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A kind of oxygen-carrying fluorocarbon emulsion and preparation method thereof

A technology of oxyfluorocarbon emulsion and emulsion, applied in the field of preparation of fluorocarbon emulsion

Inactive Publication Date: 2016-06-15
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few relevant reports about this method, and further research is still needed for its clinical application

Method used

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  • A kind of oxygen-carrying fluorocarbon emulsion and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: by weight, the formula is as follows:

[0015] Phosphate buffer solution (0.01M) 200 parts;

[0016] 100 parts of soybean lecithin;

[0017] FC-77200 copies;

[0018] 2 parts of tocopherol;

[0019] 1 part glycerin.

[0020] Preparation Process:

[0021] (1) In parts by weight, 100 parts of soybean lecithin, 2 parts of tocopherol, and 1 part of glycerin were dissolved in 2000 parts of saline solution, and stirred at 60°C for 2 hours until a uniform emulsion was formed.

[0022] (2) Cool the emulsion obtained in step (1) to room temperature, then add 200 parts of FC-77, and stir for about 30 minutes.

[0023] (3) Use a homogenizer to mix the mixed solution obtained in step (2) at a rate of 3000 rpm. The mixing is carried out intermittently. After stirring for 5 minutes, stop for 5 minutes and repeat for 5 hours. , That is, the oxygen-carrying fluorocarbon emulsion with soybean lecithin as a dispersant can be obtained.

Embodiment 2

[0024] Embodiment 2: by weight, the formula is as follows:

[0025] Phosphate buffer solution (0.01M) 200 parts;

[0026] 100 parts of egg yolk lecithin;

[0027] Perfluorooctyl bromide 200 parts;

[0028] 2 parts of tocopherol;

[0029] 1 part glycerin.

[0030] Preparation Process:

[0031] (1) In parts by weight, 100 parts of egg yolk lecithin, 2 parts of tocopherol, and 1 part of glycerin were dissolved in 2000 parts of saline solution, and stirred at 60°C for 2 hours until a uniform emulsion was formed. ,

[0032] (2) Cool the emulsion obtained in step (1) to room temperature, then add 200 parts of perfluorooctyl bromide and stir for about 30 minutes.

[0033] (3) Use a homogenizer to mix the mixed liquid obtained in step (2) at a rate of 3000 rpm. The mixing is carried out intermittently. After stirring for 5 minutes, stop for 5 minutes and repeat for 5 hours. , That is, the oxygen-carrying fluorocarbon emulsion with soybean lecithin as a dispersant can be obtaine...

Embodiment 3

[0034] Embodiment 3: by weight, the formula is as follows:

[0035] 200 parts of normal saline;

[0036] 150 parts of soybean lecithin;

[0037] FC-77300 copies;

[0038] 3 parts of tocopherol;

[0039] 2 parts glycerin.

[0040] Preparation Process:

[0041] (1) In parts by weight, 150 parts of soybean lecithin, 3 parts of tocopherol, and 2 parts of glycerin were dissolved in 2000 parts of normal saline, and stirred at 60°C for 2 hours until a uniform emulsion was formed.

[0042] (2) Cool the emulsion obtained in step (1) to room temperature, then add 300 parts of FC-77, and stir for about 30 minutes.

[0043] (3) Use a homogenizer to mix the mixed liquid obtained in step (2) at a rate of 3000 rpm. The mixing is carried out intermittently. After stirring for 5 minutes, stop for 5 minutes and repeat for 5 hours. , That is, the oxygen-carrying fluorocarbon emulsion with soybean lecithin as a dispersant can be obtained.

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Abstract

The invention relates to an oxygen-carrying fluorocarbon emulsion and a preparation method thereof. The specific steps of the method are as follows: firstly add phospholipids, tocopherol, and glycerin into the saline solution, stir at 60°C until a uniform emulsion is formed, then cool to room temperature, then add fluorocarbons, use a homogenizer, and The fluorocarbon oxygen-carrying emulsion with phospholipid as dispersant can be obtained by batch mixing for a certain period of time at a certain stirring rate. The fluorocarbon emulsion prepared by the invention has uniform particle size, small size and good dispersibility, and can be applied to emergency oxygen supply medicine, lung oxygen supply and the like.

Description

technical field [0001] The invention relates to a fluorocarbon emulsion formulation with a continuous water phase and a discontinuous fluorocarbon phase, and a preparation method of the fluorocarbon emulsion. Background technique [0002] Perfluorocarbons are a class of compounds obtained by replacing hydrogen atoms in hydrocarbons with fluorine atoms. They are generally colorless and transparent liquids at room temperature, with high density, stable properties, and are not prone to metabolic decomposition. They have the function of fully carrying oxygen and carbon dioxide. It is an ideal liquid breathing medium. Using the intrapulmonary route, it can provide treatment for acute respiratory distress, emergencies and other situations. [0003] At present, there have been reports on the use of fluorocarbons for direct oxygen supply to the lungs. Using direct liquid ventilation, that is, directly injecting oxygenated fluorocarbons into the lungs for gas exchange, although it ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/035A61K31/13A61K31/02A61K31/025A61K31/131A61K31/4375A61K31/47A61K31/40A61P11/00A61P7/06
Inventor 刘璐朱君何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH