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Veterinary pefloxacin mesylate injection and preparation method thereof

A technology for pefloxacin mesylate and injection, which is applied in the field of veterinary pefloxacin mesylate injection and its preparation, can solve the problems of pH reduction, drug efficacy and drug safety effects, and achieves pH The effect of stable value, feasible preparation method and improved drug quality stability

Inactive Publication Date: 2014-01-08
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Observation and color comparison of the veterinary pefloxacin mesylate injection sample produced by the prior art showed that the pH value of the sample would be significantly reduced after sterilization and during storage, thereby reducing its efficacy. and drug safety have a certain impact

Method used

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  • Veterinary pefloxacin mesylate injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The veterinary pefloxacin mesylate injection provided in this example has the following ingredients: pefloxacin mesylate, 5g; disodium edetate, 0.05g; sodium bisulfite, 0.05g; citric acid-sodium citrate buffer solution, 30ml; add water for injection to 100ml.

[0023] Its preparation method comprises the following steps:

[0024] (1) Take an appropriate amount of water for injection, add the prepared amount of disodium edetate and stir to dissolve, add the prepared amount of sodium bisulfite and stir to dissolve, add the prepared amount of pefloxacin mesylate, stir and dissolve, and set aside;

[0025] (2) Prepare the prepared amount of citric acid-sodium citrate buffer, mix well, and set aside;

[0026] (3) Mix the two groups of solutions (1) and (2), add water for injection to the full amount, and adjust the pH value to 3.5-5.0;

[0027] (4) Filter the medicinal solution prepared in step (3) through a microporous membrane, potting, and sterilizing at 105°C for 30 mi...

Embodiment 2

[0029] The veterinary pefloxacin mesylate injection provided in this example has the following ingredients: pefloxacin mesylate, 5g; disodium edetate, 0.1g; sodium pyrosulfite, 0.1g ; Citric acid-sodium citrate buffer, 50ml; add water to 100ml for injection.

[0030] Its preparation method is with embodiment 1.

Embodiment 3

[0032] The veterinary pefloxacin mesylate injection provided in this example has the following ingredients: pefloxacin mesylate, 5 g; disodium edetate, 0.05 g; sodium metabisulfite, 0.05 g; Sodium bisulfite, 0.03g; citric acid-sodium citrate buffer, 30ml; add water to 100ml for injection.

[0033] Its preparation method is with embodiment 1.

[0034] The veterinary pefloxacin mesylate injection prepared in the above examples is the best embodiment of the present invention. Those skilled in the art can obtain the present invention by simply changing the combination ratio of relevant materials according to the formula provided by the present invention. The scope of the patent claims for protection is therefore not provided with an overly repetitive description of the embodiments.

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Abstract

The invention belongs to the technical field of preparation of veterinary drugs and in particular relates to a veterinary pefloxacin mesylate injection and a preparation method thereof. The veterinary pefloxacin mesylate injection comprises the following components of 1-10 percent (w / v) of pefloxacin mesylate, 0.05-1 percent (w / v) of complexing agent, 0.05-1 percent (w / v) of antioxidant, 1-50 percent (w / v) of pH buffer agent and the balance of thinning agent in the total 100 percent (w / v). Compared with the prepared injection in the prior art, the provided veterinary pefloxacin mesylate injection has the advantage that the drug quality is stable. Through long-term reserved sample observation and result comparison, the provided veterinary pefloxacin mesylate injection is stable in pH value and pharmaceutical effect, and the preparation method is feasible; therefore, the aim of the invention is well fulfilled.

Description

technical field [0001] The invention belongs to the technical field of preparation of veterinary drugs, in particular to a veterinary pefloxacin mesylate injection and a preparation method thereof. Background technique [0002] Pefloxacin mesylate is a broad-spectrum antibacterial agent with strong antibacterial activity among the third-generation quinolones. This product has strong tissue penetration and good absorption, and can effectively break through the blood-brain barrier. Cross-resistance, mainly used for infections caused by Gram-positive bacteria and Gram-negative bacteria and mycoplasma infections, and has a good inhibitory effect on Staphylococcus aureus, Escherichia coli, Salmonella, and Pseudomonas aeruginosa. [0003] At present, the commonly used dosage forms of pefloxacin mesylate are water-soluble powder and injection. The dosage form of the injection is light yellow clear liquid, which is prone to oxidative discoloration when exposed to light. Therefore, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/496A61P31/04
Inventor 张遂平邵艳华郭芳茹刘诗柱吴胜耀闫树森杨慧敏刘静
Owner 河南亚卫动物药业有限公司
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