A kind of small particle size konjac glucomannan microspheres with uniform size and preparation method thereof

Abstract

The invention relates to uniform-sized konjak gulcomannan microspheres. The average particle size of the microspheres is less than 10 mu m; the content of the konjak gulcomannan in the microspheres is greater than 20% (w / w); the particle size is uniform; and the particle size distribution coefficient Span value is less than 0.9. The invention further provides a preparation method of the microspheres. According to the invention, the problems that the konjak gulcomannan microspheres of which the particle size is less than 10 mu m are hard to prepare by using the conventional method and the prepared microspheres are not uniform in particle size are solved.

Description

technical field [0001] The invention relates to the field of biochemical separation and drug carrier of bioengineering, in particular, the invention relates to konjac glucomannan microspheres with uniform size and small particle size and a preparation method thereof. Background technique [0002] Konjac glucomannan (KGM) is a neutral heteropolysaccharide composed of glucose and mannose connected by β-1,4-glycosidic bonds. Its molecular structure is similar to that of dextran, and it has the ideal Many characteristics of biological materials: high hydrophilicity, good biocompatibility with biological macromolecules, rich in active hydroxyl groups in the molecules, and easy chemical modification, etc., so the prepared konjac glucomannan microspheres can be used as chromatographic media , drug controlled release carrier, fragrance adsorption carrier and other products. [0003] Because the development of konjac glucomannan microspheres has important economic and practical valu...

AI Technical Summary

Problems solved by technology

In the case of ensuring the same cross-linking effect, another way to improve the gel strength is to increase the content of konjac glucomannan in the gel microspheres, but as the concentration of glucomannan increases, the viscosity will also increase accordingly increase

At this time, it is difficult to prepare konjac glucomannan microspheres with small particle size by the traditional mechanical dispersion method and the existing direct membrane emulsification method.

Although the mechanical dispersion method can reduce the particle size by increasing the stirring speed, the particle size distribution obtained by the dispersion method is very wide, and there are still very few microspheres smaller than 10 μm

For the existing direct membrane emulsification method, when preparing konjac glucomannan gel microspheres, the increase of the viscosity of the aqueous phase will bring great trouble to the preparation process of the emulsion, and the larger viscosity of the aqueous phase will make the generated droplets It is difficult to fall off the surface of the membrane. When the droplet size is small, it will even block the membrane pores after a long emulsification process.

At the same time, studies have also shown that the larger viscosity of the aqueous phase makes the preparation process quite slow even under high pressure.

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