Production method for separation and purification of salidroside from rhodiola rosea

A technology for the separation and purification of salidroside, which is applied in the direction of chemical instruments and methods, sugar derivatives, sugar derivatives, etc., and can solve the problems of high process cost, etc.

Inactive Publication Date: 2013-04-24
DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
View PDF3 Cites 24 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The salidroside extraction process in the above patent documents is mainly extracted through hot water extraction, chromatographic column separation and other steps. Although the final salidroside has a high purity, the process itself is

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh 2T of Rhodiola rosea raw material, crush it into coarse powder and pass through a 40-mesh sieve, add it from the feeding port of the elevator at a constant speed of 400kg / h, and add 75% ethanol aqueous solution through the liquid inlet pipe at a flow rate of 2T / h with a pipeline pump , the frequency of the hoist is set to 30Hz, the frequency of the host 1 is set to 20Hz, the frequency of the juicer 1 is set to 50Hz, the frequency of the host 2 is set to 22Hz, and the frequency of the juicer 2 is set to 45Hz to obtain salidroside The crude extract of salidroside is 10T; the crude extract of salidroside is self-flowed to the temporary storage tank and then continuously pumped to the concentration tank by the discharge pump to concentrate to obtain 600L of crude concentrate of salidroside; dilute the obtained concentrate with 3T of water, and filter to remove impurities The filtrate is passed through HPD400 macroporous adsorption resin, the resin column height-to-diam...

Embodiment 2

[0029] Weigh 800kg of Rhodiola rosea raw material, crush it into a coarse powder and pass it through an 80-mesh sieve, add it from the feeding port of the elevator at a constant speed of 200kg / h, and add 65% ethanol aqueous solution through the liquid inlet pipe at a flow rate of 1T / h with a pipeline pump , the frequency of the hoist is set to 25Hz, the frequency of the host 1 is set to 18Hz, the frequency of the juicer 1 is set to 50Hz, the frequency of the host 2 is set to 22Hz, and the frequency of the juicer 2 is set to 45Hz to obtain salidroside The crude extract of salidroside is 4T; the crude extract of salidroside flows to the temporary storage tank by itself and is continuously pumped to the concentration tank by the outlet pump to concentrate to obtain a crude concentrate of salidroside 250L; dilute the obtained concentrate with 1.25T of water, and remove it by filtration Impurities; the filtrate is passed through AB-8 macroporous adsorption resin, the resin column he...

Embodiment 3

[0031] Weigh 1.6T of Rhodiola rosea raw material, crush it into a coarse powder and pass through a 60-mesh sieve, add it at a constant speed of 100kg / h from the feeding port of the elevator, and use a pipeline pump to feed 75% ethanol aqueous solution through the liquid inlet pipe at a flow rate of 500kg / h Add, set the frequency of the hoist to 25Hz, the frequency of the host 1 to 18Hz, the frequency of the juicer 1 to 50Hz, the frequency of the host 2 to 22Hz, the frequency of the juicer 2 to 45Hz, and get Rhodiola Crude glycoside extract 8T; the crude salidroside extract flows to the temporary storage tank by itself and is continuously pumped to the concentration tank by the outlet pump to concentrate to obtain 500L crude salidroside concentrate; dilute the obtained concentrate with 2.5T water, filter step to remove impurities; the filtrate is passed through DM-130 macroporous adsorption resin, the resin column height-to-diameter ratio is 5:1, after the adsorption is saturate...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a production method for separation and purification of salidroside from rhodiola rosea. The method comprises the following steps: after being smashed, raw materials are thrown in from a throwing hopper; a mainframe of an extraction tank set rotates; the materials are slowly propelled from the front end of the set to the back end; and at the same time, extraction solvent is introduced in the extraction tank from a liquid inlet pipe at the tail end of the set, and penetrates the movable materials from the back end of the tank to flow to the front end; and the solid-phase and liquid-phase materials are fully contacted with each other in the inverse movement so as to extract the effective components of medicinal materials. Medicine dregs are forcedly pushed to a dreg outlet through a discharge conveyer for discharging, and are extruded by using a special juice extruder to extrude residual medicine juice from medicinal material organizations, so that the content of the residual medicine juice of the medicine dregs is reduced, the extraction efficiency is higher, and the extraction is more thorough. The method chooses macroreticular resins and combines with the silica column chromatography to purify, so that better separation effect is achieved. Finished products of salidroside with the highest yield of 1% and the content above 95% can be obtained.

Description

Technical field: [0001] The invention belongs to the field of natural organic chemistry, and relates to a production method of salidroside, in particular to a production method of separating and purifying salidroside by using a macroporous adsorption resin coupled with silica gel column chromatography. Background technique: [0002] Rhodiola rosea Latin scientific name, English name Roseroot, alias, arctic root, golden root is a perennial herb or shrub of Crassulaceae, a rare wild plant that grows in the alpine and pollution-free areas at an altitude of 800-2500 meters. Rhodiola mainly contains phenylpropanoids and flavonoids. Its unique active chemical components are phenylpropanoid esters, rosavin (the most active), rosin, rosarin, rhodiolin, salidroside and its aglycone, namely p-tyrosol. It is used for improving sleep, promoting blood circulation, anti-brain hypoxia, anti-fatigue, promoting blood circulation and stopping bleeding, clearing lung and relieving cough, redu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07H15/18C07H1/08
Inventor 姚德坤姚德利张亚红姚航黄运生吴海龙
Owner DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap