Production method of zedoary turmeric oil microcapsule

A production method and technology of Curcuma curcumae oil, applied in the field of production of Curcuma curcuma oil microcapsules, can solve the problems of reduced efficacy, poor stability, easy to be oxidized, etc., and achieve the effects of wide sources, high medicinal value and simple preservation.

Inactive Publication Date: 2013-06-26
WUHAN KECI JUYUAN TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because zedoary oil itself has a unique smell, patients are unwilling to accept it during use, and it is not stable as a plant-extracted oil, and it is easily oxidized, and its medicinal effect is reduced after oxidation.
At present, the production methods of zedoary oil microcapsules use gelatin and β-cyclodextrin as embedding materials, but the embedding rate is not high, and the shelf life cannot reach 2 years.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh 200.00g sodium starch octenyl succinate, 150.00g zedoary oil, 50.00g mannitol, 25.00g glucose, 64.80g maltodextrin, 2.50g sodium tripolyphosphate, 5.00g sodium ascorbate, and 0.20g vitamin E , ascorbyl palmitate 0.50g, tricalcium phosphate 2.00g; Zedoary oil is heated to 50-60°C, vitamin E and ascorbyl palmitate are dissolved therein and stirred evenly, and the mixture B is obtained for subsequent use; starch sodium octenyl succinate , mannitol, maltodextrin, glucose, sodium tripolyphosphate, and sodium ascorbate were weighed and mixed in proportion, then dissolved in a certain amount of water to obtain solution A; after emulsifying and shearing solution A and mixture B for 30 minutes, use high pressure The homogenizer is used for homogenization, the homogenization pressure is 10-45MPa, and the homogenization is performed three times, so that the diameter of the emulsion droplet is less than 0.5 μm; after the homogenization, the emulsion is spray-dried, and tricalc...

Embodiment 2

[0020] Weigh 175.00g sodium starch octenyl succinate, 25.00g zedoary oil, 100.00g mannitol, 75.00g glucose, 102.35g maltodextrin, 7.50g sodium tripolyphosphate, 10.00g sodium ascorbate, and 0.40g vitamin E , ascorbyl palmitate 0.75g, tricalcium phosphate 4.00g; Curcuma oil is heated to 50-60 ℃, vitamin E and ascorbyl palmitate are dissolved therein and stirred, standby obtains mixture B; Starch sodium octenyl succinate , mannitol, maltodextrin, glucose, sodium tripolyphosphate, and sodium VC were weighed and mixed in proportion, dissolved in a certain amount of water to obtain solution A; after emulsifying and shearing solution A and mixture B for 30 minutes, use high pressure The homogenizer is used for homogenization, the homogenization pressure is 10-45MPa, and the homogenization is performed three times, so that the diameter of the emulsion droplet is less than 0.5 μm; after the homogenization, the emulsion is spray-dried, and tricalcium phosphate is evenly added on the flu...

Embodiment 3

[0022] Weigh 190.00g sodium starch octenyl succinate, 80.00g zedoary oil, 70.00 mannitol, 45.00g glucose, 98.60g maltodextrin, 5.00g sodium tripolyphosphate, 7.50g sodium ascorbate, 0.30g vitamin E, Ascorbyl palmitate 0.60g, tricalcium phosphate 3.00g; Zedoary oil is heated to 50-60°C, vitamin E and ascorbyl palmitate are dissolved therein and stirred evenly, and the mixture B is obtained for later use; Sodium starch octenyl succinate, Mannitol, maltodextrin, glucose, sodium tripolyphosphate, and sodium ascorbate were weighed and mixed in proportion, dissolved in a certain amount of water to obtain solution A; solution A and mixture B were emulsified and sheared for 30 minutes, and mixed with high pressure The homogenizer is used for homogenization, the homogenization pressure is 10-45MPa, and the homogenization is performed three times to make the emulsion droplet diameter less than 0.5 μm; after the homogenization, the emulsion is spray-dried, and tricalcium phosphate is even...

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Abstract

The invention relates to a production method of a zedoary turmeric oil microcapsule. The produced zedoary turmeric oil microcapsule comprises the following main components: 35% to 40% of starch sodium octenylsuccinate, 5% to 30% of zedoary turmeric oil, 10% to 20% of mannitol, 5% to 15% of glucose, 15% to 35% of maltodextrin, 0.5% to 1.5% of sodium tripolyphosphate, 1% to 2% of sodium ascorbate, 0.04% to 0.08% of vitamin E, 0.1% to 0.15% of magnesium ascorbyl palmitate and 0.4% to 0.8% of tricalcium phosphate. The production method has the advantages that all raw materials for preparing the zedoary turmeric oil microcapsule conform to the application range of GB2760, i.e., the raw materials are safe and reliable and can be obtained widely; the microcapsule embedding rate reaches more than 99.5%, so that the microcapsule can be directly taken orally and can also be served as the raw material for preparing capsules, suppositories and gels; and the oxidation stability of the microcapsule product is superior to that of the same-type product in the market, i.e., the microcapsule product can be stored for two years at the temperature of 37+/-2 DEG C. Therefore, the production technology can be used for producing the microcapsule which is high in medicinal value, simple to store, convenient and safe to use and low in cost.

Description

technical field [0001] The invention relates to a production method of zedoary oil microcapsules, in particular to a zedoary oil microcapsule powder obtained by embedding zedoary oil with various chemical substances as raw materials, emulsifying and homogenizing the same, and then spraying and drying. Background technique [0002] Zedoary oil has the effects of promoting blood circulation and removing blood stasis, promoting qi and breaking stagnation, eliminating stagnation and relieving pain, and mainly has anti-tumor, anti-inflammatory, anti-viral, and anti-inflammatory pharmacological effects. But because zedoary oil itself has peculiar smell, patient is unwilling to accept in use, and it is used as plant extract oil, and stability is bad, is easily oxidized, and its drug effect is reduced after oxidation. At present, the production methods of zedoary oil microcapsules use gelatin and β-cyclodextrin as embedding materials, but the embedding rate is not high, and the she...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/50A61P35/00A61P31/12A61P29/00
Inventor 简晓红
Owner WUHAN KECI JUYUAN TECH
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