Method for preparing spliced artificial bone-filled sustained-release material with treatment effect

A therapeutic effect, artificial bone technology, applied in the field of nano biomedicine, to achieve anti-infective bone regeneration, prolong operation time, and promote bone regeneration.

Inactive Publication Date: 2013-08-21
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In summary, in the reports of the existing literature, there is no information about the biocompatibility and biodegradable nanomaterials described in the present invention as carrier attachments, made of nanofiber films by electrospinning technology, and special powders Co-pressed to form artificial bone filling material with long-term sustained release effect and rapid splicing to achieve different therapeutic effects and enhance the traction resistance of the repaired bone site, and prevent related research reports on muscle atrophy and functional degradation of the affected limb

Method used

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  • Method for preparing spliced artificial bone-filled sustained-release material with treatment effect
  • Method for preparing spliced artificial bone-filled sustained-release material with treatment effect
  • Method for preparing spliced artificial bone-filled sustained-release material with treatment effect

Examples

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Embodiment 1

[0030]Accurately weigh 0.24g of PCL with a molecular weight of 80,000, 0.012g of rifampicin powder, add chloroform that is 100 / 7 times the total amount of PCL and rifampicin, and the obtained solution has a voltage of 15kv and a flow rate of 0.5ml / h. Under the condition of spinning for 4 hours, a drug film containing rifampicin was obtained. Accurately weigh 0.24g of PCL with a molecular weight of 80,000, and 0.012g of isoniazid powder, add a mixture of 100 / 7 times the total amount of PCL and isoniazid (chloroform:DMF=9:1), and the obtained solution is Spinning for 4 hours under the conditions of 15kv and flow rate of 0.5ml / h, the drug film containing isoniazid was obtained. The powder is mixed and ground according to the ratio of TCP:HA:PCL:NaCl=(0.4:0.6:1:8) to obtain a special powder. Accurately weigh 0.1g of the special powder and place it in the mold, add isoniazid drug film matching the size of the mold, add 0.1g of the special powder, add rifampicin drug film matching ...

Embodiment 2

[0032] Accurately weigh chitosan 0.24g, penicillin powder 0.012g, add chitosan and penicillin 100 / 7 times the total amount of chloroform, the solution obtained is 12kv at a voltage, and the flow rate is 1ml / h for spinning for 3h. A drug film containing penicillin was obtained. The powder is mixed and ground according to the ratio of BMP2:HA:PCL:NaCl=(0.4:0.6:1:8) to obtain a special powder. Accurately weigh 0.1g of the special powder and place it in the mold, add isoniazid drug film that matches the size of the mold, add 0.1g of the special powder, add the drug film that matches the size of the mold, add 0.1g of the special powder, and add the film that matches the size of the mold Add 0.1g of special powder, add a film that matches the size of the mold, add 0.1g of special powder, add a film that matches the size of the mold, add 0.1g of special powder, add a film that matches the size of the mold, add Special powder 0.1g. Place it together with the mold at 80°C for 20 minu...

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Abstract

The invention belongs to the field of nanobiomedicine, and particularly relates to a method for preparing a spliced artificial bone-filled sustained-release material with a treatment effect. The method comprises the steps of by taking biodegradable nano-materials with biocompatibility as carrier attachments, spinning a film from mixing solution in which a medicine is loaded by an electrospinning technique; and alternatively pressing and forming the film and special powder at an interval, so as to obtain an artificial bone filler which has long-term sustained-release property and treatment effect, and can be mutually spliced. The artificial bone-filled sustained-release material disclosed by the invention has good biocompatibility and biodegradability, can achieve the treatment effect by controlled release of the loaded medicine; the artificial bone can be mutually spliced, and can be conveniently clinically spliced into different shapes according to difference of bone defects; and the stress intensity and the traction resistance of the artificial bone can be strengthened in difference directions according to different splicing methods.

Description

technical field [0001] The invention belongs to the field of nano-biomedicine, and in particular relates to a preparation method of a spliced ​​artificial bone filling sustained-release composite material with therapeutic effect. Background technique [0002] Bone defect refers to the destruction of the structural integrity of the bone, which is a common clinical disease. Trauma, infection, tumor, surgical debridement of osteomyelitis, and various congenital diseases are the main causes of bone defects. Smaller bone defects (usually below 8mm) may heal on their own for a healthy non-smoker; but too large a bone defect, or a bone defect on a smaller bone, is difficult to heal completely, Surgical intervention is required, the main methods are as follows: [0003] 1. Bone transplantation is divided into autologous bone transplantation, allogeneic bone transplantation and xenogeneic bone transplantation. Although autologous bone grafting has obvious advantages, such as no re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/12A61L27/02A61L27/22A61L27/18A61L27/20
Inventor 赵鹏邓翠君林超文学军
Owner TONGJI UNIV
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