Method for preparing nano drug-carrying capsule-loaded alginate fibers
A technology of nano-drug loading and seaweed fiber, which is applied in the direction of capsule delivery, microcapsules, nanocapsules, etc., can solve the problems of single drug properties and low effective load, so as to expand the application field, reduce wound infection, and reduce the cost of drugs. churn effect
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Embodiment 1
[0019] (1) Weigh 10 g of sodium alginate and add it to 750 mL of deionized water, stir in a water bath at 50 °C for 30 min to obtain a uniform sodium alginate solution; add 0.02 mol / L of Ca(OH) dropwise successively 2 solution and 0.03 mol / L NaHCO 3 Each solution was 200 mL, and stirred for 1 h in a constant temperature water bath at 50 °C; 200 mL of 200 μg / mL vancomycin hydrochloride aqueous solution was added, and stirred for 2 h in a constant temperature water bath at 50 °C; the mixed solution was placed in an ice water bath, and stood for 24 h , centrifuged at 12000 rpm and washed three times with water, and finally freeze-dried to obtain calcium alginate nanocapsules loaded with vancomycin hydrochloride, with a drug loading capacity of 23%.
[0020] (2) Weigh 10 g of sodium alginate and add it to 275 mL of deionized water, stir and dissolve fully to obtain a sodium alginate solution with a mass concentration of 3.5 %; weigh 0.1 g of calcium alginate nanocapsules loaded wi...
Embodiment 2
[0022] (1) Weigh 10 g of sodium alginate and add it to 750 mL of deionized water, stir in a water bath at 50 °C for 30 min to obtain a uniform sodium alginate solution; add 0.02 mol / L of Ca(OH) dropwise successively 2 solution and 0.03 mol / L NaHCO 3 Each solution was 200 mL, and stirred for 1 h in a constant temperature water bath at 50 °C; 200 mL of 200 μg / mL ibuprofen solution was added, and stirred for 2 h in a constant temperature water bath at 50 °C to disperse evenly; the mixed solution was placed in an ice water bath, and stood for 24 h, centrifuged at 12000 rpm and washed three times with water, and finally freeze-dried to obtain calcium alginate nanocapsules loaded with ibuprofen, with a drug loading capacity of 36%.
[0023] (2) Weigh 10 g of sodium alginate and add it to 275 mL of deionized water, fully stir and dissolve to obtain a sodium alginate solution with a mass concentration of 3.5 %; weigh 1.5 g of calcium alginate nanocapsules loaded with ibuprofen, add i...
Embodiment 3
[0025] (1) Weigh 10 g of sodium alginate and add it to 750 mL of deionized water, stir in a water bath at 50 °C for 30 min to obtain a uniform sodium alginate solution; add 0.02 mol / L of Ca(OH) dropwise successively 2 solution and 0.03 mol / L NaHCO 3 Each solution was 200 mL, and stirred in a constant temperature water bath at 50 °C for 1 h; adding 100 mL of 200 μg / mL ibuprofen solution, stirred in a constant temperature water bath at 50 °C for 1 h, and then added 100 mL of 200 μg / mL vancomycin hydrochloride , and continue stirring for 1 h; the mixture was placed in an ice-water bath, allowed to stand for 24 h, centrifuged at 12,000 rpm and washed three times with water, and finally freeze-dried to obtain calcium alginate nanocapsules loaded with ibuprofen and vancomycin hydrochloride at the same time. The ibuprofen loading was 31%, and the vancomycin hydrochloride loading was 18%.
[0026] (2) Weigh 10.0 g of sodium alginate and add it to 275 mL of deionized water, stir and d...
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