Compound sulfamonomethoxine sodium injection as well as preparation method thereof

A technology of sodium methotrexate and compound sulfonamide, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of increased number of sick and disabled pigs, difficult to control, stagnation, etc. problems, to achieve the effect of expanding the antibacterial spectrum, less frequency of medication, and longer duration of action

Inactive Publication Date: 2014-02-05
南通海门凤成旅游文化发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex etiology of the disease, it is generally a mixed infection of multiple pathogens, it is difficult to control clinically, and the treatment effect is often unsatisfactory, resulting in slow or stagnant growth of pigs, an increase in sick pigs and dead pigs, feed efficiency, growth rate and pigs The overall uniformity of the herd is reduced, and the cost of treatment increases, causing severe losses in pig production
[0005] Most of the existing compound preparations of sulfamethoxine sodium are complex in composition, which is a simple superposition of various antibacterial and antiviral drugs. The safety of the drug needs to be further verified, and the long-term impact on livestock and drug residues need to be further studied

Method used

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  • Compound sulfamonomethoxine sodium injection as well as preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Prescription: sulfamethoxine sodium 1.5kg, potassium clavulanate 0.03kg, propylene glycol 3L, ethanol 1.5L, sodium thiosulfate 0.1kg, EDTA 0.001kg, water for injection to 10L.

[0038] Preparation:

[0039] 1) Mix and dissolve the prescribed amount of sulfamethoxine sodium and propylene glycol to obtain a propylene glycol solution of sulfamethoxine sodium;

[0040] 2) Mix and dissolve the prescribed amount of sodium thiosulfate and appropriate amount of water for injection to obtain sodium thiosulfate solution;

[0041] 3) Mix and dissolve the prescribed amount of potassium clavulanate with an appropriate amount of water for injection to obtain potassium clavulanate solution;

[0042] 4) Mix and dissolve the prescribed amount of EDTA and ethanol to obtain EDTA ethanol solution;

[0043] 5) Add the solutions prepared in step 2), step 3) and step 4) into the solution prepared in step 1) respectively under stirring, mix and stir well;

[0044] 6) Add 0.0...

Embodiment 2

[0048] Prescription: sulfamethoxine sodium 4kg, potassium clavulanate 0.3kg, propylene glycol 4L, ethanol 1L, sodium thiosulfate 0.1kg, EDTA 0.005kg, water for injection to 10L.

[0049] Preparation:

[0050] 1) Mix and dissolve the prescribed amount of sulfamethoxine sodium and propylene glycol to obtain a propylene glycol solution of sulfamethoxine sodium;

[0051] 2) Mix and dissolve the prescribed amount of sodium thiosulfate and appropriate amount of water for injection to obtain sodium thiosulfate solution;

[0052] 3) Mix and dissolve the prescribed amount of potassium clavulanate with an appropriate amount of water for injection to obtain potassium clavulanate solution;

[0053] 4) Mix and dissolve the prescribed amount of EDTA and ethanol to obtain EDTA ethanol solution;

[0054] 5) Add the solutions prepared in step 2), step 3) and step 4) into the solution prepared in step 1) respectively under stirring, mix and stir well;

[0055] 6) Add 0.5% (w / v) act...

Embodiment 3

[0059] Prescription: sulfamethoxine sodium 3kg, potassium clavulanate 0.1kg, propylene glycol 5L, ethanol 1.5L, sodium thiosulfate 0.2kg, EDTA 0.01kg, water for injection to 10L.

[0060] Preparation:

[0061] 1) Mix and dissolve the prescribed amount of sulfamethoxine sodium and propylene glycol to obtain a propylene glycol solution of sulfamethoxine sodium;

[0062] 2) Mix and dissolve the prescribed amount of sodium thiosulfate and appropriate amount of water for injection to obtain sodium thiosulfate solution;

[0063] 3) Mix and dissolve the prescribed amount of potassium clavulanate with an appropriate amount of water for injection to obtain potassium clavulanate solution;

[0064] 4) Mix and dissolve the prescribed amount of EDTA and ethanol to obtain EDTA ethanol solution;

[0065] 5) Add the solutions prepared in step 2), step 3) and step 4) into the solution prepared in step 1) respectively under stirring, mix and stir well;

[0066] 6) Add 0.1% (w / v) ...

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Abstract

The invention discloses a compound sulfamonomethoxine sodium injection, and relates to the field of preparation of veterinary medicines. The compound sulfamonomethoxine sodium injection is prepared from medicines and auxiliary materials such as sulfamonomethoxine sodium, propylene glycol, ethanol, an antioxidant, EDTA (Ethylene Diamine Tetraacetic Acid) and potassium clavulanate. The invention further provides a preparation method of the compound sulfamonomethoxine sodium injection. The compound sulfamonomethoxine sodium injection disclosed by the invention as a novel veterinary compound preparation can be effective by one injection for frequently occurred epidemic mixed influenza. The compound sulfamonomethoxine sodium injection disclosed by the invention has a unique curative effect to porcine contagious pleuropneumonia, cough and enzootic pneumoniae. The compound sulfamonomethoxine sodium injection is superior to a common medicine florfenicol in both curative effect and porcine weight increment.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to a compound sulfamethoxine sodium injection and a preparation method thereof. Background technique [0002] Sulfamonomethoxime Sodium (Sulfamonomethoxime Sodium) is a sulfonamide synthetic antibacterial drug, which is the sulfonamide drug with the strongest antibacterial effect in vivo and in vitro. It has a strong inhibitory effect on most Gram-positive bacteria and negative bacteria, and bacteria are slow to develop resistance to this drug. It is mainly used for various diseases caused by various sensitive bacteria, such as respiratory tract, digestive tract, and urinary tract infection. It has good curative effect on swine toxoplasmosis, swine edema, poultry and rabbit coccidiosis, and can be treated by local infusion. mastitis and endometritis etc. Its antibacterial mechanism is to inhibit the growth and reproduction of bacteria by inhibiting the synthesis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61K9/08A61K47/18A61P31/04A61P31/12A61P31/00A61P33/00A61P29/00A61P11/06A61P11/14A61P11/00A61K31/424
Inventor 刘学键
Owner 南通海门凤成旅游文化发展有限公司
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