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Florfenicol dispersible tablet as well as preparation method and application thereof

A technology of florfenicol and dispersible tablets, which is applied in the direction of pill delivery and antibacterial drugs, can solve the problems of poor process stability, inconvenient injection and administration, and low oral utilization, so as to avoid adverse stress, Good practical application value and long-lasting effect

Inactive Publication Date: 2015-04-22
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug is slightly soluble in water, with low oral availability and slow onset of action
However, florfenicol injection mostly uses organic solution as solvent in the process preparation, the preparation cost is high and the process stability is not good, it is easy to separate out, and injection administration is inconvenient, and animals are prone to stress response

Method used

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  • Florfenicol dispersible tablet as well as preparation method and application thereof
  • Florfenicol dispersible tablet as well as preparation method and application thereof
  • Florfenicol dispersible tablet as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 Florfenicol dispersible tablet

[0022] prescription:

[0023] Florfenicol 150g, microcrystalline cellulose 80g, sodium carboxymethyl starch 15g, cross-linked polyvinylpyrrolidone 10g, magnesium stearate 1g.

[0024] Preparation Process:

[0025] Take cross-linked polyvinylpyrrolidone and sodium carboxymethyl starch and mix evenly, then add microcrystalline cellulose and mix evenly, then fully mix the main ingredient and auxiliary materials according to the method of equal volume addition, and use 60% v / v ethanol solution to prepare the soft material , pass through a 20-mesh sieve to granulate, dry at 60°C, pass through a 16-mesh sieve for granulation, then add magnesium stearate, mix well, and press into tablets.

Embodiment 2

[0026] The preparation of embodiment 2 Florfenicol dispersible tablets

[0027] prescription:

[0028] Florfenicol 130g, microcrystalline cellulose 100g, sodium carboxymethyl starch 18g, cross-linked polyvinylpyrrolidone 8g, magnesium stearate 2g.

[0029] Preparation Process:

[0030] Take cross-linked polyvinylpyrrolidone and sodium carboxymethyl starch and mix evenly, then add microcrystalline cellulose and mix evenly, then fully mix the main ingredient and auxiliary materials according to the method of equal volume addition, and use 50% v / v ethanol solution to prepare the soft material , pass through a 20-mesh sieve to granulate, dry at 60°C, pass through a 16-mesh sieve for granulation, then add magnesium stearate, mix well, and press into tablets.

Embodiment 3

[0031] The preparation of embodiment 3 Florfenicol dispersible tablets

[0032] prescription:

[0033] Florfenicol 170g, microcrystalline cellulose 60g, sodium carboxymethyl starch 12g, cross-linked polyvinylpyrrolidone 12g, magnesium stearate 0.5g.

[0034] Preparation Process:

[0035] Take cross-linked polyvinylpyrrolidone and sodium carboxymethyl starch and mix evenly, then add microcrystalline cellulose and mix evenly, then fully mix the main ingredient and auxiliary materials according to the method of equal volume addition, and use 70% v / v ethanol solution to prepare the soft material , pass through a 20-mesh sieve to granulate, dry at 50°C, pass through a 16-mesh sieve for granulation, then add magnesium stearate, mix well, and press into tablets to obtain.

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Abstract

The invention provides a florfenicol dispersible tablet which is a preparation prepared from the following raw and auxiliary materials in parts by weight: 130-170 parts of florfenicol, 60-100 parts of a diluent, 20-30 parts of a disintegrant and 0.5-2 parts of a lubricant. The invention also provides a preparation method and application of the dispersible tablet. The florfenicol dispersible tablet with a good dispersing effect is finally obtained through screening the raw and auxiliary materials, and the dispersible tablet is quicker in taking effects, longer in medicinal effect time, milder in plasma drug peak concentration, beneficial to reduction of toxic and side effects as well as safer and more reliable in use. Meanwhile, the florfenicol is prepared into the dispersible tablet, so that the problem such as injection liquid crystallization is solved, adverse stress generated by drug administration by injection and brought to animals is avoided, and the florfenicol dispersible tablet has a favorable actual application value.

Description

technical field [0001] The invention relates to a florfenicol dispersible tablet, a preparation method and application thereof. Background technique [0002] Florfenicol is a new veterinary-specific broad-spectrum antibacterial drug of chloramphenicol successfully developed in the late 1980s. Florfenicol is the third-generation product of chloramphenicol. The mechanism of action and antibacterial spectrum are similar to those of chloramphenicol and thiamphenicol. It can bind to 50S subunit and inhibit phthaloyltransferase, thereby inhibiting the extension of phthalein chain and interfering with protein synthesis. It is used for the prevention and treatment of asthma, contagious pleuropneumonia, atrophic rhinitis, porcine pneumonia, streptococcal disease, etc. caused by pigs, such as dyspnea, elevated body temperature, cough, choking, decreased feed intake, and emaciation. Curative effect, it has significant curative effect on yellow and white scour, enteritis, bloody dysent...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/165A61K47/38A61K47/10A61P31/04
Inventor 徐莎杨海涵房春林李超
Owner CHENGDU QIANKUN VETERINARY PHARMA