Biodegradable Mg-Gd-Zn-Ag-Zr series magnesium alloy and preparation method thereof

A magnesium alloy and biological technology, applied in the field of biodegradable implant materials, can solve the problems of excessive corrosion rate, poor ductility, uneven corrosion, etc., achieve good ductility, improve toughness and corrosion resistance, and reduce stress The effect of occlusion

Inactive Publication Date: 2013-07-03
JIANGSU KONSUNG MEDICAL EQUIPMENT CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a biodegradable Mg-Gd-Zn-Ag-Zr series magnesium alloy, which can be made into intravascular Scaffolds, which degrade uniformly in the organism and corrode at an appropriate rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Use pure magnesium (the purity of Mg is greater than or equal to 99.95%), a Mg-Gd master alloy with a mass percentage of Gd of 20% (the content of impurities such as Fe, Ni, and Cu is less than 0.05%), and pure zinc (the purity of Zn is greater than or equal to 99.99%), pure silver (Ag purity greater than or equal to 99.99%), Mg-Zr master alloy with a Zr mass percentage of 20% (Fe, Ni, Cu and other impurities are less than 0.01%), according to Mg-8Gd- 1Zn-0.3Ag-0.4Zr (mass fraction) alloy composition ratio, that is, the mass percentages are Mg90.3%, Gd8%, Zn 1%, Ag 0.3%, Zr 0.4% (in this mass percentage, the Reasonable impurities are not considered, when selecting raw materials, raw materials with less impurities should be selected as much as possible).

[0028] When smelting, first add pure magnesium to the resistance furnace to melt, and the temperature of the furnace rises to 300 °C and starts to introduce CO 2 and SF 6 Mixed gas as shielding gas, CO 2 and SF 6 T...

Embodiment 2

[0030]The extruded Mg-Gd-Zn-Ag-Zr magnesium alloy in Example 1 was heat-preserved at 400° C. for 20 hours for solution treatment, and then water-cooled to room temperature. There is an LPSO structure in the extruded alloy, the room temperature yield strength is 264 MPa, the tensile strength is 352 MPa, the elongation is increased to 14.9%, the corrosion rate in the simulated body fluid is 0.41 mm / year, and the surface corrosion products are washed away. The post-corrosion surface morphology is relatively uniform, and the product has good ductility, which can be further processed into vascular stent products.

Embodiment 3

[0032] Using pure magnesium ingots, Mg-Gd master alloy (Gd mass percentage is 50%), pure zinc, pure silver, Mg-Zr master alloy (Zr mass percentage in this master alloy is 50%) as raw materials, according to Mg-8Gd-1Zn-0.3Ag-0.4Zr (mass fraction) alloy composition ratio, that is, the mass percentage content is Mg90.3%, Gd8%, Zn 1%, Ag 0.3%, Zr 0.4%, according to the composition The ratio relationship is converted into the amount of raw materials, and smelting is carried out after weighing.

[0033] When smelting, first put pure magnesium ingots into the resistance furnace to melt, and the furnace temperature rises to 300 °C and starts to introduce CO 2 and SF 6 Mixed gas, CO 2 and SF 6 The amount of gas used is 10:1; when the temperature rises to 750 ℃, add the Mg-Gd master alloy, and after it melts, start the automatic stirrer to stir for 5 minutes, then add pure Zn, pure Ag and Mg-Zr master alloy, and stir for 5 minutes - After 10 minutes, let it stand for 20-40 minutes, ...

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Abstract

The invention relates to biodegradable Mg-Gd-Zn-Ag-Zr series magnesium alloy and a preparation method thereof in the technical field of medical alloy. The alloy consists of Gd, Zn, Ag, Zr and Mg in percentage by weight: 5-10 percent of Gd, 0.5-3 percent of Zn, 0.1-1 percent of Ag, 0.1-1 percent of Zr and the balance of Mg. Through reasonably designing the alloy elements, a long-period stacking order structure (LPSO structure) is formed in an alloy structure; and with the adoption of the structure, the alloy can be strengthened and toughened, and the corrosion resistance and the local corrosion resistance of the alloy can be improved. Through deformation processing and heat treatment, the strong toughness and the corrosion resistance of the magnesium alloy can be further improved. The magnesium alloy provided by the invention is uniformly corroded in simulated body fluid, so that the overall failure of an implant material due to local corrosion is avoided, and no remarkable cytotoxicity exists; and the magnesium alloy can be used as a fixed implant material in the department of orthopedics. After solid solution treatment, the biodegradable Mg-Gd-Zn-Ag-Zr series magnesium alloy has good secondary shaping capability and can be used as an implant material in a blood vessel.

Description

technical field [0001] The invention relates to a medical alloy and a preparation method thereof, in particular to an alloy used in the field of biodegradable implant materials and a preparation method thereof. Background technique [0002] At present, the orthopedic implant materials in clinical application are mainly stainless steel and titanium alloy materials. However, stainless steel and titanium alloys are biologically inert materials, which are not degradable in the body and are prone to produce soluble ions, which can easily cause biotoxicity, local allergies or inflammation; after bone healing, a second operation is required to remove the implant material, which increases the pain of the patient , psychological and economic burdens. In addition, the elastic modulus of stainless steel and titanium alloy is much higher than that of human bone, which has a great "stress shielding" effect on local bone tissue, which may lead to the possibility of natural bone function ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C23/06C22F1/06A61L31/02A61L31/14
Inventor 章晓波王强王章忠巴志新甄睿
Owner JIANGSU KONSUNG MEDICAL EQUIPMENT CO LTD
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