Antibiotic premixing agent for inhibiting porcine reproductive and respiratory syndrome virus for livestock and preparation method thereof

A technology of premix and mycocin, applied in antiviral agents, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve problems such as unfavorable therapeutic effects, increase the number of administrations, and affect animal feed intake, etc., to achieve change Drug release rate, increasing molecular force, increasing the effect of drug dissolution rate

Active Publication Date: 2013-09-18
武汉回盛生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the acetylisovaleryl tylosin tartrate premix is ​​mainly fed and administered through mixing materials, but the acetylisovaleryl tylosin tartrate raw material has a strong smell, a bitter tas

Method used

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  • Antibiotic premixing agent for inhibiting porcine reproductive and respiratory syndrome virus for livestock and preparation method thereof
  • Antibiotic premixing agent for inhibiting porcine reproductive and respiratory syndrome virus for livestock and preparation method thereof
  • Antibiotic premixing agent for inhibiting porcine reproductive and respiratory syndrome virus for livestock and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A veterinary acetylisovaleryl tylosin tartrate premix, the preparation method of which is as follows:

[0038] (1) Stir and mix 10 g of acetylisovaleryl tylosin tartrate API and 10 g of polyacrylic acid resin II for 30 minutes to make a drug-coated carrier mixture;

[0039] (2) Add 0.1g of carboxymethylcellulose, 0.2g of D-sorbitol and 0.4ml of absolute ethanol to the drug-coated carrier mixture obtained in step (1), and continue to stir and mix to obtain a semi-included drug;

[0040] (3) Add 0.05ml of polyethylene glycol 200 dropwise to the half-encapsulated drug in step (2) under stirring to increase the encapsulation efficiency. The complex was washed with water, and then dried in vacuum until the absolute ethanol volatilized completely to obtain a powdered acetylisovaleryl tartrate inclusion compound of tylosin. The measured encapsulation rate was 78.5%, and the drug loading was 25.8%;

[0041] (4) According to the drug loading, add starch to the acetylisovaleryl ...

Embodiment 2

[0043] A veterinary acetylisovaleryl tylosin tartrate premix, the preparation method of which is as follows:

[0044] (1) Mix 10g of acetylisovaleryl tylosin tartrate API with 20g of coating carrier complex (the coating carrier complex is hydroxypropyl-β-cyclodextrin and polyethylene glycol 6000 in a weight ratio of 2:1 The mixture) was stirred and mixed for 30 minutes to make a drug-coated carrier mixture;

[0045] (2) Add 0.3g of carboxymethylcellulose, 0.3g of D-sorbitol and 1.2ml of absolute ethanol to the drug-coated carrier mixture obtained in step (1), and continue to stir and mix to obtain a semi-included drug;

[0046] (3) Add 0.075ml of polyethylene glycol 200 dropwise to the semi-encapsulated drug in step (2) under stirring to increase the encapsulation efficiency. The compound was washed with water, and then dried in vacuum until the absolute ethanol volatilized completely, and the powdery acetylisovaleryl tylosin tartrate inclusion compound was obtained, the enca...

Embodiment 3

[0049] A veterinary acetylisovaleryl tylosin tartrate premix, the preparation method of which is as follows:

[0050] (1) Mix 10g of acetylisovaleryl tylosin tartrate API with 30g of coating carrier complex (the coating carrier complex is hydroxypropyl-β-cyclodextrin and polyethylene glycol 6000 in a weight ratio of 3:1 The mixture) was stirred and mixed for 30 minutes to make a drug-coated carrier mixture;

[0051] (2) Add 0.6 g of carboxymethyl cellulose, 1.6 g of D-sorbitol and 2.0 ml of absolute ethanol to the drug-coated carrier mixture obtained in step (1), and continue to stir and mix to obtain a semi-included drug;

[0052] (3) Add 0.2ml of polyethylene glycol 200 dropwise to the half-encapsulation drug in step (2) under stirring to increase the encapsulation efficiency. The complex was washed with water, and then dried in vacuum until the absolute ethanol volatilized completely, and the powdery acetylisovaleryl tartrate inclusion compound of tylosin was obtained. The...

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Abstract

The invention belongs to the technical field of antibiotic preparations for livestock, and in particular discloses an acetylisovaleryltylosin tartrate premixing agent for inhibiting porcine reproductive and respiratory syndrome virus for livestock and a preparation method thereof. The premixing agent consists of an acetylisovaleryltylosin tartrate inclusion compound and a matrix diluent, wherein the compound can effectively avoid illumination and temperature influences, so that the agent stability is improved, the agent is prevented from being influenced by the ingredients of a feed, the bitter taste of the agent is covered, and the palatability of livestock is improved; moreover, the agent has good liquidity and is easily mixed with the feed to administrate; and in addition, the acetylisovaleryltylosin tartrate inclusion compound can prolong drug release and agent acting time, so that the agent has long acting and slow releasing functions.

Description

technical field [0001] The invention relates to the technical field of veterinary antibiotic preparations, in particular to a veterinary acetylisovaleryl tylosin tartrate premix for inhibiting the replication of porcine PRRS virus and a preparation method thereof. Background technique [0002] Acetylisovaleryl Tylosin Tartrate, also known as Tyvalosin and Super Tylosin, is a new type of animal-specific antibiotic in the new generation of super macrolides. Acetylisovaleryl Tylosin tartrate is currently the antibiotic with the strongest activity against mycoplasma. Acetylisovaleryl Tylosin tartrate and its metabolite (3-AT) not only have a strong killing effect on pathogens such as Mycoplasma pneumoniae It can also activate macrophages in the body, increase the number of macrophages, enhance phagocytosis, promote the secretion of lysozyme, enhance the non-specific immune function of the body, and improve the influence of immunosuppressive factors of PRRS virus. Inhibit PRRS v...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K47/34A61K47/10A61K47/40A61P31/14
Inventor 张卫元陈翠兰刘洁黄文辉张翠平李硕张永丹魏彪肖飞丁文格唐万勇
Owner 武汉回盛生物科技股份有限公司
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