Nanometer compound ceftiofur suspension and preparation method thereof

A nano-suspension, ceftiofur technology, applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of low drug concentration, poor bioavailability, and increased dosage. Achieve the effects of simple preparation process, uniform particle size distribution, and scientific and reasonable formula

Inactive Publication Date: 2013-09-18
河南省针剂兽药工程技术研究中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Insoluble drugs are difficult to be absorbed by the body due to their low solubility in water, and their bioavailability is poor, so their clinical application is subject to a series of restrictions. , while livestock and poultry often lose their appetite and drinking water or waste it during the sick period, and the therapeutic effect cannot be achieved
2. In order to prepare stable liquid drugs for injection of sick livestock and poultry, it is often necessary to add a large amount of organic solvents or excipients, which is often an important reason for increasing adverse reactions
3. The drug concentration of insoluble drugs in the lesion is low, and the dosage is often increased in clinical practice to achieve the therapeutic effect, which has potential toxicity and drug resistance
[0005] Relevant reports on the compound ceftiofur nanosuspension and its preparation method have not yet been retrieved in the open literature

Method used

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  • Nanometer compound ceftiofur suspension and preparation method thereof
  • Nanometer compound ceftiofur suspension and preparation method thereof
  • Nanometer compound ceftiofur suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1, the preparation of compound ceftiofur hydrochloride nanosuspension

[0025] Prescription (1000mL):

[0026]

[0027]

[0028] Process: 1) Take soybean oil for injection, add ceftiofur hydrochloride and lecithin, and stir to obtain mixture A; 2) Take water for injection to dissolve astragalus polysaccharide, CMC-Na, sodium sulfite, and stir to obtain mixture B; 3) Mix mixture B Add to A, add ethanol, mix evenly; add soybean oil for injection to the full amount, mix evenly; 4) Grind the coarse suspension through a colloid mill for 5 minutes, then circulate 4 times under a pressure of 20Mpa through a homogenizer, and Homogenize by lower circulation for 15 times, and filter with a 0.22 μm microporous membrane to obtain the compound ceftiofur hydrochloride nanosuspension.

Embodiment 2

[0029] Embodiment 2, the preparation of compound ceftiofur hydrochloride nanosuspension

[0030] Prescription (1000mL):

[0031]

[0032] Process: 1) Take soybean oil for injection, add ceftiofur hydrochloride and Tween-80, and stir evenly to obtain mixture A; 2) Take water for injection to dissolve astragalus polysaccharide, sodium thiosulfate, and sodium benzoate, add carbomer and stir evenly to obtain Mixture B; 3) Add mixture B to A and mix evenly; add soybean oil for injection to the full amount and mix evenly; 4) Grind the coarse suspension through a colloid mill, and then circulate through a high-pressure homogenizer at a pressure of 30Mpa for 3 time, circulate homogeneously 12 times under 180Mpa pressure, and filter with 0.22 μm microporous membrane to obtain the compound ceftiofur nanosuspension.

Embodiment 3

[0033] Embodiment 3, the preparation of compound ceftiofur hydrochloride nanosuspension

[0034] Prescription (1000mL):

[0035]

[0036]

[0037] Process: 1) Take soybean oil for injection, add ceftiofur hydrochloride and Span-80, stir well to obtain mixture A; 2) take water for injection to dissolve astragalus polysaccharide, sodium metabisulfite, potassium sorbate, add gum arabic, stir well to obtain mixture B; 3) Add mixture B to A, add propylene glycol, and mix evenly; add soybean oil for injection to the full amount, and mix evenly; 4) Grind the coarse suspension through a colloid mill, and then pass it through a high-pressure homogenizer under a pressure of 10Mpa Circulate 5 times, circulate and homogenize 20 times under a pressure of 130Mpa, and filter with a 0.22 μm microporous membrane to obtain the compound ceftiofur nanosuspension.

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PUM

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Abstract

The invention discloses a nanometer compound ceftiofur suspension and a preparation method thereof, belonging to the technical field of antibiotic preparations for animals. The nanometer compound ceftiofur suspension comprises 1 to 30% of ceftiofur, 1 to 30% of astragalus polysaccharide, 0.1 to 40% of a surfactant, 0.1 to 30% of a wetting agent, 0.05 to 20% of a suspending agent, 0.1 to 10% of an anti-oxidant and 0.1 to 10% of an antiseptic, with the balance being soybean oil for injection. The nanometer compound ceftiofur suspension provided by the invention has the advantages of a scientific and reasonable formula, safety, high efficiency, a small particle size, uniform particle size distribution, simple preparation process, good stability and suitability for industrial mass production.

Description

technical field [0001] The invention belongs to the technical field of veterinary antibiotic preparations, and relates to a compound ceftiofur nanosuspension, in particular to a preparation method of the compound ceftiofur nanosuspension. Background technique [0002] Ceftiofur (Ceftiofur), also known as Saidefu, is the first third-generation cephalosporin antibiotic for animals. It has a broad antibacterial spectrum and strong antibacterial activity. It has been approved by the FDA for the treatment of respiratory infections in cattle since 1988. Because of its excellent antibacterial activity and in vivo pharmacokinetic process, as well as the advantages of less drug residue and less toxic and side effects, it has been widely concerned in veterinary clinics at home and abroad. Its most unique feature is that the content of the drug in the infected tissue is 2 to 4 times higher than that in the non-infected tissue, and it works in a targeted and concentrated distribution an...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K9/10A61P31/04A61P37/04A61K31/546
Inventor 饶刚李逐波廖丹丹徐泽民徐高贤
Owner 河南省针剂兽药工程技术研究中心
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