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Spina date seed total saponin dispersible tablet and preparation method thereof

The technology of total saponins from jujube seed and jujube seed saponins is applied in the field of dispersible tablets of total saponins from jujube seed and its preparation, which can solve the problems of affecting the full absorption of drugs, slow drug dissolution of tablets, trouble for patients and the like, so as to avoid excessive local concentration. , to avoid the effect of poor stability and convenient use

Inactive Publication Date: 2013-06-12
TIANJIN UNIV OF COMMERCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tablets often affect the full absorption of drugs due to disintegration and slow drug dissolution; at the same time, when the dose is large and more drugs need to be taken at one time, it often brings troubles to the elderly, children and patients with dysphagia

Method used

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  • Spina date seed total saponin dispersible tablet and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Weigh jujube seed saponin extract 5.0g, croscarmellose sodium 3.0g, microcrystalline cellulose 10g, talcum powder 1.0g, stevioside 0.5g, and grind them through 80-mesh sieve respectively for later use.

[0024] 2. Jujube seed saponin extract is used as raw material drug, microcrystalline cellulose is used as filler, croscarmellose sodium is used as disintegrating agent, stevioside is used as flavoring agent, and 75% ethanol solution is used as The wetting agent is made into soft material, granulated with 18-mesh stainless steel sieve, the wet granules are dried in an oven at 50-60°C for 1-2 hours, and the dried granules are granulated through an 18-mesh sieve.

[0025] 3. Add talcum powder to the above-mentioned dry granules, mix evenly with the method of increasing in equal amounts, and press into tablets to make 50 dispersible tablets of total saponins of Jujube Semen.

Embodiment 2

[0027] 1. Take jujube seed saponin extract 5.0g, croscarmellose sodium 3.5g, compressible starch 5g, microcrystalline cellulose 5g, magnesium stearate 0.5g, stevioside 0.5g, and grind them respectively Finely sieve and set aside.

[0028] 2. Jujube seed saponin extract is used as the raw material drug, compressible starch and microcrystalline cellulose are used as fillers (the mass ratio of compressible starch and microcrystalline cellulose is 1:1), and cross-linked carboxymethyl Cellulose sodium is used as a disintegrating agent, stevioside is used as a flavoring agent, and 75% ethanol solution is used as a wetting agent to make a soft material, granulated with a 18-mesh stainless steel sieve, and the wet granules are dried in an oven at 50-60°C for 1 -2 hours, the dried granules are passed through a 18-mesh sieve for granulation.

[0029] 3. Add magnesium stearate to the above-mentioned dry granules, mix evenly with the method of equal increase, and tablet to make 50 Zizior...

Embodiment 3

[0031] 1. Weigh 5.0g of jujube seed saponin extract, 3.0g of croscarmellose sodium, 5g of compressible starch, 5g of microcrystalline cellulose, 1.0g of talcum powder, and 0.5g of stevioside, and grind them finely Sieve and set aside.

[0032] 2. Jujube seed saponin extract is used as the raw material drug, compressible starch and microcrystalline cellulose are used as fillers (the mass ratio of compressible starch and microcrystalline cellulose is 1:1), and cross-linked carboxymethyl Cellulose sodium is used as a disintegrating agent, stevioside is used as a flavoring agent, and 75% ethanol solution is used as a wetting agent to make a soft material, granulated with a 18-mesh stainless steel sieve, and the wet granules are dried in an oven at 50-60°C for 1 -2 hours, the dried granules are passed through a 18-mesh sieve for granulation.

[0033] 3. Add talcum powder to the above-mentioned dry granules, mix evenly with the method of increasing in equal amounts, and press into ...

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Abstract

The invention discloses a spina date seed total saponin dispersible tablet and a preparation method thereof. The dispersible tablet is characterized by convenient administration, fast dispersion, easy absorption, high bioavailability, and stable quality. The dispersible tablet comprises: 5%-30% of a spina date seed saponin extract; 10%-20% of a disintegrating agent; 1%-10% of a lubricant; 1%-5% of a flavoring agent, and the balance a filler. The preparation method consists of: weighing the spina date seed saponin extract, the disintegrating agent, and the filler, conducting grinding and sieving, then mixing them evenly; adding the flavoring agent, and taking a 50%-75% ethanol solution as a wetting agent to prepare a soft material; performing granulating, drying wet granules, and straightening dried granules; adding the lubricant, mixing them evenly by an equal increment technique, and then performing tabletting. The spina date seed saponin extract dispersible tablet disclosed in the invention has the advantages of convenient administration, fast dispersion, easy absorption, high bioavailability, and stable quality, and is particularly suitable for the elderly and people with swallowing difficulty, thus providing a new way for utilization of spina date seed total saponins.

Description

technical field [0001] The invention relates to the technical field of health food processing, in particular to a dispersible tablet of jujube seed total saponins and a preparation method thereof. Background technique [0002] With the increasingly intensified social competition, the accelerated pace of work and life, and the influence of various factors such as the environment, people are under increasing mental pressure, and the incidence of insomnia is on the rise, which has become a threat to public health. Serious Problem. Long-term insomnia can cause a series of damage to the body such as the decline of attention, judgment and memory of daily work, which seriously affects people's health, quality of life and work efficiency. Therefore, it is necessary to develop safe and effective sedative-hypnotic natural Active ingredients and their products are of great importance. [0003] Suanzaoren porridge is a traditional natural plant material with a clear effect of nourishi...

Claims

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Application Information

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IPC IPC(8): A23L1/29A23L33/00
Inventor 解军波张彦青张明春
Owner TIANJIN UNIV OF COMMERCE
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