High-strength, high-elasticity and degradable artificial cardiovascular stent and preparation method thereof

A high-elasticity, high-strength technology, applied in braids, medical science, fiber types, etc., can solve problems such as low strength and uncontrollable degradation, and achieve the effect of inhibiting bacteria, high strength, and high elasticity

Inactive Publication Date: 2013-09-04
INST OF CHEM CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of low strength and local inflammatory response caused by uncontrollable degradation of the degradable artificial cardiovascular stent, the present invention provides a high-strength, high-elasticity, degradable artificial cardiovascular stent to promote the clinical application of the artificial heart stent

Method used

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  • High-strength, high-elasticity and degradable artificial cardiovascular stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) The polylactic acid-chitosan fiber with a fineness of 100dtex (the mass ratio of polylactic acid and chitosan is 50:50) is pulled out from the spool at a speed of 10m / min after being twisted three times and passed through a high-speed braiding machine The guide wheel guides to the weaving point and is woven into a hollow braided rope;

[0030] (2) Put the hollow braided rope prepared by step (1) on the outside of a stainless steel wire with a diameter of 3mm and a length of 50cm, and process the braided rope with a drum type microwave continuous heater; the microwave output power is 450w, and the heating temperature is 100°C ;

[0031] (3) Polyglycolic acid-chitosan (the mass ratio of polyglycolic acid and chitosan is 50:50) and polyethylene glycol (molecular weight is 2000) is dissolved in tetrahydrofuran with 40:8 (mass ratio), The concentration of the solution formed is 50%;

[0032] (4) Coating the casting solution prepared in step (3) on the surface of the ho...

Embodiment 2

[0034] (1) The polylactic acid-chitosan fiber with a fineness of 300dtex (the mass ratio of polylactic acid and chitosan is 90:10) is twisted twice and pulled out from the bobbin at a speed of 1m / min. The guide wheel of the machine guides to the weaving point and weaves into a hollow braided rope;

[0035] (2) the hollow braided rope that step (1) is made is worn on diameter 0.1mm, and length is outside the stainless steel wire of 30cm, and process braided rope with drum type microwave continuous heater; Microwave output power is 200w, and heating temperature is 150 ℃;

[0036] (3) Polyglycolic acid-chitosan (the mass ratio of polyglycolic acid and chitosan is 70:30) and polyethylene glycol (molecular weight is 800) are dissolved in acetone with 20:2 (mass ratio), The concentration of the formed solution is 10%;

[0037] (4) Coating the casting solution prepared in step (3) on the surface of the hollow braided rope obtained in step (2), then placing it in water for solidific...

Embodiment 3

[0039] (1) The poly(lactic acid-glycolic acid)-chitosan fiber (the mass ratio of poly(lactic acid-glycolic acid) and chitosan is 80:20) fiber with a fineness of 70dtex is twisted for 3 times and then twisted at a rate of 5m / The speed of min is pulled out from the bobbin and guided to the braiding point through the guide wheel of the high-speed braiding machine, and braided into a hollow braided rope;

[0040] (2) the hollow braided rope that step (1) is made is worn on the diameter 1.5mm, and the stainless steel wire that length is 2cm outside, and process braided rope with drum type microwave continuous heater; Microwave output power is 300w, and heating temperature is 120 ℃;

[0041] (3) Dissolve polyglycolic acid-chitosan (the mass ratio of polyglycolic acid and chitosan is 60:40) and polyethylene glycol (molecular weight is 1000) in ethyl acetate with 30:5 (mass ratio) In, the concentration of the solution formed is 30%;

[0042] (4) Coating the casting solution prepare...

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Abstract

The invention provides a high-strength, high-elasticity and degradable artificial cardiovascular stent and a preparation method thereof. The stent consists of a degradable internally-supported woven structure and a surface porous composite layer; and the preparation method for the high-strength, high-elasticity and degradable artificial cardiovascular stent comprises the following steps of: weaving a hollow rope structure by using degradable fibers, and then coating a degradable material on the surface of the woven hollow rope to form a porous surface layer. The stent is completely made of biocompatible degradable materials; and through the special internally-supported woven rope structure and the surface porous structure, the stent has high strength and elasticity and good biocompatibility, and solves the problems that an artificial cardiovascular stent is low in strength in the using process, injures blood vessels and body tissues, needs lifetime anticoagulation after being used and the like.

Description

technical field [0001] The invention relates to a high-strength, high-elasticity, degradable artificial cardiovascular support and a preparation method thereof. Background technique [0002] With the acceleration of population aging, the incidence of cardiovascular disease, especially coronary heart disease, is increasing and has become one of the major diseases threatening human health. At the beginning of the 21st century, about 17 million people die from cardiovascular diseases worldwide each year, accounting for about 1 / 3 of the global death toll, 80% of which are distributed in low- and middle-income countries. It is estimated that the number of deaths will increase by 50% by 2020, reaching 25 million people per year. Therefore, the prevention and treatment of cardiovascular diseases has become the focus of attention of the medical circles at home and abroad. [0003] Percutaneous transluminal coronary angioplasty (PTCA for short), developed in the middle and late 1970...

Claims

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Application Information

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IPC IPC(8): A61L31/14A61L31/04D04C1/12D06M15/507D06M15/03D06M15/53D06M101/32
Inventor 刘必前何敏张海军李青峰陈亮葛均波
Owner INST OF CHEM CHINESE ACAD OF SCI
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