[0025] Dissolve 500g of cefixime and 1250g of distearoylphosphatidylcholine in 10L of methanol, add 200g of silicon dioxide, and stir; evaporate the methanol to dryness under reduced pressure below 50°C, take out the evaporated complex, and crush it over 80- 100 mesh sieves to obtain the cefixime phospholipid complex containing silicon dioxide; weigh 195g of the cefixime phospholipid complex containing silicon dioxide, mix it with 120g microcrystalline cellulose, 45g mannitol, and 30g low-substituted hydroxypropyl fiber Plain, 4.5g magnesium stearate mix evenly direct tabletting, get cefixime tablet.

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PUM

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Abstract

The invention discloses cefixime tablets and a preparation method thereof. The cefixime tablets are formed by directly compressing silica-containing cefixime phospholipid complex and pharmaceutic adjuvant, wherein the weight ratio of the cefixime to phospholipids to silica in the silica-containing cefixime phospholipid complex is 1: (1-3): (0.2-0.8). The cefixime tablets prepared by the invention are strong in stability and high in dissolution rate, and a production process is simple.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a cefixime tablet capable of dissolving rapidly in vivo and in vitro and a preparation method thereof. Background technique [0002] The chemical name of Cefixime is: 6R, 7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(carboxymethoxyimino)acetamido]-8 -Oxo-3-ethylene-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid trihydrate, a third-generation oral cephalosporin that inhibits bacterial cell walls Synthesis of bactericidal effect. Cefixime has good effects on Gram-positive cocci such as pneumococcus and Streptococcus pyogenes in vitro and in vivo, and Gram-negative bacilli such as influenza bacilli, Moraxella catarrhalis, Escherichia coli, Proteus mirabilis, and Neisseria gonorrhoeae. Antibacterial effect; cefixime in vitro against pneumococcus, parainfluenza bacillus, Proteus vulgaris, Klebsiella pneumoniae, Pasteurella multocida, Providencia, Salmo...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/546A61K47/04A61K47/24A61P31/04
Inventor 不公告发明人
Owner SUZHOU DAWNRAYS PHARM CO LTD
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