Inhibitor of casein kinase 1[delta] and casein kinase 1[epsilon]

A technology of oxazolone and its derivatives, which can be applied in the direction of medical preparations containing active ingredients, drug combinations, cardiovascular system diseases, etc., can solve the problem that the drug treatment of pancreatic cancer has not been completed, and achieve high safety and high selectivity. Effect
CN103097380AActive Publication Date: 2013-05-08NB HEALTH LAB
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NB HEALTH LAB
Publication Date
2013-05-08

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Abstract

Provided is a novel oxazolone derivative having an inhibitory activity on casein kinase 1[delta] and casein kinase 1[epsilon]. The inhibitor can inhibit casein kinase 1[delta] and casein kinase 1[epsilon], and therefore can provide a medicinal agent useful for the treatment and / or prevention of diseases of which the disease condition are associated with the mechanism of activation of casein kinase 1[delta] or casein kinase 1[epsilon]. Particularly, the inhibitor can provide a medicinal agent useful for the treatment of circadian rhythm disorders (including sleep disorder), central nervous system degenerative diseases and cancer. An inhibitor of casein kinase 1[delta] and casein kinase 1[epsilon], which comprises an oxazolone derivative represented by general formula (1), a salt of the derivative, or a solvate or hydrate of the derivative or the salt as an active ingredient. [In formula (1), X represents a halogen atom (which may be any one of a fluorine atom, a chlorine atom, a bromine atom and an iodine atom).]
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Description

technical field

[0001] The present invention involves containing A casein kinase 1δ and casein kinase 1ε inhibitor comprising an azolone derivative or a salt thereof, a solvate thereof, or a hydrate thereof as an active ingredient. The present invention relates to medicaments for the treatment of diseases in which activation of the enzyme casein kinase 1 delta or casein kinase 1 epsilon is associated with its disease state. The present invention relates to diseases in which the enzyme activation of casein kinase 1δ or casein kinase 1ε is associated with its disease state, especially for the treatment and / or prevention of circadian rhythm cycle disorders (including sleep disorders), central nervous degenerative diseases, cancer Useful medicines for casein kinase 1 delta and casein kinase 1 epsilon inhibitors. Background technique

[0002] Casein kinase 1 is a serine / threonine kinase (and in some cases also phosphorylates tyrosine residues), known as α, β, γ1, γ2 as its iso...

Claims

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