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Vitamin C chewable tablet and preparation method thereof

A technology for vitamins and chewable tablets, which is applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Improved fluidity and tablet quality, reduced irritating sourness, and improved product quality

Active Publication Date: 2013-12-25
SHANDONG TIANLI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of this patent are: the addition of mannitol, dextrin, sucrose, and pregelatinized starch that have not been milled and granulated will affect the fluidity of the mixture, which is not conducive to continuous production, and the addition of too many powder components will affect the taste of chewable tablets ; The proportion of pregelatinized starch, sucrose, and dextrin is relatively large, which makes the calorie value of chewable tablets too large; aspartame can be replaced by adding sugar alcohols, adding too many excipients, high risk of product quality, and complicated procedures

Method used

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  • Vitamin C chewable tablet and preparation method thereof
  • Vitamin C chewable tablet and preparation method thereof
  • Vitamin C chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045]The formula of the chewable tablet is as follows: direct compression grade Vc97% granules, 18.36%; direct compression grade mannitol 100% granules, 44.9%; fructose powder, 10%; maltodextrin, 7.42%; microcrystalline cellulose 8.51%; silicon dioxide 4.45%; Eudragit 1.88%; stevia, 1.5%; magnesium stearate, 1.1%; lemon flavor 1.88%.

[0046] The preparation method is as follows:

[0047] 1. Preparation of direct pressure grade Vc97% granules:

[0048] ① Grinding: Vc crystal particles are pulverized by a small high-speed pulverizer for 6 seconds to 150-250 mesh; Vc-Ca crystal particles are pulverized by a small high-speed pulverizer for 5 seconds to 150-250 mesh.

[0049] ② Mixing: Add 500g of Vc powder into the V-shaped mixer, add 500g of Vc-Ca, and mix for 3 minutes.

[0050] ③Preparation of binder solution (also called pulping, the same below): Weigh 30g of HPMC with a viscosity of 3mpa.s, dissolve it in 400mL of purified water at 45°C for pulping, and prepare a binder s...

Embodiment 2

[0063] The formula of the chewable tablet is as follows: direct compression grade Vc97% granules, 18.36%; direct compression grade mannitol 100% granules, 39.15%; fructose powder, 13%; maltodextrin, 5.94%; microcrystalline cellulose 12.5%; silicon dioxide 6.5%; Eudragit, 1.59%; stevia, 0.74%; magnesium stearate, 1.48%; blueberry flavor, 0.74%.

[0064] The preparation method is as follows:

[0065] 1. Preparation of direct pressure grade Vc97% granules:

[0066] ① Grinding: Vc crystal particles are pulverized by a small high-speed pulverizer for 2 seconds to 150-250 mesh; Vc-Ca is pulverized by a small high-speed pulverizer for 6 seconds to 150-250 mesh.

[0067] ② Mixing: Add 500g of Vc powder into the V-type mixer, add 250g of Vc-Ca (vitamin calcium), and mix for 3 minutes.

[0068] ③Slurry mixing: Weigh 15g of HPMC and 3015g of PVPK with a viscosity of 3mpa.s, dissolve them in 250mL of purified water at 50°C for slurry mixing, and obtain a binder solution.

[0069] ④ Mul...

Embodiment 3

[0081] Chewable tablet formula: direct pressure grade Vc97% granules, 18.36%; direct pressure grade mannitol 100% granules, 43.53%; microcrystalline cellulose 19.30%; fructose, 7.5%; silicon dioxide 7.33%; stevia, 0.5% ; Eudragit, 1.0%; Magnesium Stearate, 1.48%; Blueberry Flavor 1.0%.

[0082] The preparation method is as follows:

[0083] 1. Preparation of direct pressure grade Vc97% granules:

[0084] ① Grinding: Vc crystal particles are pulverized by a small high-speed pulverizer for 5 seconds to 150-250 mesh; Vc-Ca is pulverized by a small high-speed pulverizer for 2 seconds to 150-250 mesh.

[0085] ② Mixing: Add 500g of Vc powder into the V-shaped mixer, add 1000g of Vc-Ca, and mix for 10 minutes.

[0086] ③Sizing: Weigh 20g of HPMC with a viscosity of 3mpa.s and 10g of pregelatinized starch, dissolve them in 450mL of purified water at 45°C for slurrying, and obtain a binder solution.

[0087] ④ Multifunctional fluidized bed dry granulation: Weigh 970g of the mixed m...

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Abstract

The invention discloses a vitamin C chewable tablet, comprising the following components in mass percent: 18.36% of direct pressure level Vc particles, 48.15-56.4% of sweetener, 4.45-10% of silica, 1.0-1.88% of eudragit, 8.51-19.3% of microcrystalline cellulose, 0-7.42% of maltodextrin, 0.6-1.0% of essence and 1.1-1.75% of magnesium stearate. The invention further discloses a preparation method of the vitamin C chewable tablet. According to the vitamin C chewable tablet disclosed by the invention, Vc and Vc salt are used as active ingredients, and the eudragit is added into the formula to increase the product stability and reduce the bitter taste. According to the method disclosed by the invention, the fluidity of materials is increased, and the formula and the preparation method are improved to enhance such properties of the product as appearance, taste, hardness, brittleness, disintegrating time, etc.

Description

technical field [0001] The invention relates to a vitamin C tablet and a preparation method thereof, in particular to a vitamin C chewable tablet and a preparation method thereof, and belongs to the technical field of vitamin C deep processing. Background technique [0002] Vitamin C, also known as L-ascorbic acid, can participate in various redox reactions and hydroxylation reactions in the body. Blood disease, enhance the body's resistance. Green plants can synthesize vitamin C by themselves. However, humans and many animals cannot synthesize vitamin C by themselves due to the lack of gurolactone oxidase in their livers, and must ingest it from the outside. At present, vitamin C has been widely used in the fields of medicine, food, health care products and cosmetics. And with the development of its use and the improvement of people's material and cultural living standards, the demand for vitamin C is also increasing. [0003] Patent 200910074601.6 discloses a method for...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/375A61K47/10A61K47/34A61P3/02A61P7/04
Inventor 刘敏王乔隆郑秀宁李慧君付吉明
Owner SHANDONG TIANLI PHARMA
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