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Multi-trace-element injection (II) medicine composition and preparation method thereof

A technology of trace elements and compositions, which is applied in the field of various trace element injections (II) pharmaceutical compositions and their preparations, can solve the problems of discoloration, turbidity, deepening, etc., achieve good stability, simple preparation method, and improve safety sexual effect

Active Publication Date: 2014-01-01
LIAONING HAISCO PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It was reported in an article (Zhao Weili, Analysis of Incompatibility of Various Trace Element Injections and Drugs, Journal of Practical Medicine, 2012, 29(8):711-712) that the combination of various trace element injections with cefoperazone sodium, ceftriaxone sodium, and fleroxacin , furubicillin sodium, cimetidine, pantoprazole sodium, vitamin B 6 , Compound amino acids, vitamin C and other injections are compatible with flocculent precipitation, turbidity, discoloration and deepening, etc., so there are incompatibility

Method used

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  • Multi-trace-element injection (II) medicine composition and preparation method thereof
  • Multi-trace-element injection (II) medicine composition and preparation method thereof
  • Multi-trace-element injection (II) medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1 Preparation of various trace element injections (II) pharmaceutical composition

[0049] prescription:

[0050]

[0051]

[0052] The preparation method is prepared according to the following steps:

[0053] (1) Prepare citrate-Na at pH 2.4 with water for injection 2 HPO 4 Buffered solution, in which citric acid (C 6 h 8 o 7 ·H 2 O) The dosage is 19.698g, Na 2 HPO 4 The dosage is 1.7608g;

[0054] (2) Take the prescribed amount of chromium chloride, copper chloride, manganese chloride, zinc chloride, and sodium fluoride to dissolve the solution with an appropriate amount of buffer;

[0055] (3) Take the prescribed amount of sorbitol, taurine, and glycine, stir and dissolve the solution with an appropriate amount of buffer, and then add it to the solution prepared in step (2) and mix well;

[0056] (4) Add 0.02% activated carbon (W / V) of the volume of the solution obtained in step (3), stir and adsorb for 15 minutes, and circulate decarboniza...

Embodiment 2

[0059] Embodiment 2 Preparation of various trace element injections (II) pharmaceutical composition

[0060] prescription:

[0061]

[0062]

[0063] The preparation method is prepared according to the following steps:

[0064] (1) Prepare citrate-Na at pH 2.2 with water for injection 2 HPO 4 Buffered solution, in which citric acid (C 6 h 8 o 7 ·H 2 O) The dosage is 20.58g, Na 2 HPO 4 The dosage is 0.568g;

[0065] (2) Take the prescribed amount of chromium chloride, copper chloride, manganese chloride, zinc chloride, and sodium fluoride to dissolve the solution with an appropriate amount of buffer;

[0066] (3) Take the prescribed amount of sorbitol, taurine, and glycine, stir and dissolve the solution with an appropriate amount of buffer, and then add it to the solution prepared in step (2) and mix well;

[0067] (4) Add 0.02% activated carbon (W / V) of the volume of the solution obtained in step (3), stir and adsorb for 10 minutes, and circulate decarbonizati...

Embodiment 3

[0070] Embodiment 3 Preparation of various trace element injections (II) pharmaceutical composition

[0071] prescription:

[0072]

[0073]

[0074] The preparation method is prepared according to the following steps:

[0075] (1) Prepare citrate-Na at pH 2.0 with water for injection 2 HPO 4 Buffered solution, in which citric acid (C 6 h 8 o 7 ·H 2 O) The dosage is 20.895g, Na 2 HPO 4 The dosage is 0.142g;

[0076] (2) Take the prescribed amount of chromium chloride, copper chloride, manganese chloride, zinc chloride, and sodium fluoride to dissolve the solution with an appropriate amount of buffer;

[0077] (3) Take the prescribed amount of sorbitol, taurine, and glycine, stir and dissolve the solution with an appropriate amount of buffer, and then add it to the solution prepared in step (2) and mix well;

[0078] (4) Add 0.02% activated carbon (W / V) of the volume of the solution obtained in step (3), stir and adsorb for 20 minutes, and circulate decarbonizat...

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PUM

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Abstract

The invention relates to a multi-trace-element injection (II) medicine composition capable of improving compatible stability and a preparation method thereof. By virtue of the strong buffer capacity of citric acid-Na2HPO4 buffer pair and the chelation action of citric acid and trace elements, the multi-trace-element injection (II) medicine composition prepared by the preparation method disclosed by the invention can still keep a stable pH degree when used together with other injections, thus preventing the trace elements from forming hydroxide precipitates due to the change of the pH after compatibility, preventing the mutual action of the trace elements and other medicines, greatly improving the safety of medication, and improving the compliance of patients to medicines.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a pharmaceutical composition of various trace element injections (II) and a preparation method thereof. Background technique [0002] The human body is composed of more than 50 elements, which can be divided into two categories: macro elements and trace elements according to the content of elements in the human body. Any element that accounts for more than one ten thousandth of the total weight of the human body, such as carbon, hydrogen, oxygen, nitrogen, phosphorus, sulfur, calcium, magnesium, sodium, etc., is called a constant element; any element that accounts for less than one ten thousandth of the total human body weight Elements such as iron, zinc, copper, manganese, chromium, selenium, molybdenum, cobalt, fluorine, etc., are called trace elements (iron is also called semi-trace elements). The content of trace elements in the human body is really neg...

Claims

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Application Information

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IPC IPC(8): A61K33/34A61K47/20A61K47/18A61K47/12A61K9/08A61P3/02A61K33/30A61K33/26A61K33/32A61K33/16A61K33/18
Inventor 胡友纯
Owner LIAONING HAISCO PHARMACEUTICAL CO LTD