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Preparation method and device for multilayered embedded particles

A particle and equipment technology, which is applied in the field of equipment for preparing the particle, can solve the problems of uneven particle distribution, low embedding rate of core materials, unstable active ingredients, etc. The effect of solvent residue

Active Publication Date: 2013-11-27
INNOBIO CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The microcapsule membrane wall formed in this way can only embed the core material in a single layer, and its product has some defects; the temperature in the drying process is high, which easily causes the loss of active ingredients; the embedding rate of the wall material to the core material is not high, and the active ingredients are not Stability, poor product fluidity, uneven particle distribution, poor mechanical strength, etc.

Method used

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  • Preparation method and device for multilayered embedded particles

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preparation example Construction

[0041] A method for preparing multilayer embedded microparticles, comprising the steps of:

[0042] a) a step of dispersing the active ingredient in a protective colloid solution to form an active ingredient suspension;

[0043] b) a step of forming the suspension in step a) into droplets with a particle size distribution of 100-1000 μm;

[0044] c) attaching a second layer of embedding material to the surface of the droplet in step b), and obtaining bead-shaped particles after solidification; and

[0045] d) Further drying the bead-like particles, the step of embedding microparticles in multiple layers.

[0046] Attached below figure 1 The multilayer embedding particle device shown in exemplifies the preparation method of the above-mentioned multilayer embedding particle.

[0047] The multi-layer embedded particle device ( figure 1 ) includes a forming tower 1, an atomizer 2, a silo 3, a conveying device 4 and a drying device 5, wherein the atomizer 2 is arranged in the f...

Embodiment 1

[0052] Put 110g of sodium caseinate and 890g of sucrose in 2000ml of water, heat up to 60°C, stir until they are evenly mixed and dissolved to obtain a protective colloid solution. Then slowly add 1000g fish oil (EPA / DHA: 18 / 12) into the protective colloid solution, stir evenly, and homogenize the obtained suspension twice under 40MPa pressure to obtain an emulsion; send the emulsion into centrifugal atomization At the same time, the edible cornstarch (powder) in the silo is sent to the atomization tower by the wind, and the atomized droplets are wrapped; the particles of the wrapped cornstarch are collected, and the remaining starch is screened out to obtain bead-shaped granules. The particle size is 40 mesh to 120 mesh, and the particles are further dried in a fluidized fluidized bed until the water content is less than 5.0%, and 1890g of fish oil particles are obtained. The mass percentage of Omega3 in the particles is 12%, and the bulk density of the particles is 0.63g / ml...

Embodiment 2

[0054] Put 400g of gum arabic and 390g of corn syrup in 980ml of water, heat up to 55°C, stir until evenly mixed and dissolved to obtain a protective colloid solution; mix 50g of mixed tocopherols, 160g of lutein crystals (mass percentage of lutein 80%, from Dalian Yinuo Biological Co., Ltd. ) slowly added to the protective colloid solution. And through emulsification homogenization 2 times, homogenization pressure 60Mpa. The above-mentioned emulsion is sent to the centrifugal atomizer for atomization, and at the same time, food-grade modified starch (the amount of silicon dioxide added is 5%) is sent into the atomization tower by the air, and the atomized droplets are wrapped. Collect the wet granules wrapped with modified starch, then sieve the remaining starch to obtain bead-shaped granules with a particle size of 20 mesh to 140 mesh, and further dry the granules in a vibrating fluidized bed until the water content is 3.0%, to obtain 935g leaves Lutein microparticles (10...

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Abstract

The invention provides a preparation method and device for multilayered embedded particles. The preparation method comprises the following steps of: dispersing active components into a protective colloidal solution to form an active component mixed suspension solution; processing the mixed suspension solution into liquid drops with the grain diameter in a range of 100-1000 microns; enabling second-layer embedding materials to be attached to the surfaces of the liquid drops and curing to obtain bead-shaped grains; and further drying the bead-shaped grains to obtain the multilayered embedded particles. The preparation method provided by the invention is simple in device and easy to operate. The multilayered embedded particles provided by the invention have high stability, narrow grain diameter distribution, good flowability and high mechanical strength, and can be widely applied to fields of tablets, hard capsules, diet supplementing foods, health-care foods, medicines and the like.

Description

technical field [0001] The invention relates to a preparation method and equipment for multi-layer embedded particles (beadlets), more specifically, the invention provides a multi-layer embedded active ingredient to obtain high stability, narrow particle size distribution, fluidity A method for good, mechanically robust microencapsulated microparticles and an apparatus for preparing the microparticles. Background technique [0002] Microcapsule is a technology that embeds and seals solid, liquid or gaseous substances in a microcapsule to become a solid particle product. In this way, the wrapped components can be protected and isolated from the unsuitable environment of the outside world, so as to maintain the original color, fragrance, performance and biological activity to the maximum extent, and prevent the destruction and loss of nutrients. Microcapsule technology is essentially a packaging technology, and its effect is closely related to the "packaging material" wall ma...

Claims

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Application Information

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IPC IPC(8): A23P1/04A23P10/30
Inventor 吴文忠陈剑彬王建华吕忠武陈碧聪
Owner INNOBIO CORP LTD
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