Purification enrichment pre-treatment technology for food packaging material and container transfer pollutant bisphenol substance

A technology for food packaging and bisphenols, which is applied in the field of purification and enrichment of bisphenols using solid phase extraction, can solve problems such as food pollution and achieve high recovery rates

Inactive Publication Date: 2013-06-19
江阴市产品质量监督检验所 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During actual use, these substances will migrate from the packaging material or container into the packaged food, causing contamination to the food

Method used

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  • Purification enrichment pre-treatment technology for food packaging material and container transfer pollutant bisphenol substance
  • Purification enrichment pre-treatment technology for food packaging material and container transfer pollutant bisphenol substance
  • Purification enrichment pre-treatment technology for food packaging material and container transfer pollutant bisphenol substance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Simultaneous detection of 6 bisphenols (BPA, BPB, BPE, BPF, BADGE and BFDGE) by HPLC-FD, the selected chromatographic column is Symmetry C 18 (4.6×250mm, 5μm); column temperature: 25°C; injection volume: 20μL; mobile phase: ultrapure water and acetonitrile; gradient elution program see Table 1; flow rate: 1.0mL / min; excitation wavelength of fluorescence detector 227nm, absorption wavelength 313nm.

[0017] The HPLC-FD spectra of 6 kinds of bisphenols are attached figure 1 , the regression equation of the quantitative standard curve is shown in Table 2.

[0018] Table 1 Gradient elution conditions

[0019]

[0020] Table 2HPLC-FD detects the linear parameters of 6 kinds of bisphenol compounds

[0021]

Embodiment 2

[0023] Six kinds of bisphenols (BPA, BPB, BPE, BPF, BADGE and BFDGE) were mixed and diluted with ultrapure water so that the concentration of each substance was 100 μg / L. Will CNWBOND LC 18 SPE small column (500mg / 3mL) was activated with 5mL methanol and 5mL water, put 100mL standard solution in a 125mL separatory funnel, slowly introduce it into the SPE device, and control the flow rate to about 2mL / min. After all the solution passed through the small column, rinse the separatory funnel with 10 mL of ultrapure water. Next, rinse the SPE cartridge with 3 mL of 20% methanol solution. Finally, 6 mL of methanol was added dropwise twice to elute the target substance, and the eluate was collected into a 10 mL test tube, blown dry slowly with nitrogen at 40°C, then reconstituted the residue with 1 mL of acetonitrile, and filtered the acetonitrile with a 0.45 μm PTFE needle filter solution, and carry out HPLC-FD detection, and assay condition is as embodiment 1. To verify the reco...

Embodiment 3

[0028] Six bisphenols (BPA, BPB, BPE, BPF, BADGE and BFDGE) were mixed and diluted with 3% acetic acid solution to make the concentrations of each substance 20 μg / L, 50 μg / L, and 100 μg / L, respectively. Will CNWBOND LC 18 The SPE cartridge (500mg / 3mL) was activated with 5mL of methanol and 5mL of water, and 100mL of the above-mentioned 3% acetic acid solution with different concentrations was placed in a 125mL separatory funnel, and slowly introduced into the SPE device, and the flow rate was controlled at about 2mL / min. After all the solution passed through the small column, rinse the separatory funnel with 10 mL of ultrapure water. Next, rinse the SPE cartridge with 3 mL of 20% methanol solution. Finally, 6 mL of methanol was added dropwise twice to elute the target substance, and the eluate was collected into a 10 mL test tube, blown dry slowly with nitrogen at 40°C, then reconstituted the residue with 1 mL of acetonitrile, and filtered the acetonitrile with a 0.45 μm PTFE...

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Abstract

The invention belongs to the technical field of purification enrichment pre-treatment for food packaging material pollutant biphenol substance. The purification enrichment pre-treatment technology comprises the following steps of: activating a C18 inverse solid phase extraction small column by methanol and ultra pure water and then loading, firstly leaching with 20% of methanol aqueous solution, then eluting with methanol, drying eluate with nitrogen in a blowing manner, redissolving residue with acetonitrile, filtering, and then carrying out liquid chromatography-fluorescence detection. By adopting the pre-treatment technology provided by the invention, recovery ratio of six biphenol substances (biphenol A (BPA), biphenol B (BPB), biphenol E (BPE), biphenol F (BPF), biphenyl A diglycidyl ether (BADGE) and biphenol F diglycidyl ether (BFDGE)) is 75.92-102.10%, relative deviation is respectivel lower than 5%, and accuracy and precision are high.

Description

technical field [0001] The invention belongs to the technical field of purification and enrichment pretreatment of food packaging materials and container migration pollutant bisphenols, and in particular relates to a purification and enrichment technical method using solid phase extraction of bisphenols. Background technique [0002] Bisphenols refer to a class of epoxy-derived substances characterized by bisphenol A (BPA) or bisphenol F (BPF) as the main structural unit, mainly including bisphenol A, bisphenol F and their derivatives. An important raw material for food contact materials such as carbonate and epoxy resin coatings. During actual use, these substances will migrate from the packaging material or container into the packaged food, causing contamination to the food. At low concentrations, bisphenols will cause certain toxicity to the human body, including acute toxicity, mutagenicity and carcinogenicity. Therefore, monitoring bisphenols in food is an important m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/06
Inventor 陈君冯怡汪仕韬卫荣鲍洋范雨豪姚卫蓉
Owner 江阴市产品质量监督检验所
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