Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of vitamin C chewable tablet and preparation method thereof

A technology of chewable tablets and vitamins, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of complicated procedures, adding more auxiliary materials, and large calorie value of chewable tablets, etc., to achieve Improved fluidity and tablet quality, reduced irritating sour taste, and better product quality

Active Publication Date: 2016-03-02
SHANDONG TIANLI PHARMA
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of this patent are: the addition of mannitol, dextrin, sucrose, and pregelatinized starch that have not been milled and granulated will affect the fluidity of the mixture, which is not conducive to continuous production, and the addition of too many powder components will affect the taste of chewable tablets ; The proportion of pregelatinized starch, sucrose, and dextrin is relatively large, which makes the calorie value of chewable tablets too large; aspartame can be replaced by adding sugar alcohols, adding too many excipients, high risk of product quality, and complicated procedures

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of vitamin C chewable tablet and preparation method thereof
  • A kind of vitamin C chewable tablet and preparation method thereof
  • A kind of vitamin C chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045]The formula of the chewable tablet is as follows: direct compression grade Vc97% granules, 18.36%; direct compression grade mannitol 100% granules, 44.9%; fructose powder, 10%; maltodextrin, 7.42%; microcrystalline cellulose 8.51%; silicon dioxide 4.45%; Eudragit 1.88%; stevia, 1.5%; magnesium stearate, 1.1%; lemon flavor 1.88%.

[0046] The preparation method is as follows:

[0047] 1. Preparation of direct pressure grade Vc97% granules:

[0048] ① Grinding: Vc crystal particles are pulverized by a small high-speed pulverizer for 6 seconds to 150-250 mesh; Vc-Ca crystal particles are pulverized by a small high-speed pulverizer for 5 seconds to 150-250 mesh.

[0049] ② Mixing: Add 500g of Vc powder into the V-shaped mixer, add 500g of Vc-Ca, and mix for 3 minutes.

[0050] ③Preparation of binder solution (also called pulping, the same below): Weigh 30g of HPMC with a viscosity of 3mpa.s, dissolve it in 400mL of purified water at 45°C for pulping, and prepare a binder s...

Embodiment 2

[0063] The formula of the chewable tablet is as follows: direct compression grade Vc97% granules, 18.36%; direct compression grade mannitol 100% granules, 39.15%; fructose powder, 13%; maltodextrin, 5.94%; microcrystalline cellulose 12.5%; silicon dioxide 6.5%; Eudragit, 1.59%; stevia, 0.74%; magnesium stearate, 1.48%; blueberry flavor, 0.74%.

[0064] The preparation method is as follows:

[0065] 1. Preparation of direct pressure grade Vc97% granules:

[0066] ① Grinding: Vc crystal particles are pulverized by a small high-speed pulverizer for 2 seconds to 150-250 mesh; Vc-Ca is pulverized by a small high-speed pulverizer for 6 seconds to 150-250 mesh.

[0067] ② Mixing: Add 500g of Vc powder into the V-type mixer, add 250g of Vc-Ca (vitamin calcium), and mix for 3 minutes.

[0068] ③Slurry mixing: Weigh 15g of HPMC and 3015g of PVPK with a viscosity of 3mpa.s, dissolve them in 250mL of purified water at 50°C for slurry mixing, and obtain a binder solution.

[0069] ④ Mul...

Embodiment 3

[0081] Chewable tablet formula: direct pressure grade Vc97% granules, 18.36%; direct pressure grade mannitol 100% granules, 43.53%; microcrystalline cellulose 19.30%; fructose, 7.5%; silicon dioxide 7.33%; stevia, 0.5% ; Eudragit, 1.0%; Magnesium Stearate, 1.48%; Blueberry Flavor 1.0%.

[0082] The preparation method is as follows:

[0083] 1. Preparation of direct pressure grade Vc97% granules:

[0084] ① Grinding: Vc crystal particles are pulverized by a small high-speed pulverizer for 5 seconds to 150-250 mesh; Vc-Ca is pulverized by a small high-speed pulverizer for 2 seconds to 150-250 mesh.

[0085] ② Mixing: Add 500g of Vc powder into the V-shaped mixer, add 1000g of Vc-Ca, and mix for 10 minutes.

[0086] ③Sizing: Weigh 20g of HPMC with a viscosity of 3mpa.s and 10g of pregelatinized starch, dissolve them in 450mL of purified water at 45°C for slurrying, and obtain a binder solution.

[0087] ④ Multifunctional fluidized bed dry granulation: Weigh 970g of the mixed m...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
thicknessaaaaaaaaaa
bulk densityaaaaaaaaaa
Login to View More

Abstract

The present invention disclosed a vitamin C chew tablet, including the following quality percentage content: 18.36%of the direct pressure VC particles, 48.15 ~ 56.4%of sweet flavor agents, 4.45 to 10%of silicon dioxide, Yutcic 1.0 ~ 1.88%, Microcrystalline cellulose 8.51 ~ 19.3%, malt paste 0 ~ 7.42%, fragrance 0.6 to 1.0%, and 1.1 to 1.75%of magnesium magnesium.The present invention also disclosed its preparation method.The invention uses VC and VC salt as an effective ingredient. The recipe is added to Yutcic, which increases product stability and reduces bitterness.The method of the present invention increases the liquidity of the material. Through the improvement of the formula and preparation method, the performance of the product's appearance, taste, hardness, fragmented, and disintegration time has been improved.

Description

technical field [0001] The invention relates to a vitamin C tablet and a preparation method thereof, in particular to a vitamin C chewable tablet and a preparation method thereof, and belongs to the technical field of vitamin C deep processing. Background technique [0002] Vitamin C, also known as L-ascorbic acid, can participate in various redox reactions and hydroxylation reactions in the body. Blood disease, enhance the body's resistance. Green plants can synthesize vitamin C by themselves. However, humans and many animals cannot synthesize vitamin C by themselves due to the lack of gurolactone oxidase in their livers, and must ingest it from the outside. At present, vitamin C has been widely used in the fields of medicine, food, health care products and cosmetics. And with the development of its use and the improvement of people's material and cultural living standards, the demand for vitamin C is also increasing. [0003] Patent 200910074601.6 discloses a method for...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/375A61K47/10A61K47/34A61P3/02A61P7/04
Inventor 刘敏王乔隆郑秀宁李慧君付吉明
Owner SHANDONG TIANLI PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com