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Core/shell structured magnetic meso-porous biological active glass microsphere material and its preparation method

A technology of bioactive glass and shell structure, which can be used in wave energy or particle radiation treatment materials, drug combinations, pharmaceutical formulations, etc., and can solve problems such as regeneration of bone tissue defects

Inactive Publication Date: 2013-06-05
SUZHOU UNIV
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a magnetic mesoporous bioactive glass microsphere material with a core / shell structure and its preparation method, which can solve the problem of regenerated bone tissue defect repair while providing a drug slow-release carrier material for bone tumors problems, and at the same time can achieve combined tumor hyperthermia

Method used

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  • Core/shell structured magnetic meso-porous biological active glass microsphere material and its preparation method
  • Core/shell structured magnetic meso-porous biological active glass microsphere material and its preparation method
  • Core/shell structured magnetic meso-porous biological active glass microsphere material and its preparation method

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Embodiment 1

[0023] Embodiment one: see figure 1 shown.

[0024] First prepare the Fe 3+ ion precursor solution, and then hydrothermally synthesized colloidal carbon spheres that adsorb iron sources; the obtained colloidal carbon spheres were dispersed in polyvinylpyrrolidone (PVP) solution, and then passed through carbon-18-containing organosilane and calcium nitrate tetrahydrate, phosphoric acid Ca, P, and Si are deposited on the surface of the colloidal carbon sphere template by simultaneous hydrolysis and condensation of triacetic acid and tetraethyl orthosilicate; in terms of the amount of ions, Fe: Ca: P: Si = 10:15:5:70. Then, calcined at 700°C for 6h, then lowered the temperature to 350°C, and reduced to obtain Fe in a mixed gas atmosphere containing 5% hydrogen and 95% argon by volume. 3 o 4 MBG magnetic microspheres.

Embodiment 2

[0025] Embodiment two: see figure 1 shown.

[0026] Hydrothermal Synthesis of Fe 3 o 4 Microspheres, then disperse the microspheres in 0.1M HCl solution, wash, centrifuge, add to the PVP solution (100ml), stir for 12h, centrifuge, then add to absolute ethanol (75ml), distilled water (10ml) and Stir in the mixed solution of ammonia water (3.8ml) for 30min, then add C18TMS, calcium nitrate tetrahydrate, triethyl phosphate and ethyl orthosilicate according to the ratio of pore forming agent to calcium, phosphorus and silicon, stir for 8h, centrifuge repeatedly, Washed, dried, and sintered in a reducing atmosphere to obtain Fe 3 o 4 MBG magnetic microspheres.

[0027] attached figure 2 It is a structural diagram of the magnetic microsphere prepared in this example. The microsphere is composed of a central magnetic core and a peripheral bioactive glass. There is a cavity between the two, which can be loaded with chemotherapy drugs. The method is as follows: Dissolve the dru...

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Abstract

The invention discloses a core / shell structured magnetic meso-porous biological active glass microsphere material and its preparation method. Ca, P and Si are deposited on the surface of an iron source adsorbed colloidal carbon sphere which is treated as a template or a hydrothermal method synthesized spinel type ferrite microsphere which is treated as a core in a hydrolytic condensation mode, and sintering is carried out in a reducing atmosphere to obtain the magnetic microsphere comprising an magnetic oxide as the core and biological active glass as the shell. The core / shell structured magnetic meso-porous biological active glass microsphere material prepared in the invention simultaneously has the bone tumor medicine treatment and bone defect restoration effects to overcome the curative effect disadvantages of single methods in the bone tumor treatment, so a new idea and a new material are provided for the bone tumor treatment.

Description

technical field [0001] The invention relates to a medical slow-release carrier, in particular to a magnetic slow-release carrier for tumor drugs, especially a slow-release carrier that can be used as a bone defect repair material at the same time. Background technique [0002] Bone cancer is a very destructive malignant bone tumor, and it often occurs in adolescents. Even if it is removed by surgery immediately, the speed of its spread and metastasis is still beyond imagination. At present, in addition to surgical treatment, the commonly used methods for the clinical treatment of bone tumors include radiotherapy and chemotherapy. Among them, radiotherapy is a local treatment method, which cannot prevent the metastasis of cancer cells, and has relatively large toxic and side effects on normal tissues of the human body; while the effect of chemotherapy depends on the dose of drugs, but high-dose systemic chemotherapy often causes serious toxic and side effects. [0003] Tumor...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K41/00A61K47/02A61P35/00A61P19/08A61L27/12A61L27/54
Inventor 张英李明忠
Owner SUZHOU UNIV
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