Calcitriol enteric capsule and preparation method thereof
An enteric-coated capsule, calcitriol technology, applied in the directions of capsule delivery, bone diseases, pharmaceutical formulations, etc., can solve the problems of monotonous dosage forms, low solubility of common organic solvents, and inability to exist stably for a long time, and achieves improved bioavailability. Effect
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Embodiment 1
[0029] Embodiment 1 calcitriol enteric-coated capsule
[0030] The prescription is:
[0031] The core is made of the following components by weight percentage:
[0032]
[0033] The enteric coating layer contains 10% by weight of cellulose acetate phthalate.
[0034] The preparation method is:
[0035] 1) Weigh the raw and auxiliary materials of the prescription amount, pass through 80-mesh sieve respectively;
[0036] 2) Take the sieved starch and cellulose acetate phthalate and add distilled water respectively to make a binder solution and a coating solution;
[0037] 3) Mix the sieved calcitriol, meglumine, polyethylene glycol 400, polyethylene glycol 6000, starch and carboxymethyl starch sodium evenly in equal increments, and add the above binder solution to prepare into soft material;
[0038] 4) After granulating with a 40-mesh sieve, dry at 50°C for 30 minutes, pass through a 20-mesh sieve for granulation; then pass through a No. 4 sieve to remove fine powder, a...
Embodiment 2
[0040] Embodiment 2 calcitriol enteric-coated capsules
[0041] The prescription is:
[0042] The core is made of the following components by weight percentage:
[0043]
[0044] The enteric coating layer contains 20% by weight of cellulose acetate trimellitate.
[0045] The preparation method is:
[0046] 1) Weigh the raw and auxiliary materials of the prescription amount, and pass through a 120-mesh sieve for later use;
[0047] 2) Take the sieved pregelatinized starch and cellulose acetate trimellitate and add distilled water respectively to make a binder solution and a coating solution;
[0048] 3) Mix the sieved calcitriol, meglumine, polyethylene glycol 400, polyethylene glycol 6000, lactose and low-substituted hydroxypropyl cellulose in equal increments, and add the above binder The solution is made into a soft material;
[0049] 4) After granulating with a 40-mesh sieve, dry at 70°C for 60 minutes, pass through a 20-mesh sieve for granulation; then pass through...
Embodiment 3
[0051] Embodiment 3 calcitriol enteric-coated capsules
[0052] The prescription is:
[0053] The core is made of the following components by weight percentage:
[0054]
[0055] The enteric coating layer contains 15% by weight of hydroxypropyl cellulose phthalate.
[0056] The preparation method is:
[0057] 1) Weigh the raw and auxiliary materials of the prescription amount, pass through a 100-mesh sieve for later use;
[0058] 2) Take the sieved povidone and hydroxypropyl cellulose phthalate and add distilled water respectively to make binder solution and coating solution;
[0059] 3) Mix the sieved calcitriol, meglumine, polyethylene glycol 400, polyethylene glycol 6000, dextrin and microcrystalline cellulose evenly in an equal increment method, and add the above binder solution to prepare into soft material;
[0060] 4) After granulating with a 40-mesh sieve, dry at 60°C for 45 minutes, pass through a 20-mesh sieve for granulation; then pass through a No. 4 sieve ...
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