Hydroxyl amyl benzoate potassium crystal and preparation method thereof

Abstract

The invention discloses a hydroxyl amyl benzoate potassium crystal and a preparation method thereof. The powder of the hydroxyl amyl benzoate potassium crystal disclosed by the invention has characteristic peaks under X-ray diffraction at 2theta, namely 7.0+ / -0.2 degrees and 20.9+ / -0.2 degrees. The hydroxyl amyl benzoate potassium crystal disclosed by the invention is stable in quality, stable in crystal form and more suitable for storage and use as a crude drug.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to potassium hydroxyamylbenzoate crystals and a preparation method thereof. Background technique [0002] Cerebrovascular disease (stroke) is a disease caused by blockage or rupture of cerebral blood vessels that blocks blood flow in the brain. It is divided into ischemic stroke and hemorrhagic stroke. According to reports, the results of sample surveys of urban and rural populations in my country show that the annual incidence rates are 219 / 100,000 and 185 / 100,000, respectively, and the mortality rates are 116 / 100,000 and 141.8 / 100,000, and they tend to be younger. There are about 1.5-2 million new stroke patients in my country every year, of which ischemic stroke accounts for about 60-80% of stroke cases. In 1992, among the causes of death of urban and rural population in my country, stroke ranked second, accounting for 21.13% and 16.18% of the total number of deaths...

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Problems solved by technology

The above-mentioned recrystallization solvents are highly toxic, such as chloroform, or have a low boiling point and high risk, such as ether, which are not suitable for large-scale production

In addition, Chinese patent application CN1523003A records that potassium hydroxyamylbenzoate has strong hygroscopicity, is unstable to humidity, and is easy to decompose when placed in an ordinary environment.

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