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Cinnamomum longepaniculatum leaf volatile oil emulsion in water

A technology of oil-water emulsion and camphor leaves, which is applied in the fields of antifungal agents, emulsion delivery, pharmaceutical formulations, etc., can solve the problems that there are no technical tips for the emulsification of camphor leaf volatile oil in the literature, and can not be found, so as to achieve good product stability , low production cost and simple preparation process

Active Publication Date: 2013-11-20
YIBIN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during our research, we did not find any reference materials, and there was no literature disclosing the technical tips for the emulsification of camphor leaf volatile oil

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Raw material formula (by weight percentage): camphor leaf volatile oil 20kg, emulsifier (Span-80 and Tween-80) 5kg, emulsifier HLB value adjusted to 13.0, antifreeze agent (ethanol) 0.5kg, water 74.5kg.

[0017] Preparation method: According to the above formula ratio, first add emulsifier Span-80 and Tween-80 into a high-speed homogenizer, stir at a low speed and mix well, then add camphor leaf volatile oil and continue stirring until the volatile oil is fully dissolved and mixed evenly to obtain the oil phase Dissolve the antifreeze ethanol in water, stir and mix to obtain the water phase; then gradually add the water phase to the oil phase under high-speed stirring, the speed is controlled at 10,000 rpm, and fully homogeneously form a good volatile oil water of camphor leaves emulsion.

Embodiment 2

[0019] Raw material formula (percentage by weight): 20kg of camphor leaf volatile oil, 4kg of emulsifier (Span-20 and Tween-80 mixture), the HLB value of emulsifier adjusted to 12.0, co-emulsifier (n-hexanol) 2kg, antifreeze (B Glycol) 2kg, water 72kg.

[0020] Preparation method: According to the above formula ratio, first add emulsifier Span-20, Tween-80 and co-emulsifier n-hexanol into a high-speed homogenizer, stir at a low speed and mix well, then add camphor leaf volatile oil and continue stirring until the volatile oil is fully dissolved and mixed Evenly, the oil phase is obtained; dissolve the antifreeze ethylene glycol in water, stir and mix to obtain the water phase; then gradually add the water phase to the oil phase under high-speed stirring, the speed is controlled at 4000 rpm, fully homogeneous into a good camphor leaf volatile oil-water emulsion.

Embodiment 3

[0022] Raw material formula (percentage by weight): 4kg camphor leaf volatile oil, emulsifier (Span-80 and Tween-20) 8kg, emulsifier HLB value adjusted to 14.0, co-emulsifier (n-butanol) 0.2kg, antifreeze ( Propylene glycol) 4kg, water 83.8kg.

[0023] Preparation method: According to the above formula ratio, first add emulsifier Span-80, Tween-20 and co-emulsifier n-hexanol into a high-speed homogenizer, stir at a low speed, then add camphor leaf volatile oil and continue stirring until the volatile oil is fully dissolved and mixed Dissolve the antifreeze agent propylene glycol in water, stir and mix to obtain the water phase; then gradually add the water phase to the oil phase under high-speed stirring, the speed is controlled at 8000 rpm, fully homogenized into a good volatile oil-water emulsion of camphor leaves.

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PUM

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Abstract

The invention relates to a Cinnamomum longepaniculatum leaf volatile oil emulsion in water, which his characterized by containing 1-35 parts by weight of Cinnamomum longepaniculatum leaf volatile oil, 1-10 parts by weight of emulsifying agent, 0.2-4 parts by weight of anti-freezing agent and 46-97.6 parts by weight of water, wherein the hydrophilic lipophilic balance value of the emulsifying agent is 10.0-16.0. The preparation method of the emulsion in water comprises the following steps of: firstly mixing the emulsifying agent and the co-emulsifier and stirring evenly, then, adding the Cinnamomum longepaniculatum leaf volatile oil and mixing evenly to prepare oil phase; mixing the anti-freezing agent and the water evenly to prepare aqueous phase; and then, gradually adding the aqueous phase into the oil phase while stirring at a high speed, and homogenizing the mixture to form a good Cinnamomum longepaniculatum leaf volatile oil emulsion in water. The Cinnamomum longepaniculatum leaf volatile oil emulsion in water provided by the invention has the advantages of low toxic and side effects, excellent clinical effect, high product stability, low production cost, simple preparation technology, strong operability, and so on, and can be used for treating animal dermatomycosis in veterinary clinic.

Description

technical field [0001] The invention relates to a medicament for resisting fungal skin diseases, which is especially suitable for treating fungal skin diseases of animals. Background technique [0002] Dermatomycosis, namely animal skin mycosis, commonly known as ringworm, alopecia trichophyton, grape rash, etc., is a zoonotic skin mycosis caused by a variety of skin filamentous bacteria, which is highly contagious. There are more than 20 known skin fungi, which can be divided into three genera: Trichophyton, Microsporum, and Epidermophyton. Animals infected with skin fungus may lose their appetite, become thin, and listless in mild cases. In severe cases, they may suffer from malnutrition and slow growth, and may eventually die of collapse, reducing production performance and product quality, and causing serious economic losses to the breeding industry. [0003] At present, there are no special antifungal veterinary drugs in veterinary clinics in my country, and the antifu...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61K9/107A61P31/10A61P17/00A61K127/00
Inventor 魏琴殷中琼杜永华贾仁勇范静周黎军徐州
Owner YIBIN UNIV
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