Nanometer compound ceftiofur suspension and preparation method thereof

A nano-suspension, ceftiofur technology, applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of low drug concentration, poor bioavailability, and increased dosage. Achieve the effects of simple preparation process, uniform particle size distribution, and scientific and reasonable formula
CN103301147AInactive Publication Date: 2013-09-18河南省针剂兽药工程技术研究中心
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
河南省针剂兽药工程技术研究中心
Publication Date
2013-09-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a nanometer compound ceftiofur suspension and a preparation method thereof, belonging to the technical field of antibiotic preparations for animals. The nanometer compound ceftiofur suspension comprises 1 to 30% of ceftiofur, 1 to 30% of astragalus polysaccharide, 0.1 to 40% of a surfactant, 0.1 to 30% of a wetting agent, 0.05 to 20% of a suspending agent, 0.1 to 10% of an anti-oxidant and 0.1 to 10% of an antiseptic, with the balance being soybean oil for injection. The nanometer compound ceftiofur suspension provided by the invention has the advantages of a scientific and reasonable formula, safety, high efficiency, a small particle size, uniform particle size distribution, simple preparation process, good stability and suitability for industrial mass production.
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Description

technical field

[0001] The invention belongs to the technical field of veterinary antibiotic preparations, and relates to a compound ceftiofur nanosuspension, in particular to a preparation method of the compound ceftiofur nanosuspension. Background technique

[0002] Ceftiofur (Ceftiofur), also known as Saidefu, is the first third-generation cephalosporin antibiotic for animals. It has a broad antibacterial spectrum and strong antibacterial activity. It has been approved by the FDA for the treatment of respiratory infections in cattle since 1988. Because of its excellent antibacterial activity and in vivo pharmacokinetic process, as well as the advantages of less drug residue and less toxic and side effects, it has been widely concerned in veterinary clinics at home and abroad. Its most unique feature is that the content of the drug in the infected tissue is 2 to 4 times higher than that in the non-infected tissue, and it works in a targeted and concentrated distribution an...

Claims

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