Quickly UV (ultraviolet) curable and water soluble chitosan derivative and synthesis method thereof

A technology of chitosan derivatives and synthesis methods, applied in the field of biopolymer materials and their synthesis, can solve problems such as long UV irradiation time, and achieve the effect of short irradiation time

Inactive Publication Date: 2013-10-02
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problem that the synthesis of existing UV-curable and water-soluble chitosan derivatives requires multi-step chemical reactions. The synthesis process needs to add an EDC/NHS catalyst that activates the

Method used

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  • Quickly UV (ultraviolet) curable and water soluble chitosan derivative and synthesis method thereof
  • Quickly UV (ultraviolet) curable and water soluble chitosan derivative and synthesis method thereof
  • Quickly UV (ultraviolet) curable and water soluble chitosan derivative and synthesis method thereof

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specific Embodiment approach 1

[0018] Specific embodiment one: a kind of fast UV curable and water-soluble chitosan derivative of the present embodiment is N-methacryloyl chitosan, and its structural formula is:

[0019]

[0020] Wherein, m is the molar percentage of chitosan participating in the acylation reaction, and n is the molar percentage of chitosan not participating in the acylation reaction.

specific Embodiment approach 2

[0021] Specific embodiment two: a kind of fast UV curing of the present embodiment and the synthetic method of the water-soluble chitosan derivative are to carry out according to the following steps:

[0022] 1. Dissolve 1g of chitosan in acetic acid solution, prepare a chitosan acetic acid solution with a mass volume concentration of 0.4% to 2.8% at room temperature, and slowly add 0.3 to 3.5g of chitosan to the prepared chitosan acetic acid solution. Methacrylic anhydride, control the reaction temperature at 20-65°C, react for 3-24 hours, and obtain a mixed solution;

[0023] 2. Use ammonia solution with a molar concentration of 0.46-0.95mol / L or NaHCO with a molar concentration of 0.45-0.83mol / L 3 The pH value of the mixed solution obtained in the aqueous solution adjustment step 1 is 6.3-8.2, dialyze the adjusted mixed solution in a deionized water environment at a temperature of 30-55°C for 3-7 days, and replace it every 12-24 hours Deionized water, after dialysis, the s...

specific Embodiment approach 3

[0028] Specific embodiment three: the difference between this embodiment and specific embodiment two is: in step one, the chitosan acetic acid solution with a mass volume concentration of 1.0% is prepared. Others are the same as in the second embodiment.

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Abstract

The invention provides a quickly UV (ultraviolet) curable and water soluble chitosan derivative and a synthesis method thereof, relates to a biological high molecular material and a synthesis method thereof, and aims to solve the technical problems that the existing UV curable chitosan derivative preparation method is complex, the addition of a catalyst is required in the preparation process and the prepared UV curable chitosan derivative requires long irradiation time. The quickly UV curable and water soluble chitosan derivative provided by the invention is an N-methylacryloyl chitosan of which the structural formula is shown in the specification, wherein m is the mol percent of chitosan participating in the acylation reaction, and n is the mol percent of chitosan not participating in the acylation reaction. The synthesis method provided by the invention comprises the following steps: 1, preparing a chitosan acetic acid solution; 2, preparing a mixed solution; and 3, preparing the quickly UV curable and water soluble chitosan derivative. The invention is applied to the field of synthesis and modification of biological high molecular materials.

Description

technical field [0001] The invention relates to a biopolymer material and a synthesis method thereof. Background technique [0002] Chitosan is the only weakly alkaline natural polysaccharide with amino groups in nature. Due to its good biocompatibility and biodegradability, it can be used in the fields of drug release, tissue engineering and wound dressing. However, the strong hydrogen bonds between chitosan molecules and molecules make it insoluble in water, physiological saline or simulated body fluids and other pH-neutral aqueous media, and it cannot be cured by UV. Since chitosan is rich in reactive groups (amino and hydroxyl groups), chemical modification of these reactive groups can endow chitosan with water-soluble and photocurable properties, which will certainly broaden chitosan's Tissue engineering (such as injectable chitosan hydrogel system based on photocuring), drug release (encapsulation or loading of biologically active substances, such as drugs, proteins a...

Claims

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Application Information

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IPC IPC(8): C08B37/08
Inventor 李保强王磊耿晓梅贾德昌周玉
Owner HARBIN INST OF TECH
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