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Identification method for diphenhydramine hydrochloride and procaine hydrochloride in musk blood circulation promoting and blood stasis removing ointment

A technology of diphenhydramine hydrochloride and procaine hydrochloride, which is applied in the directions of instruments, measuring devices, scientific instruments, etc., can solve extraction difficulties, low solubility of procaine hydrochloride, and unfavorable quality control of Musk Huoxue Huayu ointment and other problems to achieve the effect of strong specificity and good reproducibility

Inactive Publication Date: 2014-01-01
CHONGQING UNISPLENDOUR CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in the prior art, there is no report for the determination of procaine hydrochloride in the rubber plaster, and because procaine hydrochloride has little solubility in alcohol, it is difficult to propose it from the rubber plaster by adding alcohol to reflux, so the above-mentioned The method for determining the content of diphenhydramine hydrochloride in other rubber ointments is not applicable to procaine hydrochloride
As a rubber ointment, musk promoting blood circulation and removing blood stasis ointment is different from other preparations in that it contains a large amount of rubber matrix, which is composed of rubber, zinc oxide, rosin, lanolin, vaseline, liquid paraffin and other substances, and it is difficult to extract by the above methods Therefore, there is no report on qualitative or quantitative determination of diphenhydramine hydrochloride and procaine hydrochloride in Musk Huoxue Huayu Ointment in the prior art, which is not conducive to the quality control of Musk Huoxue Huayu Ointment

Method used

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  • Identification method for diphenhydramine hydrochloride and procaine hydrochloride in musk blood circulation promoting and blood stasis removing ointment
  • Identification method for diphenhydramine hydrochloride and procaine hydrochloride in musk blood circulation promoting and blood stasis removing ointment
  • Identification method for diphenhydramine hydrochloride and procaine hydrochloride in musk blood circulation promoting and blood stasis removing ointment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A kind of identification method of diphenhydramine hydrochloride and procaine hydrochloride in musk promoting blood circulation and removing blood stasis ointment, it is specifically measured according to the following steps:

[0038] (1) Preparation of the test solution

[0039] Take 10 tablets of Moskang Huoxuehuayu Ointment with batch number 20130603, remove the cover lining, cut into pieces, weigh 8g of it (equivalent to the amount of 4 of them), and use it as the test sample, add 50ml of ether, soak for 10 minutes, shake fully Shake to dissolve the ointment, add 15ml of water, shake fully, stand still, separate the water, wash with ether twice, 15ml each time, discard the ether, filter the water with dry filter paper, and take the filtrate to obtain the test product product solution;

[0040] (2) Preparation of reference solution

[0041] Precisely weigh the appropriate amount of procaine hydrochloride reference substance and diphenhydramine hydrochloride referen...

Embodiment 2

[0045] A method for identifying diphenhydramine hydrochloride and procaine hydrochloride in Moskva activating blood circulation and removing stasis ointment, which is to take 5 tablets of Moskva activating blood circulation and removing stasis ointment with batch number 20130701, remove the cover lining, cut into pieces, and weigh 8g of them ( Equivalent to wherein the amount of 4 pieces) as the test sample, according to the operation steps and methods in Example 1, prepare the test solution, the reference substance solution, and adopt high performance liquid chromatography to measure, finally obtain the present example For the chromatogram of the test solution, see the attached image 3 . Compare the chromatogram of the reference substance solution, that is, the attached figure 1 Known: the retention time of the chromatographic peak of procaine hydrochloride and diphenhydramine hydrochloride in need testing solution, is consistent with the retention time of the chromatograph...

Embodiment

[0047] A method for identifying diphenhydramine hydrochloride and procaine hydrochloride in Moskang activating blood circulation and removing blood stasis ointment, which is to take 5 pieces of Moskang activating blood circulation and removing stasis ointment with batch number 20130802, remove the cover lining, cut into pieces, and weigh 6g of them ( Equivalent to wherein the amount of 3 pieces), as the test sample, according to the operation steps and methods in Example 1, prepare the test solution, the reference substance solution, and adopt high performance liquid chromatography to measure, and finally obtain the For the chromatogram of the test solution, see the attached Figure 4 . Compare the chromatogram of the reference substance solution, that is, the attached figure 1 Known: the retention time of the chromatographic peak of procaine hydrochloride and diphenhydramine hydrochloride in need testing solution, is consistent with the retention time of the chromatographic ...

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Abstract

The invention relates to an identification method for diphenhydramine hydrochloride and procaine hydrochloride in a musk blood circulation promoting and blood stasis removing ointment. The method includes the following steps: firstly dissolving the ointment through diethyl ether; then adding water for dissolving; extracting the diphenhydramine hydrochloride and the procaine hydrochloride in the ointment; standing, skimming, washing the water solution through the diethyl ether, and filtering through a piece of dry filter paper; measuring a filtrate through the high performance liquid chromatography. The identification method is excellent in reproducibility, strong in specificity, avoids interference in negative control, can be used for one-time simultaneous qualitative identification for the diphenhydramine hydrochloride and the procaine hydrochloride in the musk blood circulation promoting and blood stasis removing ointment, and is applicable to quality control of the musk blood circulation promoting and blood stasis removing ointment.

Description

technical field [0001] The invention relates to the determination of diphenhydramine hydrochloride and procaine hydrochloride in Musk Huoxue Huayu Ointment, in particular to a method for identifying diphenhydramine hydrochloride and procaine hydrochloride in Musk Huoxue Huayu Ointment. Background technique [0002] Musk Huoxue Huayu Ointment is a compound rubber ointment preparation combining Chinese and Western medicine. It has obvious functions of promoting blood circulation and removing blood stasis, reducing inflammation and relieving pain. It is mainly used for the treatment of joint sprains, soft tissue contusions, acute lumbar sprains, lumbar muscle strain, and frozen shoulder. And diseases such as frostbite and erythema nodosum. The rubber plaster preparation contains eleven medicines, including not only notoginseng and other medicines with the effects of hemostasis, pain relief, blood stasis dispelling, and swelling reduction, but also diphenhydramine hydrochloride,...

Claims

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Application Information

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IPC IPC(8): G01N30/88
Inventor 罗延谷李文艳罗财勇何咏梅朱丽利
Owner CHONGQING UNISPLENDOUR CHEM
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