Composition for preventing hair-loss or stimulating hair growth

A hair growth and composition technology, applied in the field of compositions containing phospholipids as an active ingredient, which can solve the problems of reduced purity, high toxicity, and high cost of target products

Inactive Publication Date: 2013-05-01
BIOPID CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the reagents used to prepare finasteride are expensive or highly toxic, there are problems of high manufacturing cost and environmental pollution
In particular, there are problems in that the purity of the target product is lowered because it is difficult to remove by-products, and that it is difficult to mass-produce due to the use of reagents and active derivatives whose activity is easily inhibited by water

Method used

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  • Composition for preventing hair-loss or stimulating hair growth
  • Composition for preventing hair-loss or stimulating hair growth
  • Composition for preventing hair-loss or stimulating hair growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0116] Embodiment 1: Purify phospholipids from pig lung

[0117] Lung tissue was obtained immediately after pig slaughter at a Hazard Analysis Critical Control Point (HACCP) authorized slaughterhouse and then stored in an ice water bath. After slaughtering, use pig lung tissue within 5 hours, or store it at -20°C if not used immediately, then thaw and use it if necessary.

[0118] The extraction process of phospholipids is as follows:

[0119] 1) Grinding porcine lung tissue; 2) removing blood in lung tissue; 3) precipitating all lipids; 4) extracting all lipids with organic solvents; 5) removing neutral fats with neutral solvents; 6) in order to remove the remaining The neutral fats, peptides and proteins were purified by silica chromatographic column; 7) the solvent was removed and dried.

[0120] 1) Grinding porcine lung tissue

[0121] Hard tissue (eg, organ) or thick blood vessels (eg, aorta and pulmonary artery) were removed from the porcine lung tissue, cut into 4 ...

Embodiment 2

[0137] Embodiment 2: the preparation of composition

[0138] Since purified phospholipids exist in powder form, for application to the epidermis, phospholipids are dispersed in water. After phospholipids are dispersed in water, at 121 degrees and 15Ib / cm 2 Autoclave under pressure for 15 minutes. Divalent cations (calcium chloride or magnesium chloride) and organic acids (citric acid, maleic acid, etc.) used as cofactors were prepared as concentrated solutions, autoclaved separately, added to the dispersed phospholipid solution, and then to desired concentration. The organic acid is prepared by mixing the acid form (eg, citric acid) and the sodium salt form (eg, trisodium citrate) in a pH 5.8 buffer solution. In order to verify the effect, the concentrations of phospholipids were 5mg / ml, 10mg / ml, and 20mg / ml, the concentration of divalent cations was 1.5mM, and the concentration of organic acids (the total concentration of organic acids and organic acid salts) was finally...

experiment example 1

[0139] Experimental example 1: Test of hair growth effect: Animal experiment 1 (observation of hair growth effect)

[0140] To prepare animal samples for atopic dermatitis, or contact dermatitis and atopic dermatitis, after 1 week of sensitization with DNFB, DNFB was then applied to the back of the mice for a total of 10 times every 2 weeks to artificially induce anaphylaxis inflammation. The method of administering the material and the refined preparation showing the effect, and the description of preparing the animal sample were performed according to the previously published literature (paper) (Inagaki et al., Eur J Pharmacol, 546: 189-196). After applying DNFB for 5 times, the composition of the present invention, tacrolimus ointment (trade name, Puterpiastra Pharmaceutical Co., Ltd., South Korea), and dexamel (Sigma Chemical Co., Ltd., the United States, 0.1%) solution in ethanol) in an amount of 60 ml was applied to the back of the inflamed mice twice a day, respectiv...

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PUM

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Abstract

The present invention relates to a composition for preventing hair-loss or stimulating hair growth and containing phospholipids as an active ingredient. More particularly, the present invention relates to a composition for preventing hair-loss or stimulating hair growth and containing, as an active ingredient, phospholipids extracted from animals.

Description

technical field [0001] The present invention relates to a composition containing phospholipids as an active ingredient for preventing hair loss and promoting hair growth, and more specifically, to a composition containing animal-derived phospholipids as an active ingredient for preventing hair loss and promoting hair growth. Background technique [0002] Excessive male hormone action, poor blood circulation, decreased scalp function due to peroxides and bacteria, genetic factors, aging, stress, etc. are considered to be the cause of hair loss, but the cause of hair loss has not been known until now. In recent years, the proportion of people who are worried about hair loss has increased due to nutritional imbalances due to changes in dietary life, increased stress levels due to environmental pollution and social environments, and the age has continued to decrease, and women who are worried about hair loss The proportion of the population also gradually increased. [0003] In...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/55A61Q7/00A61Q5/00
CPCA61K8/925A61K8/553A61Q7/00A61K31/685A61P17/14
Inventor 崔性铉
Owner BIOPID CORP
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